Purpose: Based on a self-controlled case, this study evaluated the finite element analysis (FEA) results of a single missing molar with wide mesiodistal length (MDL) restored by a single or double implant-supported crown.

Methods: A case of a missing bilateral mandibular first molar with wide MDL was restored using a single or double implant-supported crown. The implant survival and peri-implant bone were compared. FEA was conducted in coordination with the case using eight models with different MDLs (12, 13, 14, and 15 mm). Von Mises stress was calculated in the FEA to evaluate the biomechanical responses of the implants under increasing vertical and lateral loading, including the stress values of the implant, abutment, screw, crown, and cortical bone.

Results: The restorations on the left and right sides supported by double implants have been used for 6 and 12 years, respectively, and so far have shown excellent osseointegration radiographically.

The von Mises stress calculated in the FEA showed that when the MDL was >14 mm, both the bone and prosthetic components bore more stress in the single implant-supported strategy. The strength was 188.62–201.37 MPa and 201.85–215.9 MPa when the MDL was 14 mm and 15 mm, respectively, which significantly exceeded the allowable yield stress (180 MPa).

Conclusions: Compared with the single implant-supported crown, the double implant-supported crown reduced peri-implant bone stress and produced a more appropriate stress transfer model at the implant-bone interface when the MDL of the single missing molar was ≥14 mm.

Purpose: The purpose of this study is to compare the shear bond strength of ultraviolet (UV)-polymerized resin to 3D-printed denture materials, both with and without post-polymerization. Moreover, the effects of surface treatment and thermocycling on shear bond strength after post-polymerization were investigated.

Methods: Cylindrical 3D-printed denture bases and teeth specimens were prepared. The specimens are subjected to two tests. For Test 1, the specimens were bonded without any surface treatment or thermal stress for comparison with and without post-polymerization. In Test 2, specimens underwent five surface treatments: untreated (CON), ethyl acetate (EA), airborne particle abrasion (APA) with 50 μm (50-APA) and 110 μm alumina (110-APA), and tribochemical silica coating (TSC). A UV-polymerized resin was used for bonding. Half of the Test 2 specimens were thermocycled for 10,000 cycles. Shear bond strength was measured and analyzed using Kruskal-Wallis and Steel-Dwass tests (n = 8).

Results: In Test 1, post-polymerization significantly reduced shear bond strength of both 3D-printed denture materials (P < 0.05). No notable difference was observed between the denture teeth and the bases (P > 0.05). In Test 2, before thermocycling, the CON and EA groups exhibited low bond strengths, while the 50-APA, 110-APA, and TSC groups exhibited higher bond strengths. Thermocycling did not reduce bond strength in the latter groups, but significantly reduced bond strength in the EA group (P < 0.001).

Conclusions: Post-polymerization can significantly reduce the shear bond strength of 3D-printed denture materials. Surface treatments, particularly APA and TSC, maintained bond strength even after thermocycling.

Purpose: Color-changeable chewing gums are used to evaluate masticatory performance, as measured by a colorimeter or visually based on a color scale. Although anyone can use a color scale, the evaluation accuracy depends on the evaluator. We develop an application that can determine the degree of color change in chewing gum using smartphone images, making color evaluation accurate and easy to measure.

Methods: For the application, 60 chewed gum samples were prepared. Two shots were captured using two smartphone models. To create the application algorithm, a formula was developed to approximately map the color value from the smartphone images to the true value using a colorimeter. A basic validation was performed on 60 new samples covering a range of colors, followed by a field validation on 100 healthy dentate participants aged 20–39 years.

Results: The intraclass correlation coefficient for two repeated shots had a high value ≥ 0.97 in the basic and field validations, confirming reliability. No significant differences were observed in the paired t-test and Wilcoxon signed-rank test, and a significant and strong correlation (correlation coefficient ≥ 0.92) was observed between the evaluation values using the colorimeter and the basic and field validations. Bland–Altman plots further confirmed the validity of the application.

Conclusions: A software application was developed to enable easy, quick, and accurate determination of the masticatory performance of a chewing gum from images taken using a smartphone with highly reliable and validated results.

Purpose: This study aimed to investigate whether the presence of a mesial cantilever influences the biomechanical behavior and screw loosening in fixed partial dentures (FPDs) with a distally tilted implant in the atrophic posterior maxilla and where to best place the distal implant.

Methods: Two configurations of implant-supported four-unit FPDs were modelled using finite element analysis. Five interabutment distances were considered. The stress and strain distributions in the implants, abutments, and prosthetic screws were verified under occlusal loading. The development of the axial force on the abutments and screws was also examined. Two-sample t-tests were used to identify differences (P < 0.05).

Results: The von Mises stress distributions of the components in the two configurations were similar, as were the maximum plastic strains of the distal prosthetic screws, distal implants, and 30° abutments. The difference in the maximum plastic strains of the straight abutments was statistically significant. The preload of the 30° abutment screws was significantly reduced after the initial loading. In the absence of a mesial cantilever, the axial force on the straight abutments increased. However, when a mesial cantilever was used, the preload of the straight abutments was maintained, and the axial force on the prosthetic screws fluctuated less. The axial force fluctuation of the abutments gradually decreased as the interabutment distance increased.

Conclusions: Mesial cantilever usage had minimal effect on stress or strain distribution in FPD implants, abutments, or prostheses. However, it helped resist screw loosening. The distal screw access hole was preferably positioned close to the prosthetic end.

Purpose To assess elution from direct composite materials for provisional restorations and compare them with elution from direct restorative composites for permanent restorations.

Methods Two dual-cure (Integrity Multi-Cure and Tempsmart DC) and two self-curing composites (Protemp 4 and Structur 3) were used, with Essentia serving as a reference. Cylindrical specimens (n=20) were cured according to the manufacturer's instructions; the dual-cure materials were prepared in both self- and dual-curing modes. Elution experiments were performed using water and absolute ethanol. The samples were incubated at 37 °C for either 24 h or four weeks; the extraction solvents were refreshed weekly. The eluted BisEMA (-3 / -6 / -10), BisGMA, CQ, UDMA, and TEGDMA were quantified using UHPLC-MS/MS.

