統計的にみて,高血圧患者においては,他の疾患及び健常者に比し,夜尿回数の多い患者が多くみられることを知つた.そこで夜尿回数及び夜尿量を量り,更に夜尿率(夜尿量の一昼夜尿量に対する比)を算出し,これらと血圧,眼底所見及び腎機能との比較検討を行なつた。高血圧患者において,夜尿回数が3回以上ある場合は,夜尿量は700ccをこえるものが多く,夜尿率は50%以上あることをみた.夜尿率と血圧及び眼底所見,並びに腎機能すなわち或る種の腎機能検査成績との間に,おのおのかなり有意の相関関係のあることを知り,夜尿回数及び夜尿量をみることが臨床的に高血圧患者の病態,予後を知る上にかなり有意の指針となると考えられた.

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当地域は秋落ちが激しく, 昭和61年に「土づくり実践モデル地区設置事業」が導入された。この一環として。土壌肥料的諸要因と収量との関係を検討し, あわせて実効のある改善方針を策定するために当課題にとりくんだ。

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Various atherosclerosis risk factors have been presented for the past years on the basis of many clinical or epidemiologic studies. However, adequate clinical evaluation of atherosclerotic cardiovascular patients is impossible not infrequently. The purpose of this study is to make a statistical analysis on major clinical findings and laboratory data which are considered to cause or accelerate atherosclerotic cardiovascular lesion.
As a result, it was revealed that contribution of blood pressure to the formation and/or progress of atherosclerosis seemed more significant than other etiologic factorss we have studied in this report. Clinical findings of atherosclerosis related less closely with lipoprotein and lipid abnormalities than with blood pressure. However, we beleve more sophisticated qualitative and quantitative analyses of lipoproteins and lipids will reveal their actual state of contributions to the formation and/or progress of atherosclerosis.

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With the development of a practical method of polyacrylamide gel (PAG) electrophoresis of serum lipoproteins, sophisticated studies on serum lipid or lipoprotein disorders in atherosclerotic cardiovascular patients became possible. Qualitative and quantitative disorders of serum lipoproteins are estimated adequately even in modest to moderate hyperlipidemias which are quite prevalent among atherosclerotic cardiovascular patients. The objective of this presentation is to relate electrophoretic profiles of serum lipoproteins worked out with PAG disc method on an approximately 1815 clinical subjects.
Serum lipoprotein PAG disc electrophoretic profiles could be classified as six basic lipoprotein patterns. Four of six basic patterns seemed being consistent with the patterns of four of the established cases with familia hyperlipoproteinemia of WHO and other classifications, though none of our subjects had any clinical evidence of familial disorders. Presence of the midband lipoproteins and chylomicrons were major sources of a considerable number of the variations of the six basic patterns.
Occurrence of dense and wide midband was relatively rare in hyperpre-bata lipoproteinemia. In this abnormality, fluctuation of serum triglyceride concentration is evidently ascribable to chylomicrons which is clearly separated from pre-beta or beta lipoproteins with PAG method. The mixed hyperlipoproteinemia (referred to as the sixth phenotype by some) is detectable and identifiable with the method. Lipid chemistry of this abnormality was frequently indif f erentiable from those of other hyperlipoproteinemias. Dense and wide midband was detected frequently among hyperbeta lipoproteinemia with or without. moderately detectable pre-beta lipoprotein, though occurrence of the midband per se was not differred from the others. The midband showed considerable variations in electrophoretic characters. Hypercholesterolemia was common in these subjects, but triglyceride level was variable. Among the variations of normal lipoprotein pattern, the most interesting was those with dense and wide midband in addition to normal beta lipoprotein band. Some of them showed hypercholesterolemia and some others showed hypertriglyceridemia. Following drug therapy for hyperlipidemia, quantitative and qualitative changes of serum lipoprotein profiles were observable frequently.
These observations suggest that serum lipid abnormalities may appear as variable forms of abnormal spectra of lipoprotein species, although there is a rough interrelationship between serum lipoprotein abnromalities and lipid abnormalities.

