Most patients following a sphincter-preserving operation (SPO) for middle and low rectal cancer develop defecatory dysfunction, including frequent bowel movements, fecal and gas incontinence, soiling, urgency, and so on;this is well known as low anterior resection syndrome (LARS).
LARS occurs in 80-90% of patients following an SPO for rectal cancer. Around 40% of patients following an SPO for rectal cancer have a major LARS. LARS is also persistent;in the literature, around 50% of patients following an SPO have had LARS for more than 10 years since they underwent the SPO for rectal cancer. Risk factors of a major LARS are reported to be radiation therapy, total mesorectal excision, anastomotic leakage, creation of a diverting stoma, and height of the anastomosis.
While SPOs are performed more frequently even for lower rectal cancer, multidisciplinary and multimodal treatments for LARS are required with dietary modifications, constipating agents, pelvic floor muscle training and biofeedback therapy, transanal irrigation, sacral neuromodulation, and creation of a permanent stoma.
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