We sought to clarify the relationship between the physicochemical properties of each medical supply and serious adverse drug reactions listed in the package inserts, by reviewing new information. We investigated 1) 1078 medicines currently available on the domestic Japanese market by using physicochemical data, such as cLogD, molecular weight (MW), and pK_a and 2) the serious adverse drug reactions stated in the package inserts and the presence or absence of serious renal and liver disorders, as well as mental, extrapyramidal, and skin disorders. The renal disorders data showed: cLogD<0, adjusted odds ratio ()=2.00; MW values ≥500, =2.28; and pK_a<7.4, =1.95-2.06. The liver disorders data showed: pK_a<8.4, =1.83-1.95, and MW values ≥300, =1.47-1.87. The mental disorders data showed: cLogD≥0, =2.12, and MW values<400, =2.46-2.85. The extrapyramidal disorders data showed: pK_a≥6.4, =4.50-11.32; cLogD≥0, =4.71; and MW values<500, =7.95-15.08. The skin disorders data showed: cLogD<0, =1.46; MW values ≥500, =1.69; and pK_a<6.4, =1.65 or<7.4-8.4, =1.59. This information will be useful for investigating the relationships between new drugs entering the market and their potential future adverse drug reactions, and for establishing both precautionary and medical observational standards.

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　組織学的絨毛膜羊膜炎（hCAM）が短期予後に与える影響について，極低出生体重児17,806名を検討した．hCAMの有無で2群に分類し，その後在胎週数のグループ毎に分けて短期予後を比較した．またBlanc分類のStage毎に4群に分けて短期予後を比較した．在胎22〜30週ではhCAM群は呼吸窮迫症候群（RDS）の調整オッズ比（

）は低く，慢性肺疾患（CLD），在宅酸素療法（HOT）のは高かった．在胎22〜27週ではhCAM群は死亡退院のは低く，在胎28〜30週では脳室周囲白質軟化症，敗血症のは高かった．またBlanc分類のStage 3はRDS，動脈管開存症（PDA）のが低く，CLD，HOTのが高かった．しかし，Stage 1はPDA，脳室内出血，未熟児網膜症治療のが高かった．hCAMの影響を考える際には児の在胎週数やStageも考慮する必要がある．

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Background: The causative pathogen is rarely identified in the emergency department (ED), since the results of cultures are usually unavailable. As a result, antimicrobial treatment may be overused. The aim of our study was to investigate the pathogens, risk factors of acute gastroenteritis, and predictors of acute bacterial gastroenteritis in the ED.
Methods: We conducted a matched case-control study of 627 stool samples and 612 matched pairs.
Results: Viruses (41.3%) were the leading cause of gastroenteritis, with noroviruses (32.2%) being the most prevalent, followed by bacteria (26.8%) and Giardia lamblia (12.4%). Taking antacids (adjusted odds ratio [] 4.10; 95% confidence interval [CI], 2.57–6.53), household members/classmates with gastroenteritis ( 4.69; 95% CI, 2.76–7.96), attending a banquet ( 2.29; 95% CI, 1.64–3.20), dining out ( 1.70; 95% CI, 1.13–2.54), and eating raw oysters ( 3.10; 95% CI, 1.61–5.94) were highly associated with gastroenteritis. Elders ( 1.04; 05% CI, 1.02–1.05), those with CRP >10 mg/L ( 2.04; 95% CI, 1.15–3.62), or those who were positive for fecal leukocytes ( 2.04; 95% CI, 1.15–3.62) or fecal occult blood ( 1.97; 95% CI, 1.03–3.77) were more likely to be hospitalized in ED. In addition, presence of fecal leukocytes (time ratio [TR] 1.22; 95% CI, 1.06–1.41), abdominal pain (TR 1.20; 95% CI, 1.07–1.41), and frequency of vomiting (TR 0.79; 95% CI, 0.64–0.98) were significantly associated with the duration of acute gastroenteritis. Presence of fecal leukocytes ( 2.08; 95% CI, 1.42–3.05), winter season ( 0.45; 95% CI, 0.28–0.74), frequency of diarrhea ( 1.69; 95% CI, 1.01–2.83), and eating shrimp or crab ( 1.53; 95% CI, 1.05–2.23) were highly associated with bacterial gastroenteritis. The area under the receiver operating characteristic curve of the final model was 0.68 (95% CI, 0.55–0.63).
Conclusions: Acute bacterial gastroenteritis was highly associated with season, frequency of diarrhea, frequency of vomiting, and eating shrimp or crab.