Results Monomer elution was detected in all provisional composites at 24 h and four weeks, but the amounts released did not exceed those released by the reference composite. When prepared in self-curing mode, Integrity Multi-Cure exhibited significantly higher elution of BisEMA-3, -6, and -10 in ethanol both after 24 h and cumulatively after four weeks. Self-cured Tempsmart DC released significantly more CQ, TEGDMA, and UDMA in both water and ethanol after immersion for 24 h and four weeks, along with significantly more BisGMA in ethanol both after 24 h and four weeks comparison to dual-cured Tempsmart DC (two-way ANOVA, post-hoc Tukey, P < 0.05).

Conclusions Provisional composite materials did not elute higher amounts of monomers than a restorative composite. Dual-cured materials, prepared in the self-curing mode, show a trend towards higher monomer elution.

Purpose: To determine whether the number of functional teeth, including the remaining natural teeth and prosthetically restored missing teeth, is associated with the dietary inflammatory index (DII), a quantitative measure of the inflammatory potential of the overall diet, in middle-aged and older Japanese adults.

Methods: National survey data from a non-institutionalized Japanese population aged ≥45 years was analyzed. Multivariable linear regression analyses were performed to assess the association between the DII score, which was calculated based on dietary records, and the number of functional teeth, which was determined during dental examination. All regression analyses were stratified according to the age groups 45–64, 65–74, and ≥75 years. The association between functional tooth units (FTUs) and the DII was assessed using sensitivity analysis.

Results: In total, 2407 individuals (1053 men and 1354 women; mean age = 66.7 years) were included. Multivariable analysis revealed that the number of functional teeth was significantly inversely associated with the DII score among participants aged ≥75 years (regression coefficient per increase of one in the number of functional teeth = -0.050; 95% confidence interval = -0.089 to -0.010). The number of functional teeth was not associated with the DII score in younger age categories (i.e., those aged 45–74 years). As in the primary analysis, the number of FTUs was significantly inversely associated with the DII score only in the group aged ≥75 years.

Conclusions: A greater number of functional teeth was associated with a lower DII (i.e., diet with greater anti-inflammatory potential) in Japanese adults aged ≥75 years.

Purpose: This scoping review aimed to identify and discuss the recyclability of dental zirconia residuals along with the factors influencing the properties of dental recycled zirconia.

Study selection: In vitro studies written in both English and Chinese that evaluated the recyclability of dental zirconia residue were selected. A literature search was conducted in Medline, PubMed, Web of Science, and Cochrane Library databases with no restrictions on the publication year.

Results: Sixteen studies were included in this review. Residual dental zirconia can be recycled. Cold isostatic pressing improved the density of recycled zirconia compared with uniaxial pressing. Recycled zirconia powder with fine particles enhanced the performance of recycled zirconia compared with coarse particles. A presintering temperature of 950 to 1100°C was suitable for preparing recycled zirconia presintered bodies. Recycled zirconia may require a higher sintering temperature (≥1500°C) compared with commercially available zirconia. Additionally, recycled zirconia powder can enhance the properties of polymethylmethacrylate as a reinforcing filler and can be combined with alumina powder to obtain an alumina/zirconia composite material.

Conclusions: Despite a limited body of literature, the recycling and reutilization of dental zirconia residuals are feasible and reliable, and can reduce economic and environmental losses. Nevertheless, several factors influence the recycling effect, including the particle size, molding techniques, and sintering parameters. In addition, recycled zirconia powder can act as a reinforcing filler, potentially enhancing the mechanical properties of other materials. To realize commercially viable recycled zirconia materials, further studies are essential to comprehensively explore and understand their recycling performance.

Purpose: Depression is a leading cause of disability. Although tooth loss increases the risk of depressive symptoms, it is unclear whether dental prosthesis use moderates this risk. This study aimed to investigate whether dental prosthesis use moderates the association between tooth loss and new depressive symptoms in older adults.

Methods: This cohort study used data from the 2016 and 2019 Japan Gerontological Evaluation Study (JAGES). The participants were independent older adults aged ≥65 years without depressive symptoms in 2016. The onset of depressive symptoms in 2019 was the outcome variable. The explanatory variables were dental status (≥20 teeth, 10–19 teeth with or without dental prostheses, and 0–9 teeth with or without dental prostheses) in 2016. Risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using Poisson regression models with potential confounders as covariates.

Results: The analysis included 50,169 participants (mean age: 72.8 [standard deviation, 5.4] years). During follow-up, the incidence of depressive symptoms was 11.3%. Compared to those who had ≥20 teeth, the RR of depressive symptom onset was highest among those who had 0–9 teeth without dental prostheses (RR, 1.27; 95% CI, 1.04–1.56), after the adjustment for confounders. However, this risk was lower in those with 0–9 teeth and dental prostheses (RR, 1.08; 95% CI, 1.01–1.15).

Conclusions: These data highlight the potential of dental prostheses as an important factor in reducing the risk of depressive symptoms among individuals with severe tooth loss.

Purpose: This prospective cohort study examined the effects of the number of present and functional teeth on mortality among older Japanese adults requiring nursing care in an environment of comprehensive oral hygiene and nutritional management.

Methods: The study included 174 older adults (mean age: 84.4 ± 8.3 years; male/female: 49/125) in need of support or long-term care, who resided in either a local specialized healthcare facility or their own homes, and received daily oral hygiene and nutritional support at facilities in Okayama, Japan. The initial clinical oral examination along with assessment of general physical condition and nursing environment of the participants were performed in July 2013 and followed up for one year.

