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Article type: Cover
1980 Volume 26 Pages
Cover1-
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Article type: Index
1980 Volume 26 Pages
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[in Japanese]
Article type: Article
1980 Volume 26 Pages
1-
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Tokio NEI
Article type: Article
1980 Volume 26 Pages
2-10
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Kazuhide YAMASATO
Article type: Article
1980 Volume 26 Pages
11-14
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Tetsuji SAWADA
Article type: Article
1980 Volume 26 Pages
15-16
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Yasuo ARIMOTO
Article type: Article
1980 Volume 26 Pages
17-
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Shinji YUASA
Article type: Article
1980 Volume 26 Pages
18-22
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Tokio NEI
Article type: Article
1980 Volume 26 Pages
23-27
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Takeo TANAKA
Article type: Article
1980 Volume 26 Pages
28-31
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Masakazu KOBAYASHI
Article type: Article
1980 Volume 26 Pages
32-36
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[in Japanese]
Article type: Article
1980 Volume 26 Pages
37-
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Shuji YAMAMOTO
Article type: Article
1980 Volume 26 Pages
38-45
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Eizo ASAHINA
Article type: Article
1980 Volume 26 Pages
46-51
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[in Japanese]
Article type: Article
1980 Volume 26 Pages
52-
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Hiroshi SOUZU
Article type: Article
1980 Volume 26 Pages
53-58
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Mitsuo TAKANO
Article type: Article
1980 Volume 26 Pages
59-63
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Seizo FUJIKAWA
Article type: Article
1980 Volume 26 Pages
64-69
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Yoshimi MAEDA, Shozo KOGA
Article type: Article
1980 Volume 26 Pages
70-73
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Toshiki MORICHI
Article type: Article
1980 Volume 26 Pages
74-76
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Masatoshi SUZUKI
Article type: Article
1980 Volume 26 Pages
77-80
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Article type: Appendix
1980 Volume 26 Pages
81-82
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Nobuyuki YAMASAKI
Article type: Article
1980 Volume 26 Pages
83-88
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Kageaki KOUNO, Toshihiko KUMAMOTO, Taiji INUI
Article type: Article
1980 Volume 26 Pages
89-95
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Takeshi SAKANE, Isao BANNO
Article type: Article
1980 Volume 26 Pages
96-100
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Kimihiro WATANABE, Junko WATANABE, Kazuteru YOKOSE, Sayuri ITOH, Mayum ...
Article type: Article
1980 Volume 26 Pages
101-109
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It is of supreme importance for better utilization of microbes in various fields to establish simple methods for maintaining not only the viability but also their biological activities for as long period as possible. Aiming eventually at obtaining a consolidated empirical rule for better preservation, the efficiency of various preservation methods was compared on the maintenance in productivity of such antibiotics as fumaramidmycin, pyrrothines, netropsin, actinomycins, etc., and in microbial resolution capability of Streptomyces strains with that of viability. Microbial resolution studied here includes the enantiospecific dehydrogenation of α-hydroxy acids and hydrolysis of Z-p-hydroxyphenylglycine. Results obtained confirmed a low correlation between viability loss and the decrease in the biological activities in general and a big difference among individual strains.
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Tokio NEI, Yoki MORI, Yasuyuki BABA
Article type: Article
1980 Volume 26 Pages
110-112
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Sunao KUBOTA, Tugunobu TAMURA, Yasuo IDEZUKI, Takashi YOKOI, Atsuhiro ...
Article type: Article
1980 Volume 26 Pages
113-117
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Tokio NEI
Article type: Article
1980 Volume 26 Pages
118-119
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Masakazu KOBAYASHI
Article type: Article
1980 Volume 26 Pages
120-128
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With extending use of pharmaceutical freeze dryers, the equipment have remarkably been improved lately. Unfortunately, in the opinion of some including both users and makers of the freeze dryer, the development of refrigeration system required for freeze dryers has not kept pace with advances in other component area. As compared with the conventional refrigeration system shown in Fig. 1-a, the system in Fig. 1-b which covers both vapor condenser load and shelf-cooling load with refrigerated brine circuation, ensures higher reliability on the temperature control, but is yet to be widely used because the system requires rather excessive refrigeration equipment in which energy consumption is comparatively bigger. Now, through the development of New Rifrigeration system indicated in Fig. 1-c, we have succeeded in combining the advantages of the aforesaid two systems, also eliminating their drawbacks. Features of our new system called "Triple Heat-Exchange Trap" system are that an array of plates in the vapor trap chamber serves as a heat exchanger with three effects; i.e. heat transfer between refrigerant and brine (1), between water vapor and refrigerant (2) and between water vapor and brine (3). With this new system, precise and easy control of the vapor trap is ensured without adoption of excessive refrigeration equipment and without excessive energy consumption.