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Objectives : Many stroke patients experience motor and cognitive dysfunctions that make living at home challenging. We aimed to identify the factors associated with hospital discharge to home in older stroke patients in convalescent rehabilitation wards where intensive and comprehensive inpatient rehabilitation are performed following acute-phase treatment.

Methods : A retrospective cohort study was conducted among 1227 older stroke patients registered in the database of the Council of Kaga Local Stroke Network, Japan, between 2015 and 2019. Patients’ basic characteristics, discharge destination, type and severity of stroke, cognitive status, and activities of daily living (ADL) including continence were evaluated.

Results : The proportion of subjects discharged to home was 62.3%. The mean hospital stay in the home discharge group was shorter than that in the non-home discharge group (111 days vs. 144.6 days, P <0.001). The following factors were associated with discharge to home: age (adjusted odds ratio [

]: 2.801, 95% confidence interval [CI] [1.473, 2.940]; P <0.001), sex (: 1.513, 95% CI [1.112, 2.059]), stroke type (: 1.426, 95% CI [1.013, 2.007]), low cognitive status (: 3.750, 95% CI [2.615, 5.379]), low level of bladder control (: 2.056, 95% CI [1.223, 3.454]), and low level of bowel control (: 2.823, 95% CI [1.688, 4.722]).

Conclusions : Age, sex, stroke type, cognitive function, and ADL scores for bladder and bowel control were associated with discharge to home. Improving continence management regarding both voiding and defecation may be a promising care strategy to promote hospital discharge to home in older stroke patients.

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The coronavirus disease 2019 (COVID-19) pandemic remains a global public health concern. The clinical course and risk of developing severe illness among patients with COVID-19 who are at low-risk of severe COVID-19 remain uncertain. This retrospective cohort study from an isolation facility for low-risk COVID-19 patients in Japan evaluated the potential risks for severe disease with hypoxia (SpO₂ ≤ 93%) or experiencing prolonged isolation period longer than 14 days with persistent acute symptoms. The study was performed before the spread of the alpha variant in the country and before the start of a nationwide mass vaccination campaign against COVID-19. Among the 929 participants with reliable outcome data regarding the development of hypoxia, 63 (6.8%) developed severe disease with hypoxia during their stays at the facility. Higher age [adjusted odds ratio (

), 1.08; 95% confidence interval (CI), 1.06-1.10] and male sex (, 4.70; 95% CI, 2.39-9.22) were associated with this outcome. As for the experience of prolonged isolation period, higher age (, 1.02; 95% CI, 1.01-1.04), atopic diseases (, 1.69, 95% CI, 1.09-2.64), presence of cough at onset (, 1.64; 95% CI, 1.09-2.48), and prescription of oral antibiotics before positive test results for COVID-19 (, 2.37; 95% CI, 1.33-4.22) were associated with this outcome. In summary, 5-10% of low-risk COVID-19 patients later develop hypoxia. Older age and male sex were associated with both the development of hypoxia and prolonged acute symptoms. The unnecessary prescription of antibiotics before COVID-19 diagnosis may prolong COVID-19 symptoms.

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Background:The characteristics of aortic elasticity are unclear in children with connective tissue disorders (CTDs) such as Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS), especially in those with a non-dilated aortic root (

). This study evaluated the aortic elasticity properties of pediatric MFS and LDS patients with either dilated or non-dilated .

Methods and Results:The 31 children with MFS or LDS were classified into dilated (Z score of

diameter ≥2.5; n=17) or non-dilated (Z score of diameter <2.5; n=14) groups and compared with controls. Using transthoracic echocardiography, we analyzed the aortic elasticity parameters of distensibility, strain, and stiffness index at the levels of the , sinotubular junction, ascending aorta, and descending aorta. Aortic distensibility and strain were significantly lower in both test groups than in controls at the level. The Z score of diameter significantly correlated with aortic distensibility (R=–0.63, P<0.001), strain (R=–0.54, P=0.002), and stiffness index (R=0.52, P=0.002) in the patients’ groups. Multivariate analysis revealed that aortic distensibility and the type of CTD were independently associated with dilatation.

