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  • 一般社団法人・日本老年歯科医学会
    老年歯科医学
    2022年 34 巻 supplement 号 1-21
    発行日: 2022/03/31
    公開日: 2022/06/03
    ジャーナル フリー
  • 梶原 稜, 山田 慎一, 西牧 史洋, 近藤 英司, 鎌田 孝広, 小山 力, 松岡 峻一郎, 竹田 哲, 三浦 健太郎, 山田 響子, 濱中 一敏, 伊藤 研一, 栗田 浩
    信州医学雑誌
    2018年 66 巻 4 号 249-256
    発行日: 2018/08/10
    公開日: 2018/09/20
    ジャーナル フリー
    Since lung cancer surgery has severe surgical invasiveness for patients, postoperative complications such as postoperative pneumonia are frequently seen. During cancer treatments, perioperative oral management (POM) is performed. However, there are few reports about the efficacy of POM on the prevention of postoperative pneumonia associated with lung cancer surgery. The aim of this study was to evaluate the efficacy of POM on the prevention of postoperative pneumonia after such surgery. Four hundred and eighty patients who recieved lung cancer surgery from January, 2013 to November, 2016 at Shinshu University Hospital were investigated in this study. The intervention rate of POM was 34.2% (164/480 patients). Postoperative pneumonia was seen in 23 patients (4.8%). The incidence of postoperative pneumonia was decreased significantly in the POM group compared to the non-POM group. In a multivariate analysis, performance status, surgical approach (thoracotomy vs video-assisted thoracic surgery), and POM were associated significantly with the onset of postoperative pneumonia. We conclude that the POM might help to prevent the occurrence of postoperative pneumonia after lung cancer surgery.
  • Hiroshi NAKAGAWA
    Journal of Oral Health and Biosciences
    2017年 30 巻 1 号 40-44
    発行日: 2017年
    公開日: 2017/06/30
    ジャーナル オープンアクセス
    Twenty years have passed since our division (clinic of the challenged) was organized in our institution. During this period, we have been engaged in dental care for patients with disability, contributing to this area of special needs dentistry in Tokushima Prefecture. Although the situation has consequently improved, the service remains insufficient to treat all such patients in the prefecture. This review discusses the current statuses of individuals with disabilities in and outside Japan and dental care for them in Tokushima Prefecture, with future perspectives on the latter.
  • 栗田 浩
    日本口腔外科学会雑誌
    2023年 69 巻 10 号 454-457
    発行日: 2023/10/20
    公開日: 2023/12/20
    ジャーナル フリー

    This paper outlines the revision process and contents of the revised ‟ Pathogenesis and Management of Drug-Related Osteonecrosis of the Jaw: Osteonecrosis of the Jaw Study Committee Position Paper 2023, ” especially concerning the prophylactic withdrawal of ARA for tooth extractions and the treatment and management of MRONJ.

     A systematic review was conducted on the prophylactic withdrawal of ARA at the time of tooth extraction. With the results, the position paper proposes that, ‟ in principle, ARA should not be withdrawn at the time of tooth extraction”. Regarding MRONJ treatment, surgical treatment has a higher cure rate than conservative treatment in stages 2 and 3, and surgical treatment is prioritized if the general condition allows. While, in stage 1, both conservative and surgical treatment are acceptable.

     We hope that you will read Position Paper 2023 carefully, disseminate its correct content, and reflect it in the health of the public.