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Masakazu KOBAYASHI, Konomi HARASHIMA
Article type: Article
1980 Volume 26 Pages
129-137
Published: August 31, 1980
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As we know of some consensus, including Rowe's "Eight Cliteria" (as guideline to the design and operation of static refrigerated condensers), on the vapor trap (or vapor condenser) of freeze dryers, there are, even today, different conceptions and advocations to this effect. With "Triple Heat-Exchange Trap" system which is introduced under the separate titile, we have observed ice build-up patters on the trap and deterioration of the trap capability through the progress of icebuilding on the trap. In comparing the observations with simplified mathematical model calulations, we have confirmed that both experimental and theoretical values are nearly equal. It was also confirmed that an increase of partial air pressure in the chamber has large bearings on the frontal ice building on the trap which deteriorates the trap capability rapidly.
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Yukiko MIZUNO, Naofumi HANAFUSA
Article type: Article
1980 Volume 26 Pages
138-140
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Masato SHIRAISHI, Kinji GONDA, Shozo KOGA
Article type: Article
1980 Volume 26 Pages
141-146
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Yoshimi MAEDA, Yoshio KAWAI, Kazuhide YAMASATO, Shozo KOGA
Article type: Article
1980 Volume 26 Pages
147-153
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Kiyosi HAYAKAWA, Mituhiro SATO
Article type: Article
1980 Volume 26 Pages
154-160
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The effect of formation of eutectic mixture between NaCl and H_2O on freezethaw damage of Saccharomyces cerevisiae which was suspended in NaCl was studied. When the suspension was frozen, survival ratio of the yeast decreased markedly after the temperature to form eutectic mixture. The maximal death occurred just before the completion of formation of eutectic mixture. Besides NaCl, KCl, succinic acid disodium salt and L-alanine also showed the same effect on the freeze-thaw damage of the yeast. On the other hand, formation of eutectic mixture did not damage Saccharomyces rouxii, a halo-tolerant yeast.
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Hiroshi SOUZU
Article type: Article
1980 Volume 26 Pages
161-163
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Toshichika OHTOMO, Kosaku YOSHIDA, C. L. SAN CLEMENTE
Article type: Article
1980 Volume 26 Pages
164-168
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Mitsuo TAKANO, Nozomi TANIHARA, Isao SHIBASAKI
Article type: Article
1980 Volume 26 Pages
169-175
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Logarithmic growing cells of Salmonella typhimurium, Pseudomonas aeruginosa, Klebsiella pneumoniae, Serratia marcescens, Escherichia coli and Micrococcus luteus were killed during a slow freezing to -30℃ with 1% ethanol, or some kinds of monohydric alcohol. The bactericidal effect was proportional to the logarithm of initial concentration of alcohol. The more lethal effect of freezing was observed with such alcohol having a higher straight and saturated arkyl chain less than 4 carbons. Addition of the alcohol soon after freeze-thawing was not lethal to bacteria. Glycerol decreased the bactericidal effect of freezing with alcohol. Concentrated solution of salts and alcohol which formed during freezing might be lethal to bacteria. The freeze-sterilization with alcohol might be applied to frozen foods containing protein or starch.
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Article type: Appendix
1980 Volume 26 Pages
176-177
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Article type: Bibliography
1980 Volume 26 Pages
178-196
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Article type: Appendix
1980 Volume 26 Pages
197-198
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Article type: Appendix
1980 Volume 26 Pages
199-201
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Article type: Appendix
1980 Volume 26 Pages
202-
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Article type: Appendix
1980 Volume 26 Pages
203-
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Article type: Appendix
1980 Volume 26 Pages
216-
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Article type: Appendix
1980 Volume 26 Pages
216-
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