1. Minimum inhibitory concentration of Sisomicin was determined on 111 strains isolated from urinary tract infections by plate dilution method.
In 10
8 inoculum density, all strains of
E. coli were inhibited at 6.25 μg/ml or less and most strains of
Pseudomonas aeruginosa at 12.5 μg/ml or less. Eleven out of 19 strains of
Serratia were resistant to 100 μg/ml of Sisomicin. Antibacterial activity of Sisomicin against clinical isolates is equal to or stronger than that of Gentamicin.
2. In one patient with normal renal function, a peak blood level of 12.0 μg/ml was obtained one hour after intramuscular administration of 50 mg. Urinary recovery rate was 81.8% within 6 hours.
3. Twenty cases with complicated urinary tract infections were treated with 100 mg/day. “Excellent” and “good” results were achieved in 8 out of 19 patients. One patient did not complete trial.
4. Slight elevations of GOT and GPT in 2 and of Al. P-ase in 1 patient were observed.
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