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Volume 3 (1972)
- Issue 4 Pages 281-
- Issue 3 Pages 179-
- Issue 2 Pages 89-
- Issue 1 Pages 1-
Volume 3, Issue 1
Displaying 1-11 of 11 articles from this issue
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[in Japanese]1972 Volume 3 Issue 1 Pages 1-2
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
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Yasushi Watanabe, Tadayuki Nagai, Yoshio Tanaka, Kiyoshi Motohashi, Yo ...1972 Volume 3 Issue 1 Pages 3-22
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSEnteric-coated tablets of aspirin-vitamin C, produced by nine Japanese makers, were examined in a disintegration test, for serum salicylate level after one oral administration and after repeated oral administration for six days.
The analgesic effects of the drugs and adverse reactions to the drugs were investigated in the patients and compared with the patients' salicylate levels.
As a result of these studies, which entailed administration of aspirin-vitamin C 6 T (as aspirin 1.5 g) three times a day, no significant difference could be found, between the analgesic effects of these drugs and the effect of a placebo. However, a clear difference between the drugs and the placebo was found in the adverse reactions to the drugs, at a level of significance of 5%.
As for serum salicylate levels during repeated oral administration for six days, it was observed that the serum salicylate level during administration of entericcoated tablets tended to be slightly lower than that during administration of the same quantity of aspirin powder. There was no relationship between the serum salicylate level and the patients' evaluation of analgesic effects or adverse reactions.View full abstractDownload PDF (2786K) -
Tomoji Yanagita, Saburo Takahashi, Kozaburo Esaki, Yoshikuni Tanioka, ...1972 Volume 3 Issue 1 Pages 23-30
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSIn the drug dependence liability studies, 4 tests were conducted. In the test on acute CNS effects of the drug, normal monkeys did not show any meaningful or physical changes with single oral doses of the drug at 50, 100, 200, 400, and 500 mg/kg.
In the test of substitution of Clonixin for morphine in morphine dependent and withdrawn monkeys, single oral doses of the drug at 20, 50, 100, and 200 mg/kg did not suppress morphine withdrawal signs, and thus did not support physical dependence on morphine.
In the physical dependence producing test on Clonixin, repeated oral administration of the drug to naive monkeys at daily doses of 100, 200, and 400 mg/kg for 4 weeks did not produce any physical dependence as observed by naloxone tests.
In the intragastric self-administration test in drug seeking behavior conditioned monkeys, Clonixin did not positively reinforce the drug seeking behavior. Thus, Clonixin was found to be dependence free.
In the teratogenicity test, 2 pregnant monkeys received 30 mg/kg, 2 other pregnant monkeys received 200 mg/kg, and one pregnant monkey received the vehicle alone, daily by gavage for 7 days, from the 23rd to 29th day of pregancy. All fetuses were removed from the uteruses by cesarean section on 59th, 60th or 61 st day of gestation. Detailed examinations of the fetuses revealed no abnormalities at all in external morphological appearance, visceral organs, or skeletal structures.View full abstractDownload PDF (1969K) -
Tomoji Yanagita, Saburo Takahashi1972 Volume 3 Issue 1 Pages 31-36
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSSedative-hypnotic type drug dependence liability of B 169, a new anticonvulsant, was studied in rhesus monkeys.
In gross behavior observation of acute CNS effects by single oral doses of 500 and 1000 mg/kg, no meaningful effect was observed. At 2000 mg/kg, a slight decrease of spontaneous motor activity and of awareness to outer stimuli was observed one hour after administration. The monkeys, however, reacted normally to man without any impairment of motor function.
In the cross physical dependence test in monkeys made, physically dependent on barbital and then withdrawn, the drug did not support the dependence when it was substituted for barbital at single oral doses of 1000 or 2000 mg/kg.
When drug seeking behavior conditioned monkeys were allowed to self-administer the drug intragastrically by pressing a lever switch in the cage without time or dose limitation, none of the animals voluntarily ingested the drug. Since they did not initiate self-administration, timer-programmed forced infusion of the drug into the stomach was conducted at a dose regimen of 20 mg/kg/infusion every 6 hours for 2 weeks. Initiation of self-administration was still not observed during or after the programmed administration period. No withdrawal signs were observed at the termination of programmed administration.
Thus, B169 was found to be dependence free.View full abstractDownload PDF (818K) -
[in Japanese]1972 Volume 3 Issue 1 Pages 37-44
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
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AKIRA SAKUMA1972 Volume 3 Issue 1 Pages 45-48
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 1 Pages 49-51
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 1 Pages 52-58
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
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1972 Volume 3 Issue 1 Pages 59-69
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 1 Pages 70-75
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
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[in Japanese]1972 Volume 3 Issue 1 Pages 76-84
Published: March 30, 1972
Released on J-STAGE: June 28, 2010
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