Results: All-cause mortality occurred in 28 (mean age: 88.7 ±13.4 years; male/female: 6 /22) individuals during the follow-up period. Cox proportional hazard analysis indicated that older age, low performance in activities of daily living (Barthel Index <40), and underweight status (body mass index <18.5) were significant risk factors for mortality. The number of present and functional teeth were not found to be significant risk factors for mortality.

Conclusions: During the one-year follow-up period, the number of present and functional teeth did not have a significant impact on mortality among older Japanese adults requiring nursing care in a well-managed environment of oral hygiene and nutritional status.

Patients: This case report presents a minimally invasive approach to replace a missing mandibular lateral incisor using a dual-injection molding technique with flowable composite resins. Integrated with a comprehensive digital workflow, this method achieves a structurally and esthetically biomimetic, bi-layered prosthetic solution. A 34-year-old woman with congenital absence of a mandibular lateral incisor was successfully rehabilitated using a direct composite resin-bonded fixed partial denture (RBFPD).

Discussion: Two specialized three-dimensional (3D)-printed flexible indices stabilized by a custom-designed 3D-printed rigid holder were employed to ensure the meticulous injection molding of flowable composite resins formulated to emulate the inherent chromatic gradations between dentin and enamel. The inherent flexibility of the indices, combined with the holder, facilitated accurate and seamless adaptation to the complex morphological features of the dental arch, thereby mitigating the challenges commonly associated with rigid 3D-printed resin indices.

Conclusions: The bilayered direct composite RBFPD using 3D printed flexible indices prepared with a full digital workflow has several advantages over other dental prosthetic solutions, including noninvasiveness, cost-effectiveness, biomimetic esthetics, repairability, and shortened treatment times. Although the initial results are promising, further longitudinal studies with larger patient cohorts are required to confirm the long-term efficacy of this approach.

Purpose: This in vitro study investigated the influence of material selection, crown morphology, and vertical crown height on the biomechanical behavior of monolithic hybrid abutment crowns (HACs).

Methods: Ninety implants were embedded in accordance with ISO standard 14801; ninety HACs were mounted (N=90). Monolithic crowns with varying group-specific designs were luted using titanium bases. HACs were fabricated from monolithic lithium disilicate ceramic (LD) or zirconia-reinforced lithium silicate ceramic (ZLS). The crown morphology was either maxillary premolar (LD_PM, ZLS_PM) or molar (LD_MO). The three groups were further divided into three subgroups of ten specimens, each designed with a small (7.5 mm), middle (10.5 mm), and high (13.5 mm) configuration of crown heights (N=10). A load-to-failure test at 30° off-axis was conducted using a universal testing machine until failure. For statistical analysis, Kolmogorov–Smirnov and Mann–Whitney U tests were conducted (P < 0.05).

Results: All LD_MO groups presented the highest failure values (808.7 to 947.9 N), followed by the LD_PM (525.8 to 722.8 N) and ZLS_PM groups (312.6 to 478.8N). A comparison between LD and ZLS materials (P < 0.001) as well as the crown morphology (P < 0.001) showed significant differences in failure values. The values in the subgroups of ZLS_PM (low, middle, high) decreased as the crown height increased. The fracture modes showed no consistent patterns across the test groups.

Conclusions: Material selection, crown morphology, and vertical crown height appear to be important factors that may influence the clinical failure values and patterns of HACs.

Purpose: This study aimed to investigate the effects of the age and sex of tooth donors on dentin bond strength.

Methods: A total of 38 extracted teeth (12 male and 26 female donors; age range: 17–82 years) were used in this study. In addition to donor age and sex, four other microtensile bond strength (μTBS) test specimen factors were evaluated: dentin position, bonding area, presence of voids at the interface, and computed tomography (CT) values of dentin. The μTBS was measured immediately (24 h) and 6 months after storage in water. After the μTBS testing, linear mixed and nonlinear regression models were used to analyze the effects of these factors on the μTBS data.

Results: The results from the linear mixed model revealed that the bonding area (P = 0.02), presence of voids at the interface (P = 0.04), and storage time (P < 0.001) significantly affected bond strength. In contrast, no correlation was observed between the μ TBS and dentin position (P = 0.08) or sex (P = 0.07). The results of the nonlinear regression model with robust variance–covariance estimators revealed that age significantly affected bond strength (P < 0.001). In addition, a significant positive correlation was found between μTBS and age (P < 0.001), with nonlinearity (P = 0.002). However, no correlation was observed between the μTBS and CT values (P = 0.69) without nonlinearity (P = 0.39).

Conclusions: These findings suggest that bond strength increases with age until 60 years but not afterward.

Purpose: The processes and methods of treating and polishing additive-manufactured (AMed) cobalt-chromium (Co–Cr) alloy clasps were assessed in vitro to determine their suitability for constant clinical use and the reduction of dental technician work.

Methods: AMed Aker clasps were fabricated by selective laser sintering of approximately 50 μm Co–Cr alloy powders. After the nodules and fins on the inner surface of the AMed clasps were removed and morphological correction was performed, a dental technician manually polished the clasps as a control. Four surface treatments, barrel finishing, shot peening, and wet and dry electropolishing, were performed to obtain smooth surfaces. In addition, hybrid manufacturing, which integrates repeated laser sintering and high-speed milling for one-process molding, was added to this study. After observing the treated surfaces using SEM and Hybrid Laser Microscope (HLM) the surface roughness, fitness accuracy, and retentive forces of the treated AMed clasps were measured, and their polishing efficiencies were compared.

Results: Similar to manual polishing, dry electropolishing yielded the smoothest surfaces in all treatments. The fitness accuracy of all clasp regions and treatment methods ranged from 80 to 140 μm, without significant differences among the treatment methods. All treated clasps showed acceptable retentive forces for clinical use, and hybrid manufacturing and wet electropolishing showed significantly higher forces.