  • 青田 桂子, 高野 栄之, 細川 浩良, 可児 耕一, 山村 佳子, 東 雅之
    日本口腔外科学会雑誌
    2013年 59 巻 7 号 478-482
    発行日: 2013/07/20
    公開日: 2014/12/09
    ジャーナル フリー
    We report a case of oral, pharyngeal, esophageal, and gastric ulcer in patient with Waldenström macroglobulinemia( WM) in a 64-year-old woman in whom remission was induced by the administration of rituximab 6 months previously. She consulted our hospital because of ulcer formation in the right side of the floor of the mouth. A biopsy specimen showed inflammation. Five days later, the patient had a fever of 39℃, and the ulcer extended to the tongue and the left side of the floor of the mouth. Blood examination demonstrated delayed-onset neutropenia after treatment with rituximab. Although the symptoms were improved by antibacterial therapy, the ulcer with fever recurred 4 months later. The ulcer was observed not only in the mouth, but also in the pharynx, esophagus, and stomach. Since neutropenia continued and CD19, a monoclonal B cell antibody, was 0% , the patient received both G-CSF and an antibacterial drug. In addition, a proton pump inhibitor was given. These treatments led to improvement of the ulcer.
    The fact that severe delayed-onset neutropenia was induced by rituximab in the patient suggested that infection with endogenous microbial flora caused the ulcer in the mouth, pharynx, esophagus, and stomach. On the other hand, in the stomach with few endogenous microbial flora, the lack of the regulatory B cells apparently inhibited IL-10 production. Consequently, the activation of macrophages and neutrophils may have caused the ulcer formation.
  • 茂木 勝美, 桃田 幸弘, 高野 栄之, 可児 耕一, 山村 佳子, 東 雅之
    日本口腔外科学会雑誌
    2013年 59 巻 12 号 786-790
    発行日: 2013/12/20
    公開日: 2014/12/22
    ジャーナル フリー
    Acquired hemophilia A is a rare disease. It is caused by the acquirement of factor VIII inhibitor. We report a case of acquired hemophilia A incidentally diagnosed on bleeding after tooth extraction. A 75-yearold woman referred to our hospital because of bleeding after tooth extraction. Hematological examination revealed a prolonged activated partial thromboplastin time (APTT) and decreased coagulation activity of factor VIII. In addition, a high level of factor VIII inhibitor was detected. Therefore, our patient was given a diagnosis of acquired hemophilia A. The patient was admitted to our hospital and received corticosteroids and bypass hemostasis using recombinant coagulation factor VII. On hospital day 42, APTT and factor VIII activity returned to the normal range. Moreover, factor VIII inhibitor disappeared. The patient was discharged and is being treated at a local general hospital.
  • 磯崎 淳
    感染症学雑誌
    2022年 96 巻 6 号 236-239
    発行日: 2022/11/20
    公開日: 2022/11/21
    ジャーナル フリー

    The patient was a 2-year 1-month-old boy who had undergone hypospadias repair 2 months earlier. He was brought to us with a 2-day history of fever and pain while urinating. A neighborhood doctor noted increased levels of inflammatory markers and the patient was referred to our hospital. He was admitted to our hospital and at admission, laboratory examination revealed elevated values of the peripheral blood leukocyte count (21,900/μL; neutrophils 82.5%) and serum C-reactive protein (CRP) level (13.0mg/dL). Urinalysis revealed pyuria, with a white blood cell count of 100 or more/high power field (HPF). Microscopic examination of the urine revealed phagocytozed Gram-positive rods in the white cells. The patient was diagnosed as having urinary tract infection and initiated on treatment with vancomycin. On the third day of hospitalization, the fever resolved, the inflammatory reaction decreased, and the pyuria improved. Vancomycin was administered for 10 days, and the patient was discharged on the 12th day of admission. Actinotignum schaalii was isolated and identified by culture of a urine specimen collected via a catheter at the time of admission. In recent years, there have been some reports in Japan of urinary tract infection caused by A. schaalii in children. When urinary tract infection is suspected, microscopic examination of Gram-stained specimens of the urine is important. If Gram-positive rods are observed under the microscope, it is necessary to consider the possibility of anaerobic bacteria and immediately carry out anaerobic culture. In addition, background diseases of the urinary system, such as urinary tract malformations, appear to predispose to urinary tract infections caused by A. schaalii, and further examination is needed.

