Polymer-infiltrated ceramic network （PICN） materials consist of a dual-network structure of ceramic and resin skeletons. The mechanical properties of PICN materials are relatively close to those of human enamel and dentin in comparison with conventional ceramics or resin composites. PICN materials have attracted attention as tooth restorative materials due to their mechanical compatibility with human teeth. This review paper introduces contemporary PICN materials with mechanical, physicochemical, and bonding properties, biocompatibility, and its clinical applications. Further, advanced PICN materials reported in recent research are introduced and discussed regarding future perspectives.