Conclusions: AMed Co–Cr clasps with all surface treatments could be clinically used if additional slight manual polishing was performed; however, each processing condition should be carefully selected.

Purpose: This study aimed to determine the usefulness of machine learning techniques, specifically supervised and unsupervised learning, for assessing the cementation condition between a fixed partial denture (FPD) and its abutment using a resonance frequency analysis (RFA) system.

Methods: An in vitro mandibular model was used with a single crown and three-unit bridge made of a high-gold alloy. Two cementation conditions for the single crown and its abutment were set: cemented and uncemented. Four cementation conditions were set for the bridge and abutments: both crowns were firmly cemented, only the premolar crown was cemented, only the molar crown was cemented, and both crowns were uncemented. For RFA under cementation conditions, 16 impulsive forces were directly applied to the buccal side of the tested tooth at a frequency of 4 Hz using a Periotest device. Frequency responses were measured using a 3D accelerometer mounted on the occlusal surface of the tested tooth. Both supervised and unsupervised learning methods were used to analyze the datasets.

Results: Using supervised learning, the fully cemented condition had the highest feature importance scores at approximately 3000 Hz; the partially cemented condition had the highest scores between 1000 and 2000 Hz; and the highest scores for the uncemented condition were observed between 0 and 500 Hz. Using unsupervised learning, the uncemented and partially cemented conditions exhibited the highest anomaly scores.

Conclusions: Machine learning combined with RFA exhibits good potential to assess the cementation condition of an FPD and hence facilitate the early diagnosis of FPD retention loss.

Purpose: This systematic review examined the effectiveness of soft denture relining (SDR) materials.

Study selection: A comprehensive search of MEDLINE, Cochrane Library, and ICHUSHI was conducted up to July 26, 2020. Target outcomes were patient satisfaction, oral health-related quality of life (OHRQOL), masticatory ability (MA), denture functional duration, residual ridge resorption (RRR), and microbial contamination. An organization specializing in literature searches performed the reference searches, and two reviewers independently selected the literature sources, extracted the data, and assessed the risk of bias. The reviewers resolved any disagreements concerning the assortment of literature sources through discussion. SDR included acrylic- and silicone-based materials, which were evaluated separately.

Results: Reviewers selected 7, 5, 11, 1, 4, and 6 studies to assess patient satisfaction, OHRQOL, MA, functional duration, RRR, and microbial contamination, respectively. The results confirmed that SDR improved patient satisfaction, OHRQOL, MA, and RRR. However, the functional duration of SDR material is shorter than that of hard denture relining (HDR) or acrylic resin material. Furthermore, SDR material is more susceptible to microbial contamination in the long term. The risk of bias for the included studies tended to be high because of specific issues (difficulty in blinding SDR versus HDR).

Conclusions: For patients who wear complete dentures, SDR often provides beneficial outcomes such as pain reduction and recovery from MA. However, caution should be exercised regarding their use owing to insufficient functional duration and the possibility of microbial contamination during long-term use.

Purpose: This review aims to summarize the available technologies, material categories, and prosthodontic applications of additive manufacturing (AM) dental ceramics, evaluate the achievable accuracy and mechanical properties in comparison with current mainstream computer-aided design/computer-aided manufacturing (CAD/CAM) subtractive manufacturing (SM) methods, and discuss future prospects and directions.

Study selection: This paper is based on the latest reviews, state-of-the-art research, and existing ISO standards on AM technologies and prosthodontic applications of dental ceramics. PubMed, Web of Science, and ScienceDirect were amongst the sources searched for narrative reviews.

Results: Relatively few AM technologies are available and their applications are limited to crowns and fixed partial dentures. Although the accuracy and strength of AM dental ceramics are comparable to those of SM, they have the limitations of relatively inferior curved surface accuracy and low strength reliability. Furthermore, functionally graded additive manufacturing (FGAM), a potential direction for AM, enables the realization of biomimetic structures, such as natural teeth; however, specific studies are currently lacking.

Conclusions: AM dental ceramics are not sufficiently developed for large-scale clinical applications. However, with additional research, it may be possible for AM to replace SM as the mainstream manufacturing technology for ceramic restorations.

Purpose: To evaluate the effect of chemical, mechanical, and combination surface treatments on the shear bond strength (SBS) of autopolymerizing repair resins to conventional heat-cured, computer aided design (CAD)-computer aided manufacturing (CAM) milled, and three-dimensionally (3D) printed denture base materials.

Methods: Specimens were fabricated and divided according to the surface treatment as follows: no surface treatment (control group), monomer treatment (monomer group), resin remover treatment (resin remover group), roughening with 180 FEPA grit abrasive paper followed by monomer treatment (180-grit plus monomer group), and air particle abrasion (air abrasion group). Autopolymerizing resin cylinders were attached before accelerated aging of the specimens in water at 100 °C for 16 h. The SBS was tested using a universal testing machine. Surface roughness was evaluated using a 3D optical profilometer. Scanning electron microscopy (SEM) and stereomicroscopy were used for surface analysis. Data was collected and analyzed using analysis of variance (ANOVA) and Kruskall–Wallis tests (α = 0.05).

Results: The denture base material and surface treatment significantly affected the SBS. The milled Temp Basic Tissue demonstrated the highest SBS values across all surface treatments, whereas the two 3D-printed denture base materials exhibited the lowest SBS values.

Conclusions: The bond strength of CAD-CAM-milled denture base resins to autopolymerizing repair resins is comparable to that of heat-cured resins. Surface roughening using air particle abrasion or 180-grit carbide paper can enhance the bond strength of the autopolymerizing repair resin to 3D-printed denture base materials.

