The antibacterial activity of AB-206 was determined for a total of 790 strains of
Staphylococcus aureus, Haemophilus infiuenzae, Enterobacter, Proteus (Pr. vulgaris, Pr. mirabilis, Pr. morganii, Pr. rettgeri and
Pr. inconstans),
Serratia marcescens, Pseudomonas (
Ps. maltophilia, Ps. putida, Ps. fiuorescens and
Ps. cepacia),
Achromobacter xylosoxidans, Flavobacterium (
F. meningosepticum, F. sp.),
Acinetobacter calcoaceticus and
Alcaligenes faecalis isolated from various clinical materials at Clinical Laboratories of Juntendo University Hospital during the period from late 1976 to early 1977, and comparisons were made with that of NA, PA, PPA and other antibiotics in ordinary use.
1) AB-206 was equally active as ABPC against
H. influenzae.
2) When compared with GM, AB-206 was more active against flve species of
Proteus and
Serratia marcescens and almost equally active against
Enterobacter.
3) The antibacterial activity of AB-206 against four species of
Pseudomonas varied according to the species of the organisms, with rather strong activity against
Ps. cepacia and relatively weak activity against the other three species of organisms.
4) Against
Acinetobacter calcoaceticus, the antibacterial activity shown by AB-206 was inferior to that of MINO and DOTC and equal to that of GM.
5) Although the antibacterial activity of AB-206 against
Achromobacter xylosoxidans was weak, more than half strains of
Flavobacterium and
Alcaligenes had low MIC of AB-206.
6) When compared with NA, PA and PPA, AB-206 showed higher antibacterial activity against any of the strains tested in this study.
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