Conclusions:Aortic elasticity at the level of the

may be decreased in children with MFS or LDS even before dilatation progresses. Less aortic distensibility and CTD type are considered important parameters in estimating dilatation in these patients. (Circ J 2016; 80: 2369–2375)

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Background: Customarily, bedrooms in Japan are left unheated. Although several studies have reported that the use of a heating system has positive outcomes on respiratory infection and asthma, the preventive effect of heating systems against infectious diseases in children is not well known.

Methods: We conducted a cohort study using two questionnaire surveys, one before the winter season in November, 2018 and the second after winter in March, 2019. Participants were 155 children who did not use a heating system in the bedroom and 156 children who did.

Results: Having a heated bedroom with a heating system was associated with decreased odds for the frequency of cold (≥3 times) (adjust odds ratio [

] 0.35; 95% confidence interval [CI], 0.19–0.65), duration of fever (≥3 days) ( 0.38; 95% CI, 0.22–0.66), duration of medicine for a cold (≥3 days) ( 0.91; 95% CI, 0.87–0.95), hospital visit due to cold (≥3 days) ( 0.54; 95% CI, 0.31–0.94), absence from school or nursery (≥3 days) ( 0.43; 95% CI, 0.27–0.70), influenza infection ( 0.43; 95% CI, 0.26–0.71), and gastroenteritis ( 0.39; 95% CI, 0.21–0.72). Influenza vaccination reduced the odds of influenza infection ( 0.36; 95% CI, 0.22–0.59) and absence from school or nursery (≥3 days) ( 0.62; 95% CI, 0.39–0.99).

Conclusion: This study implies that the heating of bedrooms may have a preventive effect against infections among children. Broader dissemination of this knowledge in Japan will require cultural change through public health awareness.

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This study aimed to determine the prevalence and predictive factors of fear of COVID-19 and serious mental distress among teachers in public schools of Southern Tunisia. This was a cross sectional study among a representative sample of 525 teachers. The level of Fear was assessed using the Fear of COVID-19 Scale (FCV-19S). A high level was defined as an FCV-19S ≥ 22. Kessler 6 (K6) was performed to predict serious mental distress. Serious mental distress was defined as a K6 score ≥ 13. The prevalence rates of high level of fear of COVID-19 and serious mental distress were 32.8% and 63.8%, respectively. Independent factors associated with a high level of fear of COVID-19 were female gender (Adjusted odds ratio ()=1.6 [1.1-2.5]), chronic disease (=1.6 [1.1-2.4]), home-living children (=3.3 [1.4-7.8]), and poor material working conditions (=1.5 [1.2-2.1]). The high level of fear of COVID-19 (=3.1 [1.8-5.1]) was independently associated with serious mental distress. Living in a rural area (=0.4 [0.3-0.8]), previous COVID-19 infection (=0.5 [0.4-0.8]) and going to school on foot (=0.3 [0.2-0.51]) were independently associated with a lower prevalence of serious mental distress.

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Vestibulospinal reactions in the stepping test with pressure applied to the external auditory canal (-300, -200, -100, 100, 200, 300 mmH₂O) were examined in 20 patients with Meniere's disease refered to our clinic from November, 1988 to August, 1989. The angle of rotation of the body around its vertical axis (), the direction of displacement (DOD), and the distance of displacement (POD) from the original position were measured and compared with the results in 59 normal subjects.
1) Marked deviations in were seen in 10% of the Meniere's disease patients ; the DOD and POD results were within normal limits. The ears showing marked deviations in had normal caloric responses.
2) No meaningful correlations were found between the results and those of electrocochleography and glycerol testing.
3) Statistically significant correlations were found between deviation and both duration of disease and the time since the last attack of vertigo.
4) deviation provides a useful indication that Meniere's disease is in the active stage.

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Background: Little is known about the association between the anxiety toward the effects of radiation on reproduction caused by the Fukushima nuclear accident and the birth rate of people in Fukushima. Therefore, we examined changes and associated factors of future pregnancy intention among mothers in Fukushima Prefecture.

Methods: Using data from three postal surveys among women who registered their pregnancies in the prefecture (N = 6,751 in 2012, N = 6,871 in 2013, and N = 6,725 in 2014), we analyzed the factors associated with women’s intention of future pregnancy using multivariable logistic regression models.