Purpose: Dental implant osseointegration comprises two types of bone formation—contact and distance osteogenesis—which result in bone formation originating from the implant surface or bone edges, respectively. The physicochemical properties of the implant surface regulate initial contact osteogenesis by directly tuning the osteoprogenitor cells in the peri-implant environment. However, whether these implant surface properties can regulate osteoprogenitor cells distant from the implant remains unclear. Innate immune cells, including neutrophils and macrophages, govern bone metabolism, suggesting their involvement in osseointegration and distance osteogenesis. This narrative review discusses the role of innate immunity in osseointegration and the effects of implant surface properties on distant osteogenesis, focusing on innate immune regulation.

Study selection: The role of innate immunity in bone formation and the effects of implant surface properties on innate immune function were reviewed based on clinical, animal, and in vitro studies.

Results: Neutrophils and macrophages are responsible for bone formation during osseointegration, via inflammatory mediators. The microroughness and hydrophilic status of titanium implants have the potential to alleviate this inflammatory response of neutrophils, and induce an anti-inflammatory response in macrophages, to tune both contact and distance osteogenesis through the activation of osteoblasts. Thus, the surface micro-roughness and hydrophilicity of implants can regulate the function of distant osteoprogenitor cells through innate immune cells.

Conclusions: Surface modification of implants aimed at regulating innate immunity may be useful in promoting further osteogenesis and overcoming the limitations encountered in severe situations, such as early loading protocol application.

Purpose: Some patients with mild-to-moderate obstructive sleep apnea (OSA) undergoing mandibular advancement device (MAD) therapy may exhibit residual sleep-breathing abnormalities. These cases require adjunctive treatment to further reduce the remaining airway inadequacy, which may affect the health and quality of life. This clinical trial was conducted since the oropharyngeal exercise, which aims to enhance the muscular function of the upper airway, combined with MAD, is unknown. We assessed the possible improvements in respiratory event parameters and lip and tongue physiological properties in patients with OSA who received oropharyngeal exercises for 2 months as an adjunct to MAD therapy.

Methods: Twenty-three participants with OSA who had been using MAD but still had residual apnea-hypopnea were randomly allocated to either the oropharyngeal exercise (OE group; N=12) or the sham exercise group (N=11). Lip and tongue strength, endurance, daytime sleepiness, respiratory event index (REI), and the lowest oxygen saturation (SpO₂ nadir) were determined.

Results: Within and between the treatment groups, no significant improvement in the REI or SpO₂ nadir was found. In both groups, there was a significant reduction in the Epworth Sleepiness Scale at 2 months (OE, P = 0.02; control, P = 0.02). In the OE group, lip endurance (P = 0.03), anterior tongue strength (P = 0.02), and endurance (P = 0.02) increased after 2-month of exercise, but only anterior tongue endurance increased significantly compared with the sham control (P = 0.01).

Conclusions: This study found that adjunctive OE to MAD showed no additive effect in treating patients with moderate OSA who had a mild residual apnea-hypopnea index following MAD treatment. However, the exercises successfully enhanced lip and anterior tongue endurance, as well as anterior tongue strength.

Patients: This case report describes a procedure for assessing changes in occlusal relationships in patients with acquired open bites due to temporomandibular joint disease using an intraoral scanner (IOS). A digital impression was made using the IOS at the initial visit. Subsequent impressions were made every 6 months using the IOS and magnetic resonance imaging (MRI) or computed tomography (CT). Standard triangulated language (STL) image files of two digital impressions at different points in time were superimposed, including the occlusal relationship with reference to the maxillary dentition. Finally, three-dimensional (3D) changes in the occlusal relationship over time were evaluated.

Discussion: In Case 1, the superimposed STL image indicated almost no evident deviation of the mandible. Therefore, an orthodontic treatment was initiated. In contrast, in cases 2 and 3, where changes in the occlusal relationship continued, secondary treatment was postponed and patients continued to be monitored periodically. In case 3, even though left condyle resorption was progressive, the degree of open bite on the right side improved after 6 months. However, the open bite continued to progress for another 6 months despite the stability of the condyle.

Conclusions: Changes in the condylar shape observed using imaging may not always reflect changes in the occlusal relationship. In addition to changes in the condyles and eminences of the temporomandibular joint (TMJ), changes in the occlusal relationships of patients with acquired open bite should be evaluated using an intraoral scanner.

Purpose: To investigate the effects of the number of ethylene oxide units in bis-EMA on the physical properties of additively manufactured occlusal splints.

Methods: Seven experimental materials containing bis-EMAs with three and 10 ethylene oxide units (BE3 and BE10, respectively) were prepared at different BE10 content rates (BE10-0%, -20%, -30%, -40%, -50%, -60%, and -80%). Half the specimens of each material were aged in boiling water. Flexural strength (FS), flexural modulus (FM), fracture toughness (FT), microwear depth (MD), degree of conversion (DC), water sorption (WSP), water solubility (WSL), color difference between non-aged and aged series (ΔE), and translucency (TP) were evaluated. All the evaluated properties other than FS and MD were analyzed by 1-way ANOVA and Tukey’s post hoc analysis, while FS and MD were analyzed by Kruskal–Wallis’s test and Bonferroni correction (α=0.05).

Results: BE10-80% revealed the lowest FS (P < 0.01 for BE10-0%, -20%, and -30%) and FM (P < 0.01, for all), while revealing the highest DC, WSP, WSL (P < 0.01 for all) and TP (P < 0.01 for all other than BE10-60%). BE10-50% showed the highest FT (P < 0.01 for all). BE10-50%, -60%, and -80% revealed significantly lower ΔE than others (P < 0.01) and lower MD than BE10-0% (P < 0.05). Regardless of the BE10 content, FS, FM, and FT decreased with aging.

Conclusions: The number of ethylene oxide units affects the physical properties of additively manufactured occlusal splints. The higher number of ethylene oxide units in bis-EMA enhanced the microwear resistance, DC, WSP, WSL, color stability, and translucency, whereas it deteriorated the FS and FM.