  • -口内法枚数と口外法件数-
    吉原 穂積, 細木 秀彦, 吉田 みどり, 久米 芳生, 音見 暢一, 天野 雅史, 湯浅 将生, 山田 健二, 水頭 英樹, 前田 直樹, 川田 直伸, 原田 雅史, 誉田 栄一
    Journal of Oral Health and Biosciences
    2019年 32 巻 1 号 1-9
    発行日: 2019年
    公開日: 2019/07/03
    ジャーナル オープンアクセス
    After the computed radiography (CR) system was developed in 1986, it became possible to acquire, view and save digital images for medical diagnosis. Around that time, panoramic radiography was digitized by the CR system, but it was limited to large hospitals. From 1994, it has been digitized at large hospitals and dental clinics. We examined the changes in the number of intraoral and panoramic radiographs in dentistry, and based on the relationships among the numbers of radiographs, patients and dental operations, we discussed the clinical significance of digitization.
    We extracted intraoral and panoramic radiography data, the number of dental operations and the number of patients from the database of Tokushima University Hospital from 2002 to 2017. Then, we extracted nationwide data from Statistics of Medical Care Activities in Public Health by the Ministry of Health, Labour and Welfare from 2002 to 2017.
    As a result, although the numbers of patients and dental operations at Tokushima University Hospital have remained constant, the number of intraoral radiographs has decreased (72%), whereas the number of panoramic radiographs has increased annually since 2011 (131%). In addition, although the number of patients and nationwide insurance points increased in a different manner than that at Tokushima University Hospital, a decrease in the number of intraoral radiographs and an increase in the number of panoramic radiographs were noted across Japan. As panoramic imaging has been improved and adapted to different settings, panoramic radiography has been used instead of intraoral radiography, and it has been widely used in screening applications such as for perioperative patients. Although digitization is progressing, the analog images are still used (intraoral radiography analog rate, 29.7%, panoramic radiography analog rate, 12.4% in 2017).
  • 若林 類, 矢郷 香, 森川 暁, 中川 種昭, 朝波 惣一郎, 向井 萬起男
    日本口腔外科学会雑誌
    2008年 54 巻 9 号 550-554
    発行日: 2008/09/20
    公開日: 2011/04/22
    ジャーナル フリー
    Massive osteolysis is an extremely rare disease associated with aggressive resorption of bone. It is usually indolent and progresses rapidly. However, the etiology of this disease remains to be elucidated. We describe a 25-year-old woman who presented with massive osteolysis of the maxilla and mandible accompanied by severe pain and paralysis of the mental nerve. We performed a partial maxillectomy and a mandibular segmentectomy in March 2005. Approximately 3 years after the operation, the bone lysis of the jaws resolved and the associated pain disappeared. There has been no evidence of recurrence.
  • 金本 栄華, 小畑 協一, 竜門 省二, 岸本 晃治, 伊原木 聰一郎, 佐々木 朗
    日本口腔外科学会雑誌
    2023年 69 巻 1 号 15-21
    発行日: 2023/01/20
    公開日: 2023/03/20
    ジャーナル フリー

    Squamous cell carcinoma (SCC) is the most common malignancy in the head and neck region, while malignant lymphoma (ML) is relatively rare. According to reporting, synchronous double cancer of squamous cell carcinoma and malignant lymphoma in the head and neck is extremely rare.

     A 61-year-old man was referred to our department because of a tongue mass. The mass was elastic-hard and located on the right border of the tongue. Various imaging examinations revealed multiple lymphadenopathies throughout the body. Biopsy resulted in a diagnosis of synchronous double cancer of squamous cell carcinoma of the tongue and follicular lymphoma (FL). During a tumor clinical therapeutic conference, it was decided to prioritize tongue cancer treatment. Following preoperative chemotherapy, we performed a right-sided modified radical neck dissection, tongue cancer resection, and reconstruction using a pectoral major musculocutaneous flap. He was then given chemotherapy for the FL at the Department of Hematology and made good progress.

