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Volume 8 (1977)
- Issue 4 Pages 421-
- Issue 3 Pages 265-
- Issue 2 Pages 137-
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Volume 8, Issue 2
Displaying 1-11 of 11 articles from this issue
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[in Japanese]1977 Volume 8 Issue 2 Pages 137-138
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
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Clinical Evaluation by a Double Blind Controlled Study with Desoximetasone, a Topical CorticosteroidExamination of Optimal ConcentrationYuzo TAKANASHI, Hideo YANAGIDA, Sadao YOSHIDA, Kido SUGITA1977 Volume 8 Issue 2 Pages 139-154
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSA double blind controlled study was conducted to compare the efficacy of 0.25% desoximetasone and 0.05% desoximetasone. 72 patients with the same skin lesion (acute eczema-like dermatitis or atopic dermatitis) on both sides of the body were selected for the study. One preparation was randomly chosen to be applied to the right side and the other was then applied to the left side two or three times a day. No occlusion was used. The data collected according to the degree of general improvement in each patient's skin condition, the posttreatment severity of his symptoms and the degree of utility was analyzed by the analysis of variance method. Data concerning relative effectiveness and relative utility was analyzed by Scheffë's paired comparison method.
For patients with acute eczema-like dermatitis, 0.25% desoximetasone proved to be statistically superior to 0.05% desoximetasone in such evaluation items as relative effectiveness, relative utility and posttreatment papule severity. With atopic dermatitis patients, no significant difference between the two concentrations was noted in any of the evaluation items.
Neither of the two concentrations produced any side effects. Both preparations proved to have an excellent therapeutic effect. 0.25% desoximetasone is considered to be more useful than the 0.05% concentration, however, particularly when the two preparations are used against the early stages of eczematous dermatitis.View full abstractDownload PDF (2393K) -
Keizo MATSUMOTO, Akira SAITO, Koichi YOKOYAMA, Tadashi KUSUNOKI, Yoshi ...1977 Volume 8 Issue 2 Pages 155-168
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSPatients with pneumonia have a variety of symptoms such as dyspnea, cyanosis, cough, rales, fever, chest pain, leukocytosis, increase of erythrocyte sedimentation rate, all of which do not appear, deteriorate or improve in a parallel manner. For making objective assessments in adequate and well controlled clinical investigations, it is favorable to use a rating scale which is well characterized both by the assessment criteria of the individual symptoms and by the investigation on the relationship between the various symptoms. Although some works on this subject have been done, the assessment method is not well established.
In this paper, data on 72 cases with bacterial pneumonia being applied, assess ment criteria for chest X-ray films is discussed, and factor analytic approach is adopted to examine the basic structure of symptoms including findings on X-ray films. Three factors were extracted, each of which was characterized by a corresponding group of symptoms such as cyanosis, rales etc. for the first factor, cough and sputum for the second, fever and other general symptoms for the third. It was turned out that the first followed by the second symptom group showed speedy recovery, whereas improvement of the third group was clearly delayed; the disappearance ratio after two-week treatment was 78.6%, 81.8%, 13.9% in the first, second and third symptom group respectively. Correlation of subjective global judgement with these characteristic inclinations of each symptom group observed here was also investigated, and finally, a tentative rating scale for the assessment of chemotherapy on pneumonia is proposed.View full abstractDownload PDF (7754K) -
Akira SAKUMA, Joji ISHIGAMI, Toshihiko MITA, Tadashi KUSUNOKI, Hirohis ...1977 Volume 8 Issue 2 Pages 169-181
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSIn clinical evaluations of chemotherapy, operational rating scales for clinical states or their changes have usually been employed to integrate and summarize several symptoms or signs.
This report describes an attempt to establish a rating scale for chemotherapy on simple acute cystitis. The data applied here were taken from a double blind study which was carried out lately to evaluate the efficacy of pivmecillinam including 216 cases with simple acute cystitis. For this study, subjective global judgement on the effect of chemotherapy was available together with data of four target symptoms: urinary frequency, pain during urination, WBC in sediment and bacterial count in urine.
Statistical analyses on interrelationship revealed considerable high correlation between global judgement and individual changes in symptoms, strongly suggesting that global judgement could be validly explained by these symptoms. Since changes in symptoms correlated with each other, one of them, pain during urination, could be dropped without loss of statistical efficiency. In adopting the remaining three symptoms, the squared multiple correlation coefficient R2 was 0.835, the correlaton ratio in Hayashi's quantification theory η2 was 0.880, and WBC had the largest weight in the estimation. As the result of these analyses, a simple scale of scores 0-8 was tentatively established, which agreed satisfactorily with global judgement; the agreement ratio was 87.7%.View full abstractDownload PDF (1551K) -
[in Japanese]1977 Volume 8 Issue 2 Pages 183-184
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
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William D' Aguanno1977 Volume 8 Issue 2 Pages 185-191
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
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FDA AND PMA COMMITTEES1977 Volume 8 Issue 2 Pages 193-201
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
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1977 Volume 8 Issue 2 Pages 203-218
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
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1977 Volume 8 Issue 2 Pages 219-234
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
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[in Japanese]1977 Volume 8 Issue 2 Pages 235-242
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
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[in Japanese], [in Japanese], [in Japanese]1977 Volume 8 Issue 2 Pages 243-247
Published: June 30, 1977
Released on J-STAGE: June 28, 2010
JOURNAL FREE ACCESSDownload PDF (899K)
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