Purpose: This study aimed to elucidate the relationship between diurnal masseter muscle activity and awareness of diurnal awake bruxism (d-AB) by conducting a comparative analysis of electromyographic (EMG) data from individuals with and without awareness of diurnal awake bruxism (d-AB), utilizing EMG data gathered from multiple subjects.

Methods: Unilateral masseter electromyography (EMG) recordings were performed during the daytime using an ultraminiature wearable EMG device. A total of 119 participants (59 with awareness of diurnal tooth clenching [d-TC] and 60 without awareness of d-TC) were included. Waveforms longer than 0.25 s with the two amplitude conditions, exceeding twice the baseline and >5% of maximum voluntary clenching, were extracted. In addition, the number of bursts and episodes (groups of bursts), burst duration, and burst peak amplitude were calculated for each participant.

Results: There were no significant differences in the EMG parameters between the groups with and without awareness of d-TC. Additionally, the frequency distribution of the number of EMG waveforms exhibited wide ranges and substantial overlap between the two groups.

Conclusions: The variability in the number of bursts and episodes, burst peak amplitude, and burst duration among subjects suggests the need for an objective classification of d-AB severity based on EMG values. The absence of significant differences and large overlap in frequency distributions between the groups with and without awareness of d-TC indicate difficulty in predicting muscle activity solely based on awareness of d-AB.

Purpose: This study aimed to investigate the retentive force and deformation of double Akers’ polyetherketoneketone (PEKK) clasps on removable partial dentures (RPDs) with varying designs and undercut depths.

Methods: Thirty double Akers’ PEKK clasps with two different widths and heights (Groups I and II) were fabricated using computer-aided design and computer-aided manufacturing (CAD/CAM). Each design was further subdivided (n = 5) into three undercut depths (0.25, 0.50, and 0.75 mm). The retentive force of the clasps was measured after 10 years of clinical use (15,000 insertion/removal cycles), and the deformation of the clasp tips was analyzed before and after cycling.

Results: Clasps with 0.50-mm and 0.75-mm undercut depths exhibited greater initial retentive forces (3.15–3.51 N) compared to those in the 0.25-mm undercut group (2.40–2.80 N). Group I maintained consistent retentive forces over the cycles (P = 0.345), whereas Group II showed declining forces after the initial use (P < 0.003). In both groups, the 0.50-mm undercut exhibited a greater retentive force than the 0.25-mm (P < 0.001 and P < 0.004, respectively), with no significant differences between the 0.50-mm and 0.75-mm undercut depths. Despite a lower initial retentive force, the 0.25-mm undercut showed less deformation and clasp tip wear.

Conclusions: The PEKK clasps did not exhibit significantly reduced retentive forces or permanent deformations after 15,000 fatigue cycles. These results suggest that the PEKK polymer displays superior mechanical properties as an esthetic clasp material, and clasps with 0.50-mm and 0.75-mm undercut depths are recommended for long-term clinical use.

Purpose: This narrative review aimed to survey the clinical outcomes of laminate veneers (LVs), including their survival and success rates.

Study selection: An electronic search of MEDLINE/PubMed, Web of Science, Cochrane Library, and Google Scholar from 2000 to April 2023 was conducted using the keywords “laminate” OR “veneer” OR “porcelain” OR “feldspathic” OR “lithium disilicate” OR “composite resin” OR “zirconia” OR “survival” OR “success.” Case reports, case series, reviews, abstracts, in vitro studies, and observational studies were excluded. Five researchers independently evaluated the titles and abstracts of all identified studies.

Results: A total of 55 studies were identified. None of the studies met the criteria for zirconia LVs. According to the studies in this review, LVs fabricated with feldspathic porcelain, leucite-reinforced glass ceramics (LRG), and lithium disilicate ceramics (LDS) exhibited satisfactory survival and success rates. Furthermore, hydrofluoric acid etching followed by silane priming of the surface of ceramic LVs is necessary for improved clinical outcomes. The extent of dentin exposure significantly decreases the success rate of ceramic LVs. An appropriate adhesive luting process is required to achieve the long-term success of ceramic LVs. Dentin exposure should be minimized or sealed during tooth preparation to achieve a reliable and durable bond between LVs and abutment teeth.

Conclusions: Based on this narrative review of the literature, the use of silica-based ceramic feldspathic porcelain, LRG, and LDS is recommended for LVs.

Purpose: The aim of this study was to establish and assess the validity of in silico models of biaxial flexural strength (BFS) tests to reflect in vitro physical properties obtained from two commercially available computer-aided design/computer-aided manufacturing (CAD/CAM) ceramic blocks and one CAD/CAM resin composite block.

Methods: In vitro three-point bending and BFS tests were conducted for three CAD/CAM materials (n = 10): Katana Zirconia ST10 (raw material: super-translucent multilayered zirconia, ST10; Kuraray Noritake Dental, Niigata, Japan), Katana Zirconia HT10 (raw material: highly translucent multilayered zirconia, HT10; Kuraray Noritake Dental), and Katana Avencia N (AN; Kuraray Noritake Dental). Densities, flexural moduli, and fracture strains were obtained from the in vitro three-point bending test and used as an input for an in silico nonlinear finite element analysis. The maximum principal stress (MPS) distribution was obtained from an in silico BFS analysis.

Results: The elastic moduli of AN, HT10, and ST10 were 6.513, 40.039, and 32.600 GPa, respectively. The in silico fracture pattern of ST10 observed after the in silico evaluation was similar to the fracture pattern observed after the in vitro testing. The MPS was registered in the center of the tensile surface for all three specimens. The projections of the supporting balls were in the form of a triple asymmetry.

Conclusions: The in silico approach established in this study provided an acceptable reflection of in vitro physical properties, and will be useful to assess biaxial flexural properties of CAD/CAM materials without wastage of materials.

Purpose: To describe a novel digital design technique for creating an individualized emergence profile for implant restoration based on the contralateral tooth.