Results: The proportion of mothers with pregnancy intention increased from 53.5% in 2012 to 57.9% in 2014, especially among multiparas (P for trend <0.001). Factors inversely associated with pregnancy intention of both groups were older maternal age (adjusted odds ratio [

] 0.92 for primipara and 0.87 for multipara), poor subjective health ( 0.75 and 0.81, respectively), and presence of depressive symptoms ( 0.71 and 0.79, respectively) (P < 0.01 for all items). In addition, not living with husband ( 0.24), dissatisfaction with obstetrical care ( 0.89) and child abnormalities ( 0.72) were inversely associated with pregnancy intention among primiparas, while receiving infertility treatment ( 2.05) was positively associated among multiparas (P < 0.01 for all items). A separate analysis of 2012 and 2013 data showed that concern about radiation contamination of breast milk was associated with pregnancy intention among primiparas ( 0.61, P < 0.001).

Conclusions: Mothers’ concern about radiation was associated with lower pregnancy intention, especially among primiparas. Providing quality obstetrical and mental health care and parenting support may be the keys to maintaining the temporal increase in fertility.

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak posed impact on healthcare. This study evaluated the effect of SARS-CoV-2 outbreak on the outpatient visits of patients with type 2 diabetes and determined the most affected groups. We analyzed Taiwan’s National Health Insurance data, including 1,922,702 patients diagnosed with type 2 diabetes from 2018 to 2021. Group-based trajectory modelling identified four distinct outpatient visit patterns, namely, consistently high (Group 1, 74.2%), low-to-high (Group 2, 8.1%), high-to-low (Group 3, 6.0%) and consistently low (Group 4, 11.7%) utilization. Logistic regression was used to analyze correlations between trajectory types and patients’ demographics and health statuses. Group 3 members had higher odds of being male [adjusted odds ratio (

) = 1.04, 95% confidence interval (CI) 1.03-1.05] and earning below 20,000 New Taiwan Dollar monthly ( = 1.29, 95% CI 1.26-1.31) than those in Group 1. However, they were less likely to be under 80 years old ( = 0.70-0.97), from lower median family income regions ( = 0.81-0.89) or possess a Charlson Comorbidity Index score > 2 ( = 0.67, 95% CI 0.66-0.68). Patients with lower income in affluent areas displayed the highest likelihood of falling into Group 3. Patients with type 2 diabetes and low income from wealthy areas were vulnerable during the pandemic. This result emphasizes the need to target resources and support for this subgroup during such crises.

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Telemedicine has significant potential for helping workers access medical treatment. To improve workers’ access to telemedicine, it is important to analyze current utilization rates and influencing factors. Therefore, the purpose of this study is to evaluate the associations between occupational factors and telemedicine use. A 1-year follow-up study of 4,882 full-time workers receiving regular treatment in Japan was conducted from December 2020 to December 2021. Occupational factors associated with the use of telemedicine were evaluated by multivariate logistic regression analysis. In total, 191 participants had experience of using telemedicine (3.9%). The most common comorbidity was hypertension (37.0%), followed by back pain and arthritis (19.8%) and depression and psychiatric disorders (14.5%). Managers and executives [adjusted odds ratio (

) = 1.92, 95% confidence interval (CI): 1.68-3.43, P < = 0.026], finance industry workers ( = 2.61, 95% CI: 1.24-5.49, P = 0.011), and individuals with experience of teleworking ( = 2.08, 95% CI: 1.52-2.85, P < 0.001) were more likely to use telemedicine. Telemedicine usage was least common among workers aged 50-59 years ( = 0.35, 95% CI: 0.22-0.57, P < 0.001) and those with long working hours (≥ 9.0 hours/day) ( = 0.59, 95% CI: 0.38-0.93, P < 0.022). The utilization rate of telemedicine in Japan is still low. This study identified occupational factors related to the use of telemedicine, such as worker’s age, employee status, working hours, and experience of teleworking. Our findings suggest that flexible work arrangements could promote widespread use of telemedicine.

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　近年,腹部大動脈への人工血管置換手術後の合併症であるaortoenteric fistula(以下AEF)が注目されて来ている.われわれはAEFの一つであるaortoduodenal fistula(以下ADF)を内視鏡的に診断し得た.症例は72歳男性で,腹部大動脈に人工血管置換手術をうけた既応があり,下血を主訴に入院した.内視鏡検査にて,十二指腸第III 部に周堤を伴う潰瘍を認め,経過とともに,同部に拍動と新鮮出血を見るようになり,ADFと診断した.手術では,大動脈周囲は炎症性に一塊となり,人工血管中枢側吻合部と十二指腸第III 部とに交通を認めた.upper GI series,aortogram,腹部CTなどは診断に直接役立たず,病変の存在を示唆するにとどまった.診断のためにはこの疾患を認識することがまず大切で,腹部大動脈に人工血管置換手術をうけた患者で消化管出血が持続する場合は,ADFを疑って早期に内視鏡的に,食道から十二指腸第IV部までを観察することが重要であると痛感したので報告する.