     Since the prognosis for synchronous double cancers is affected to a large degree by the order of treatment, it is very important to collaborate with the relevant specialized departments to provide multidisciplinary treatment.

  • —都道府県がん診療連携拠点病院 がん専門病院歯科の立場から—
    秦 浩信, 今待 賢治, 新山 宗, 林 信, 上田 倫弘
    日本口腔腫瘍学会誌
    2018年 30 巻 3 号 80-84
    発行日: 2018年
    公開日: 2018/09/24
    ジャーナル フリー
    独立行政法人国立病院機構に属する北海道がんセンターは北海道の都道府県がん診療連携拠点病院(以下 都道府県がん拠点病院)に指定されており全道各地よりがん患者が治療に訪れる。がん治療中の口腔内のトラブルに迅速かつ適切に対応することを目的として2012年に歯科口腔外科は開設され,2016年からは常勤体制となった。同年からは新たに口腔腫瘍外科も加わり,口腔癌診療を精力的に行っている。大学病院を除く都道府県がん拠点病院において,口腔がん治療と周術期口腔機能管理(がん支持療法)が分業できている施設は他になく,当院の特徴である。
    質の高い周術期口腔機能管理を実践するためには,病院内の他職種と連携が必須である。また,周術期口腔機能管理の継続性を担保するためには地域歯科医院との病診連携も重要になってくる。本稿では都道府県がん拠点病院の歯科としての役割をがん専門病院の立場から述べるとともに,当院で行っている医科歯科連携システムについて紹介する。
  • 新井 早苗, 合場 千佳子
    日本口腔保健学雑誌
    2020年 10 巻 1 号 73-80
    発行日: 2020年
    公開日: 2021/01/18
    ジャーナル フリー

     口腔がんは希少がんとして位置づけられるが,罹患率は増加傾向を示している.歯科衛生士は患者の口腔内を観察する専門職として,口腔がんに関する知識を習得することが重要であると考える.本研究は,歯科診療所に勤務する歯科衛生士を対象に,メインテナンス時の口腔内の観察部位や口腔がんの観察に対する意識を調査することを目的とした.関東近郊の歯科診療所に勤務する就業年数1年目から10年以上の歯科衛生士191名を対象に,無記名による自己記入式質問紙調査票を郵送し調査した.

     調査結果から,口腔がんに関する授業や講習会を受講している者は66.0%であるが,就業年数が経過していくにつれ受講している者は少なかった.口腔内を観察する部位では,歯肉が96.9%,口腔底が25.7%であった.口腔内写真を撮影している者は,75.0%であった.口腔がんを早期発見するためには,スタッフ間の情報共有が必要であり,口腔内写真は有効なツールと考える.口腔がんに関する部位別の意識調査においては,「意識している」として捉えている者の割合が8割以上と高い傾向を示した.しかし,口腔底については「たまに意識する」の割合が最も多く,定期的な観察意識は低い値となった.