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高血圧患者の腎機能を総合的にみるために腎機能表を考え,腎血流量,腎血漿流量,糸球体濾過値,濾過率の値を排列して,観察した結果高血圧患者においては一連の腎機能障害の型があることをみた.そうしてその分類を試み,正常型, L型I, L型II, L型II A, L型III B,くの字型の6型に分類した.これらの型にしたがつて本態性高血圧,腎性高血圧をみれば,おのおの腎機能表に記載した諸検査成績及び血圧,血清総コレステロール値,ヘモグロビン量等と有意な相関関係をしめした.又治療による腎機能の変動を観察すれば,正常型, L型I, L型II, L型III Aを示す症例では改善例が多くみられたのに反し, L型III B,くの字型を示した症例では改善例はほとんどなく不変または惡化した。このように総合的に腎機能を観察し,一連の腎機能障害の型を考えることが高血圧症における病態,治療効果,予後をみる上にきわめて有意であることがわかつた.さらに心拍出量,全末梢血管抵抗を測定し,体循環と腎循環との関係をみた.

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The effects of ubiquinone (Coenzyme Q₁₀) on plasma renin activity (PRA) and plasma aldosterone (PAL) were studied during the acute respiratory acidosis in the dogs. Our previous studies showed that PRA was increased and. PAL was slightly increased, during the acute respiratory acidosis in the dogs. In the present experiment, PRA was increased in both control group and ubiquinone group, and PAL was increased in control group, but decreased in ubiquinone group, during the acute respiratory acidosis. And also the NaK ratio in urine was decreased in control group but increased in ubiquinone group. We concluded that:(1) Ubiquinone had no direct effect on renin-angiotensin system(2) Ubiquinone suppressed the biosynthesis and release of aldosterone in the adrenal gland.

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調製用ディスク電気泳動法を用い,ヒト血清リポ蛋白質分析用ポリアクリルアミド系によるイヌ血清リポ蛋白質の分離回収を試みた.著者らのゲル系では血清リポ蛋白質をスダン黒によって前染色するが,これがリポ蛋白質各分画の正確な分離と回収を容易なものとした.前染色は分離回収分画のリポ蛋白質としての分析あるいはリポ蛋白質脂質構成の分析の障害とはならないと考えられた.
イヌ血清リポ蛋白質は4種,即ちαリポ蛋白質の亜分画3種(alb,α-1,α-2リポ蛋白質)およびβリポ蛋白質に分離された.イヌ血清リポ蛋白質の基本成分はα-1リポ蛋白質であった.電気泳動分離後のリポ蛋白質およびそれぞれの脂質成分はポリアクリルアミアドゲルから回収され,その後の分析を可能とした.各リポ蛋白質の脂質構成はそれぞれに特徴的であり,リポ蛋白質相互間の鑑別を可能とするものであった.リポ蛋白質相互間の汚染はリポ蛋白質脂質の分析ならびにリポ蛋白質回収分画の免疫電気泳動の結果からみて,たとえあるとしても僅少のものと思われた.しかしながら,イヌ全血清とリポ蛋白質回収分画の抗イヌ・ウサギ血清に対する反応には部分的な不一致がみられ,リポ蛋白質抗原成分の各リポ蛋白質分画への複雑な分布を示唆しているものと思われた.結論として,本報に述べた方法を用いイヌ血清リポ蛋白質についての更に詳しい検討を行ない得るものと考えられた.

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The elements which determine the reliability and stability of a single channel pulse height analyzer are influenced by the change of room temperature when all the circuits are made up of the semiconductors. For the temperature characteristic of semiconductor elements, it is important to discuss the static characteristic that determines the operation point of circuit. The single channel pulse height analyzer is composed of three clippers of the same type and another type clipper. If the D. C. level of two kinds of input signals for the clip points of all the clippers changes similarly by the room temperature, the output signals at the clip points do not change. In this study, the stability within 0.02%/°C on base line and channel width has been confirmed.

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