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Objectives: We examined whether selected factors were associated with activity limitation used to calculate the healthy life expectancy in accordance with the target of Health Japan 21 (the second term).
Methods: Data for 6251 subjects were obtained from the Comprehensive Survey of Living Conditions and the National Health and Nutrition Survey, both of which were conducted by the Ministry of Health, Labour and Welfare of Japan in 2010. The age-adjusted odds ratios () of limitation of activity for the assessed factors were estimated using a logistic model.
Results:, The percentage of persons with activity limitation was 12.1% of men and 15.6% of women. For men, low body mass index (BMI) (: 2.02, p=0.008), high blood pressure (: 1.53, p=0.021), high hemoglobin A1c (HbA1c) (: 1.99, p=0.000), a small number of steps (: 1.68, p=0.002), and high intake of salt (: 0.69, p=0.010) were significantly associated with limitation of activity. For women, high BMI (: 1.49, p=0.003), a small number of steps (: 1.48, p=0.009), and high intake of salt (: 0.77, p=0.017) were significantly associated with activity limitation.
Conclusion: We identified several factors that were associated with activity limitation. Our results from cross-sectional data require careful interpretation before concluding whether these relationships are causal

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【背景と目的】腸管気腫症（Pneumatosis intestinalis :PI）は、消化管壁に多発性の含気性嚢胞が集簇する希少疾患である。今回、厚生労働科学研究費補助金難治性疾患等克服研究事業の支援により、本邦におけるPIの実態を調査した。【方法】全国多施設共同疫学調査のアンケート調査項目は患者の性、年齢、既往歴、服用薬剤、病変部位、腸管合併症（絞扼・壊死、腸閉塞、麻痺性イレウス、敗血症、ショック、大量消化管出血）、治療。紙媒体によるデータ収集を行った。【結果】全国150施設にアンケート調査を依頼し、48施設（32％）から167例のPI患者が登録された。多変量解析の結果、高齢者（補正オッズ比[

]: 1.05、P= 0.0053）および慢性腎臓病（: 13.19、P= 0.0468）が小腸に病変を有するPIの独立した予測因子であった。重篤な合併症は、小腸大腸型（: 45.49、P<0.0001）および小腸型（:7.90、P= 0.0042）に関連していた。酸素吸入療法は腸閉塞の既往（: 13.77、P= 0.0288）に施行され、手術は合併症のあるPIに施行されていた（: 8.93、P= 0.0408）。降圧剤使用（: 12.28、P= 0.0439）と合併症のあるPI（: 11.77、P= 0.0453）はPI増悪に関連していた。合併症のあるPIは唯一死亡に関連していた（OR: 14.40、P= 0.0425）。【結論】小腸に病変を有する小腸型および小腸大腸型PIは重篤な合併症および予後不良因子であることが示された。

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Objective: To clarify the background difference between drug-induced photosensitivity and ultraviolet-visible absorption spectrum or structure and to construct useful information for prevention and prediction of drug-induced photosensitivity.
Methods: We investigated whether, for 457 drugs for which the ultraviolet-visible absorption spectrum is listed in the Japanese Pharmacopoeia, there were absorption maxima in the UVA (320 nm or more and less than 400 nm), UVB (280 nm or more and less than 320 nm), or UVA and UVB (280 nm or more and less than 400 nm). Structure was investigated for the existence of “conjugated”, carbonyl, sulfone, nitro and fluorine. The case drug group was taken to be those drugs for which photosensitivity was listed as a side effect on the medical drug package insert. Using statistical software, SPSS statistics ^® 24 (IBM), we performed univariate logistic regression analysis, and multivariate logistic regression analysis with a stepwise increment method (likelihood ratio) combining items with p＜0.2, and calculated the odds ratio (hereinafter:

). The significance level was taken as 0.05.
Results: There were 85 drugs in the case drug group, and 372 drugs in the control drug group. As a result of multiple logistic regression analysis, in Model 1, we placed sulfone (: 4.55, 95% C.I.: 2.22-9.35), fluorine (: 3.66, 95% C.I.: 1.82-7.39) and nitro (: 4.46, 95 % C.I.: 1.73-11.48) in this order. In Model 2, we placed sulfone (: 4, 40, 95% C.I.: 2.12-9.15), fluorine (: 3.81, 95% C.I.: 1.87-7.76), UVA (: 2.40, 95% C.I.: 1.37-4.18) and nitro (: 3.61, 95% C.I.: 1.39-9.40) in this order.
Conclusion: When a drug is developed, its ultraviolet-visible absorption spectra and structure become clear, and from this information,measures can be taken which bear the potential risk of photosensitivity in mind.