  • 山村 佳子, 梅田 正博, 福田 全孝, 真砂 洋, 渋谷 恭之, 古森 孝英
    日本口腔外科学会雑誌
    2003年 49 巻 1 号 27-30
    発行日: 2003/01/20
    公開日: 2011/04/22
    ジャーナル フリー
    Massive osteolysis is a rare disease characterized by continuous and progressive resorption of bone. We present a case of massive osteolysis of the mandible that responded to radiation therapy.
    A 47-year-old man was referred to our hospital because of progressive resorption of the mandible. On the basis of clinical and histological findings, he was given a diagnosis of massive osteolysis. He underwent radiotherapy with 40 Gy, and no bone resorption has occurred for 1 year 5 months after treatment.
  • ―セファランチンの有効性に関する臨床病理学的研究―
    青田 桂子, 山村 佳子, 可児 耕一, 高野 栄之, 茂木 勝美, 桃田 幸弘, 石丸 直澄, 東 雅之
    日本口腔科学会雑誌
    2013年 62 巻 4 号 254-261
    発行日: 2013年
    公開日: 2013/10/10
    ジャーナル 認証あり
    Sjögren's syndrome (SS) is characterized by the eventual total replacement of the acinar structure by marked infiltration of lymphocytes into the salivary and lacrimal glands. We previously demonstrated that tumor necrosis factor-α (TNF-α) induced matrix metalloproteinase-9 (MMP-9) production by the stimulating transcription factor, nuclear factor-κB (NF-κB), in human salivary gland acinar cells and that cepharanthin, a biscoclaurine alkaloid, prevented the activation of TNF-α-induced NF-κB activity. In addition, we have shown that cepharanthin prevented the destruction of acinar tissues in murine SS. Thus, in this study, we investigated the clinicopathological effect of cepharanthin on the patients with SS.
    Ten patients with a diagnosis of primary SS were enrolled in this study. They were treated with cepharanthin for three months, followed by the evaluation of salivary production, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-SS-A antibody, anti-SS-B antibody, pathological examination of labial salivary gland biopsy specimens, and the symptom of drymouth.
    Average salivary production was 4.25ml/10minutes before the study. This average production increased to 6.46ml/10minutes after the study. There were no remarkable changes in CRP, ESR, anti-SS-A antibody and anti-SS-B antibody. In pathological findings, although the decreases in infiltration of lymphocytes were observed in 5 out of 5 cases, the reduction of destruction of acinar structures was clearly detected in 5 cases. Improvement of symptom of drymouth was detected in 7 out of 10 cases.
    These observations suggest that cepharanthin treatment might provide an efficient and useful therapeutic approach for countering the destruction of acinar tissue in salivary glands of patients with SS.
  • 大森 智栄, 小島 美樹, 永井 るみこ, 森崎 市治郎
    口腔衛生学会雑誌
    2022年 72 巻 1 号 18-27
    発行日: 2022年
    公開日: 2022/02/15
    ジャーナル フリー

     周術期口腔機能管理が保険収載され8年ほど経過し,実施現状の調査を目的とした,各病院対象の質問票調査を用いた報告がなされてきた.本研究では,病院に勤務する歯科衛生士の周術期口腔機能管理に対する意識を調査し,それに関連する要因を検討することを目的とした.記名を任意とした自記式質問票を作成し,2018年1月から2019年9月の期間で,30施設を対象に郵送法にて実施した.調査項目は,勤務先および勤務形態,周術期口腔機能管理の実施体制,歯科衛生士の意識,患者数とした.

     自記式質問票に対する回答を得た施設は30施設のうち27施設(回収率:90.0%)であり,歯科衛生士116名の有効回答を得た.周術期口腔機能管理に従事する歯科衛生士の不足を感じる者の割合は,病院種類や独立部署の有無,患者数を問わず,高い結果となった(70.7%).主成分分析により,抽出された3成分のスコアプロットをもとに,歯科衛生士数の不足感を検討したところ,不足感のある者は勤務施設における周術期口腔機能管理業務と他業務との兼任歯科衛生士数が多く,周術期口腔機能管理の活動度が低く,実施上の問題点が少ない傾向にあった.

     本研究結果から,周術期口腔機能管理に携わる歯科衛生士は,歯科衛生士数の不足を感じていた.そして,歯科衛生士数の不足感に影響する因子は単独ではなく,歯科における内的要因のみならず,医科や病院,地域歯科医院といった周術期口腔機能管理実施体制および環境等の外的要因を含む多因子であることが示唆された.