Methods: Cone beam computed tomography (CBCT) data were used to accurately obtain a three-dimensional (3D) model of the contralateral tooth, which was mirror-flipped to design the emergence profile. The emergence profile was further divided into critical and subcritical areas; the critical area precisely replicated the mirror-flipped 3D model, whereas the subcritical area featured a slight concavity on the buccal side, flatness on the lingual side, and slight convexity on the mesial and distal surfaces. Subsequently, a milling machine was used to fabricate healing abutments with individualized emergence profiles. The design of the definitive restoration completely duplicated the emergence profile of the individualized healing abutment and was fabricated using a milling machine.

Conclusions: This technical procedure presents an alternative novel method for designing the emergence profiles of implant restorations, with the potential to improve esthetics and functions as well as to maintain the long-term stability of peri-implant soft and hard tissues.

Purpose: To improve smile esthetics, clinicians should comprehensively analyze the face and ensure that the sizes selected for the maxillary anterior teeth are compatible with the available anthropological measurements. The inter commissural (ICW), interalar (IAW), intermedial-canthus (MCW), interlateral-canthus (LCW), and interpupillary (IPW) widths are used to determine the width of maxillary central incisors (CW). The aim of this study was to develop an automated approach using machine learning (ML) algorithms to predict central incisor width in a young Turkish population using anthropological measurements. This automation can contribute to digital dentistry and clinical decision-making.

Methods: In the initial phase of this cross-sectional study, several ML regression models—including multiple linear regression (MLR), multi-layer-perceptron (MLP), decision-tree (DT), and random forest (RF) models—were validated to confirm the central width prediction accuracy. Datasets containing only male and female measurements, as well as combined were considered for ML model implementation, and the performance of each model was evaluated for an unbiased population dataset.

Results: Compared with the other algorithms, the RF algorithm showed improved performance for all cases, with an accuracy of 96%, which represents the percentage of correct predictions. The plot reveals the applicability of the RF model in predicting the CW from anthropological measurements irrespective of the candidate’s sex.

Conclusions: These results demonstrated the possibility of predicting central incisor widths based on anthropometric measurements using ML models. The accurate central incisor width prediction from these trials also indicates the applicability of the proposed model to be deployed for enhanced clinical decision-making.

Purpose: To investigate whether depth-gauge burs in veneer preparations influence preparation depth in a randomized, controlled, single-blinded trial and whether inexperienced operators can perform adequate veneer preparations.

Methods: Participants were 20 undergraduate dental students with no prior veneer preparation experience. The instruments used were the “Laminate Veneer System” (LVS), “Keramik-Veneers. de” (KVD), and a “Freehand” group (FH) for reference. All participants prepared three educational acrylic resin maxillae and three mandibular central incisors mounted in typodonts in patient simulators. The objectives were to achieve a preparation depth of 0.6 mm (tooth 11) and 0.4 mm (tooth 31). The sequences of the instruments used and prepared teeth were randomized. The measurements were performed using a laser triangulation coordinate-measuring machine. The data were stratified according to tooth location.

Results: The preparation depths of both depth-gauge-instrument-groups LVS and KVD achieved the objectives significantly better than did the instruments from the “Freehand” group (P < 0.001). The differences between the depth gauge groups were insignificant, although the maximum preparation depths were smaller in the KVD group. Regarding the prepared teeth, the preparation depths in the mandibular incisors were lower, and the differences were smaller.

Conclusions: The use of special depth-gauge burs for initial veneer preparation leads to significantly lower preparation depths than “Freehand” preparations. The tapered instruments resulted in a lower incidence of extreme preparation depths. The inexperienced operators performed veneer preparation remarkably well.

Purpose: This study aimed to investigate the effect of collagen cross-link deficiency on collagen fiber formation around an implant and its effect on the osseointegration process.

Methods: Wistar rats were fed 0.1% beta-aminopropionitrile (BAPN) dissolved in water to induce collagen cross-link deficiency. Custom-made mini-implants with machined surfaces were placed proximal to the tibia. At 1, 2, and 4 weeks postoperatively, the bone area around the implant, bone-implant contact ratio, osteoclast/osteocyte activity, and osseointegration strength were evaluated using histological and immunohistochemical analyses and biomechanical tests.

Results: Long-term disturbance of collagen cross-link formation in the BAPN group resulted in faster collagen fiber maturation than that in controls, with a defective collagen structure, low bone formation quantity, and low bone-implant contact values. Deficiency of collagen cross-links resulted in increased bone resorption and decreased osteocyte activity.

Conclusions: Collagen cross-linking is important for the formation of the collagen matrix, and their deficiency may impair bone activity around implants, affecting the osseointegration process.

Purpose: Laughter is expected to have health-protective effects, but the potential link between tooth loss and laughter remains unclear. Therefore, this study aimed to examine the association between tooth loss and a low frequency of laughter among older adults in Japan, to elucidate whether this association could be mitigated by dental prostheses, and to evaluate the magnitude of the association mediated by poor oral function.

Methods: We used cross-sectional data from 157,708 functionally independent participants aged ≥65 years (46.3% male) from the Japan Gerontological Evaluation Study. A modified Poisson regression model was applied to examine the association between the number of remaining teeth (≥20/10–19/0–9), dental prostheses use, and infrequent laughter (i.e., laughing never or almost never). Causal mediation analysis was performed to assess whether the association was mediated by difficulties in eating hard foods, choking, or dry mouth.

Results: Among the participants, 9,129 reported infrequent laughter. Participants with ≤9 and 10–19 teeth who did not use dental prostheses had a 1.29 and 1.14 times higher likelihood of infrequent laughter than those with ≥20 teeth, respectively. Furthermore, difficulty eating hard foods, choking, and dry mouth mediated 22.8%, 0.4%, and 4.3% of the association between fewer remaining teeth and infrequent laughter, respectively. Meanwhile, we did not find evidence for the differences in infrequent laughter between participants with ≤19 teeth using dental prostheses and those with ≥20 teeth.