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Objective: Dengue fever is a significant public health problem in Nepal, and police personnel are considered to play a crucial role in preventing and controlling dengue fever. This study aimed to assess the factors that influence the knowledge, attitudes, and practices of police personnel toward dengue in Kathmandu, Nepal.

Methods: The study design was a descriptive cross-sectional study among 422 police personnel, where data were collected using self-administered questionnaires. Bi-variate analysis and multivariate analysis were used to examine the association between sociodemographic factors and environmental factors with knowledge, attitude, and practices of dengue.

Results: The study found that the knowledge, attitude, and practice toward dengue prevention was 58%, 46%, and 75%, respectively. The study found that family history of dengue (

 = 2.78, 95% CI = 1.38-5.6), owning bed nets ( = 2.13, 95% CI = 1.04-4.35) and having covered water storage containers ( = 2.99, 95% CI = 1.74-5.13) were associated with higher odds of knowledge on dengue. Having family history of dengue ( = 2.45, 95% CI = 1.24-4.87) and the presence of broken glasses or discarded plastic bottles in the house ( = 2.07, 95% CI = 1.93-5.36) were associated with attitude on dengue. Knowledge on dengue was associated with higher odds of attitude ( = 3.3, 95% CI = 2.09-5.36) and practices ( = 3.21, 95% CI = 1.93, 5.36).

Conclusion: The study identified specific factors associated with knowledge, attitude, and practices toward dengue prevention. The study concluded that regular training and awareness-raising activities are needed to improve their knowledge, attitudes, and practices toward dengue.

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The maximum limit on overtime working hours for physicians will be applied from 2024. To explore sociodemographic and work-related factors influencing overtime work among cardiovascular surgeons (CS) in Japan. This cross-sectional study included 607 CS who responded to an online survey. Working hours were categorized into ≤60 hours, 60–79 hours, and ≥80 hours per week according to Japan Ministry of Health, Labour and Welfare. Adjusted odds ratios (

) were calculated using a multinomial analysis with stepwise reduction after adjustment for potential confounders. Compared to ≤60 hours, significant factors related to 60–79 hours and ≥80 hours per week were age groups of 30s to 50s versus 60s (: 7.48–3.22 and 23.64–4.87), management with cardiovascular drugs (: 1.87 and 5.80), and postoperative wound management (: 0.47 and 0.16), respectively. Significantly related informed consent for surgery (: 3.29) was seen in 60–79 hours. Contrarily, CS who worked for ≥80 hours took on-duty 5 times or more per month (: 3.89), performed night or holiday calls 20 times or more per month (: 2.26), and attended the intensive care unit (: 3.12). These findings suggest that younger, and some non-surgical work-related factors could influence long working hours among CS.

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Recovery of uranium from natural seawater by a circulating fluidized-bed adsorber (CFBA) was carried out using an organic adsorbent-a granular amidoxime resin (). In the adsorption experiments, stability of the circulating fluidized state of adsorbent and uranium uptake were measured as a finiction of adsorption time. Results were compared with those obtained for a typical inorganic adsorbent-hydrous titanium oxide granulated with polyacrylonitrile (PAN-HTO). The circulating fluidized state of was very stable. The total amount of carried-over adsorbent was small enough for an adsorption period of 216 hours. The uranium adsorption rates of increased linearly up to the adsorption time of 100 hours, but the increase rate decreased slightly after this time. The uranium amount adsorbed per unit weight of was larger than that of PAN-HTO. The effect of contacting section height of the CFBA on the uranium uptake was also discussed.

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可変的前処理付き一般化共役残差法の内部反復の解法にSuccessive Over-Relaxation method (SOR法)を適用することが有効であると知られている.そこで,SOR法を拡張した解法であるAccelerated Over-Relaxation method(法)に着目し,本論文では法がSOR法より演算量が多いという問題点に対して,法の演算量を削減した実装版を提案する.そして,それを内部反復の解法へ適用する.

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