In Japan, the initial risk assessment of chemical is carried out in two organizations. Although the result of these initial assessments is in agreement in general, chemicals in which results differ also exist. In the case of carbon disulfide, it became clear from comparison with the result of detailed risk assessment that the disagreement of two initial assessments originates in use of the human no observed adverse effect level derived from animal study and underestimate of exposure level accompanying use of monitoring data. Moreover, exposure around the handling facilities is not appropriately estimated in these initial assessments. Although these problems are improved in the method of the risk assessment under the Chemical Substances Control Law in Japan, it is necessary to verify and improve the method using the result of detailed risk assessment, if needed.
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