Conclusions: Tooth loss among individuals without dental prostheses was associated with infrequent laughter, and this association was mediated by poor oral function.

Purpose: In this narrative review, we present the current applications and performances of artificial intelligence (AI) models in different phases of the removable prosthodontic workflow and related research topics.

Study selection: A literature search was conducted using PubMed, Scopus, Web of Science, and Google Scholar databases between January 2010 and January 2023. Search terms related to AI were combined with terms related to removable prosthodontics. Articles reporting the structure and performance of the developed AI model were selected for this literature review.

Results: A total of 15 articles were relevant to the application of AI in removable prosthodontics, including maxillofacial prosthetics. These applications included the design of removable partial dentures, classification of partially edentulous arches, functional evaluation and outcome prediction in complete denture treatment, early prosthetic management of patients with cleft lip and palate, coloration of maxillofacial prostheses, and prediction of the material properties of denture teeth. Various AI models with reliable prediction accuracy have been developed using supervised learning.

Conclusions: The current applications of AI in removable prosthodontics exhibit significant potential for improving the prosthodontic workflow, with high accuracy levels reported in most of the reviewed studies. However, the focus has been predominantly on the diagnostic phase, with few studies addressing treatment planning and implementation. Because the number of AI-related studies in removable prosthodontics is limited, more models targeting different prosthodontic disciplines are required.

Purpose: To build an image recognition network to evaluate tongue coating status.

Methods: Two image recognition networks were built: one for tongue detection and another for tongue coating classification. Digital tongue photographs were used to develop both networks; images from 251 (178 women, 74.7±6.6 years) and 144 older adults (83 women, 73.8±7.3 years) who volunteered to participate were used for the tongue detection network and coating classification network, respectively. The learning objective of the tongue detection network is to extract a rectangular region that includes the tongue. You-Only-Look-Once (YOLO) v2 was used as the detection network, and transfer learning was performed using ResNet-50. The accuracy was evaluated by calculating the intersection over the union. For tongue coating classification, the rectangular area including the tongue was divided into a grid of 7×7. Five experienced panelists scored the tongue coating in each area using one of five grades, and the tongue coating index (TCI) was calculated. Transfer learning for tongue coating grades was performed using ResNet-18, and the TCI was calculated. Agreement between the panelists and network for the tongue coating grades in each area and TCI was evaluated using the kappa coefficient and intraclass correlation, respectively.

Results: The tongue detection network recognized the tongue with a high intersection over union (0.885±0.081). The tongue coating classification network showed high agreement with tongue coating grades and TCI, with a kappa coefficient of 0.826 and an intraclass correlation coefficient of 0.807, respectively.

Conclusions: Image recognition enables simple and detailed assessment of tongue coating status.

Purpose: Individuals with impaired masticatory function tend to prefer soft foods, which results in decreased masticatory muscle activity. This study examined the association between the oral condition (number of teeth, occlusal force, and occlusal contact area) and dietary hardness using a daily dietary questionnaire.

Methods: This cross-sectional study evaluated 1841 participants aged 69–71 and 79–81 years. Registered dentists examined the number of teeth, occlusal force, and occlusal contact area. Dietary hardness was defined as the estimated masticatory muscle activity required for a habitual diet. Habitual diet during the preceding month was assessed using a brief self-administered diet history questionnaire. Confounding factors, such as age, sex, socioeconomic status, smoking habits, history of chronic diseases (hypertension, hyperlipidemia, and diabetes), and cognitive function were also evaluated. Multivariate linear regression analyses were performed to assess the association between dietary hardness and each oral condition.

Results: Occlusal force (standardized regression coefficients [β]=0.08, P < 0.01) and occlusal contact area (β=0.06, P < 0.01) were significantly associated with dietary hardness after adjusting for the confounding factors. Number of teeth was not significantly associated with dietary hardness. In addition, the associations between dietary hardness, sex, and a history of diabetes were stronger than those between dietary hardness and oral factors.

Conclusions: Occlusal force and contact area were significantly associated with dietary hardness as estimated from the masticatory muscle activity using a daily diet questionnaire.

Purpose: A growing body of evidence suggests that oral health is associated with a wide range of health outcomes; however, opinions tend to vary because of inconsistent findings. This study aimed to simultaneously examine the association between oral health status and multiple health and well-being indicators using outcome-wide epidemiology.

Methods: Data were obtained from the Japan Gerontological Evaluation Study. Oral health status was categorized as: ≥20 teeth, 10-19 teeth with dental prosthesis, 0-9 teeth with prosthesis, 10-19 teeth without prosthesis, and 0-9 teeth without prosthesis. We examined the associations between oral health status in 2013 and 35 health and well-being outcomes in 2019, including physical/cognitive health, psychological distress, subjective health, social well-being, prosocial/altruistic behaviors, and health behaviors, using two databases (n=32,827 and 15,905).

Results: Compared to individuals with ≥20 teeth, those with <20 teeth had a 10-33% higher risk of mortality and a 7-10% higher risk of functional disability six years later. Additionally, individuals with fewer than 20 teeth tended to go out less frequently and eat fewer vegetables and fruits. Furthermore, individuals with 0-9 teeth without a prosthesis were more likely to have severe functional disability (risk ratio (RR):1.17, 95% confidence interval (CI):1.05-1.31), engage in fewer intellectual activities (standardized difference: 0.17, 95% CI: 0.10-0.24), and feel more hopeless (RR: 1.21, 95% CI: 1.04-1.41).

Conclusions: The prevention of tooth loss and prosthodontic treatment may be associated with reduced mortality and functional disability, as well as maintenance of intellectual ability, frequency of going out, and improvements in dietary lifestyle.