The principle of the hemodialysis depends on the phenomenons of both diffusion and ultrafiltration using the semipermeable membrane across the blood and dialysate. In these phenomenons, the small weight molecules of metabolites in the blood are easily removed, but the middle weight molecules of the uremic toxins can be little dialyzed in spite of long time dialysis.
In 1970, Chang et a l has developed the direct hemoperfusion using an albumin-coated, micro-encapsulated coconut activated charcoal on terminal stage of renal failure. The coconut charcoal, however, has a shape of irregular from and soft hardness. Therefore, fine particles freed from the charcoal becomes emboli in the lung.
We have deviced new type of an albumin-coated, micro-encapsulated, bead-shaped activated carbon made from petroleum. This activated charcoal has a spherical form leading micro-encapsulation easily and has strong hardnesss. So that we could not find any emboli in the lung of dogs. Also this charcoal has better absorbent capacity of creatinine and uric acid than coconut charcoal.
Although the charcoal absorbs no urea and water, hollow fiber kidney is applied to this system in series and simultaneous use for removing urea and water and for adjusting an acid-base balance.
Since August 1975, this new dialysis system has been applied on two patients treating with hemodialysis.
During three hours dialysis, reduction ratio of urea, creatinine and uric acid are 43.7, 59.2 and 68.9%. These show two to three times more absorbent capacity than cellulose membrane dialysis.
There is no effect of direct hemoperfusion to all kinds of blood cells; RBC decreased to be 1.25%, WBC decreased to be 8.84% (0.25>p.>0.1), platelets increased to be 1.7%.
These two patients have been kept well with good blood chemical data.
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