  • 丸岡 靖史, 佐藤 あや子, 山口 麻子, 田下 雄一, 高橋 浩二, 須田 玲子
    昭和学士会雑誌
    2020年 80 巻 5 号 382-389
    発行日: 2020年
    公開日: 2020/12/25
    ジャーナル フリー
  • 瀬田 拓, 飯島 進乃, 原 毅
    The Japanese Journal of Rehabilitation Medicine
    2022年 59 巻 7 号 674-680
    発行日: 2022/07/18
    公開日: 2022/09/05
    ジャーナル フリー

    開胸手術周術期に対するリハビリテーション医療の最終目標は,退院後生活のQOL向上である.術前治療は,オリエンテーション,術前評価,術前指導で構成され,術前の患者教育とコンディショニングによって術後早期離床を実現させることで,術後合併症を予防することを狙う.最近では,多職種による多面的サポートである術前外来の中で行われることが増えた.術前に限った治療の有効性については,データの蓄積がまだ不十分なのが現状である.エビデンスの蓄積,術後合併症予防,退院後生活における活動やQOL向上にも貢献できる術前リハビリテーション治療プログラムの開発が課題である.

  • 森田 奈那, 潮田 高志, 杉浦 慧, 秀島 能, 野村 武史, 松浦 信幸, 片倉 朗
    日本口腔診断学会雑誌
    2024年 37 巻 1 号 25-33
    発行日: 2024年
    公開日: 2024/04/10
    ジャーナル 認証あり
    Malignant lymphomas can be challenging to diagnose due to their diverse clinical manifestations. Although rare, they can develop as extranodal lymphomas in the oral cavity. Here, we report the case of a 79-year-old woman who presented to our hospital with right-sided maxillary palatal swelling. Initial examination revealed a soft, elastic lesion that appeared hyperintense on T2-weighted magnetic resonance imaging. Biopsy suggested follicular lymphoma. She consulted a hematologist, but no definitive diagnosis of follicular lymphoma was obtained. The lesion was low-risk according to the Follicular Lymphoma International Prognostic Index and did not meet the Groupe d’Etude des Lymphomes Folliculaires criteria, so we decided to follow her up. Subsequently, a tumor was discovered on the floor of her mouth. Biopsies from both lesions led to a definitive diagnosis of follicular lymphoma. Non-Hodgkin’s lymphomas such as follicular lymphoma can present as localized, diffuse soft tissue swelling and are often asymptomatic. The diagnosis of non-Hodgkin’s lymphoma can be challenging due to its wide range of clinical presentations.
    There are few reports of follicular lymphoma occurring with multiple oral lesions, but there are reports of progression to intermediate-grade lymphoma, suggesting the need for ongoing examinations and active surveillance in such cases.
  • 山近 重生
    歯科薬物療法
    2017年 36 巻 1 号 33-36
    発行日: 2017年
    公開日: 2017/04/20
    ジャーナル フリー
  • 在家 美幸, 山村 佳子, 濵田 佳子, 浅野 ゆう子, 岩間 朋子, 土肥 眞奈, 叶谷 由佳
    日本運動器看護学会誌
    2018年 13 巻 47-
    発行日: 2018年
    公開日: 2020/05/14
    ジャーナル オープンアクセス
    本研究は,人工股関節全置換術を受けた患者が術前後の車椅子乗車時に車椅子用マットを使用すること で,臀部圧力の軽減,疼痛の軽減,座り心地の改善が図れるかを主観的,客観的に検討することを目的とし た.19人の患者を対象に術前と術後4日目に2種類のマット(①TEMPUR―MEDケアクッション:以下 Tempur®とする,②エチレン―酢酸ビニル共重合樹脂発泡体マット:Ethylene-Vinyl-Acetate,以下EVAと する)を使用し,マットなしを含めた3群で,座位時の臀部にかかる圧力と疼痛,座り心地を調査し比較した. 術前後ともに臀部の除圧効果が最も高く,また座り心地が最も良い結果となったのはTempur®であった.疼 痛については有意差が認められなかったが,Tempur®が最も良い数値を示した.そのため臀部にかかる圧力 の軽減が座り心地の改善につながることが示唆された.
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