The TMIG (Tokyo Metropolitan Institute of Gerontology)-2DPAGE has been improved to achieve efficient proteome data exchange among collaborative research community. We developed an integrated XML viewer and the XML database system (PHP + PostgreSQL) for 2DPAGE. And we further optimized our TMIG-XML format for data sharing in the user community. The format is designed with 2 layers of the two-dimensional electrophoresis gel information and spot information in the gel images. It has the locale information of the spots. The clickable imagemap functions for the representation of the spot information are both available in the XML database system with PHP and in the viewer with (Delphi 7.0). Individual spots on an experimental gel image are easily matched to corresponding spots on our standard gel image of our TMIG-2DPAGE proteome database using the viewer. The viewer must be the efficient collaborative tool in the user community. The viewer and the database system both allow the user to click on the spots on the gel image to obtain the appropriate entry in the major sequence databases. Moreover the TMIG-2DPAGE database client and the private TMIG-2DPAGE in the TMIG's intranet as the simple laboratory information management system will be constructed. The additional format with the project information, the worker information and time-stamp of major items will be imported to the expanded TMIG-XML format.

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We developed a collaborative proteomics framework with XML-based 2DPAGE database and XML viewer optimized for the proteome database. Prior to the development of the framework, we optimized the XML format of our TMIG-XML-2DPAGE database for efficient data sharing in a collaborative research community. The data format is comprised with 2 layers of 2-D gel map and spot protein information. The function of clickable imagemap for representing spot protein information is available both in the proteome data management system with PHP and in the XML viewer with . Individual spots on an experimental 2-D gel image are easily matched to corresponding spots on a standard 2-D gel map in the TMIG-XML-2DPAGE database using the function of the XML viewer.

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In education on medical- or medical-related disciplines, effective student practice is acutely important. A computer-aided practice is a possible solution for effective student practice. However, installing laboratory-made applications is troublesome and even can cause security faults. Therefore, other convenient and secure methods are preferable. HTML5, the latest web standard, includes a canvas element that can be programmed in JavaScript language for two-dimensional dynamic drawings. Most modern web browsers, which are installed on computers and mobile devices, support this standard. Utilizing this feature, the study ported the Hodgkin and Huxley membrane model simulators for personal computers or Android devices into HTML5 capable devices and tested it in a student practice and evaluated the students' acceptance for the practice. The HTML5-based simulator readily run on the preliminary testing environments and students' devices (mainly iPhones or iPads) in actual practice. However, increased student involvement through additional interactivity of the application may be required for a better understanding of the topic.

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This paper presents the first step of an overall approach to the integration of design and construction in building construction projects. Its approach relies on the information technology to support members of design and construction teams throughout the project's life cycle. To manage the information correctly in execution of jobs, the authors covered all the items to be considered in view of project management. Character of the supporting tools is discussed around integrated object oriented model. As the primary tool, process model is described with its prototype using .

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We present an improved method for encoding digital information in plastic objects using embedded bulk marking by tightly focused pulses of an infrared nanosecond laser. The marking consists of a machine-readable pattern of laser damage spots in the sub-surface region of the object. Compared to surface marking by printing or laser ablation, this method presents the advantage of improved durability of the code. This easy to implement method is suitable for marking the types of objects or their parts as well as of local positions on their surface. In particular location-aware information encoding using this method would provide novel opportunities to enhance the document security, since it prevents unwanted alteration of the initial data.

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利害や価値観などが互いに対立し, コンフリクト状態にある個人またはグループの意思決定を支援するアプローチに, メタゲーム分析がある。本研究は、メタゲーム分析の構成要素であるオプション、シナリオ、評価基準について検討し、コンフリクトモデルを構築する具体的な方法論を提示した。コンフリクトの均衡解はメタゲームによって得られる。安定性分析アルゴリズムを改善し、意思決定支援システムを開発した。本研究の特色と意義をまとめると、以下のとおりである。1)コンフリクトモデルの構築方法論の提示。既往の関連研究は、方法論やコンフリクト全体の構成要素やオプション・シナリオの定義などを中心として、検討を行うものであり、現状問題と分析手法との結合に関する研究はまだ空白であった。本研究ではオプション・シナリオ・評価基準などのメタゲーム分析の構成要素について、その生成原理、設定ルールおよび調整方法などを検討し、論理的にコンフリクトモデルを構築する方法論を示した。2)コンフリクト問題における定量的評価基準。これまでは発言力など個人的人間関係に影響された評価基準について、問題を階層構造に整理した上で、一対比較法の援用により定量化を行った。3)メタゲームにおける均衡解探索方法の改良。既往研究のメタゲーム解析手法を用い、実際の問題を解決する上で、そのアルゴリズムの冗長性、すなわち次善の解または現実性の低い解の探索に多くの計算資源を用いていることがわかった。本研究では、安定性分析について、探索範囲を最良解に限定して差し支えないことを確認し、計算資源を削減し、新しいアルゴリズムの開発を行なった。4)簡便かつ実用的なシステムの開発。建築プロジェクトでは、コンフリクト問題の解決および組織としての意思決定を迅速に行うことが求められる。本研究では現在のコンピュータの処理技術を前提として、単純な操作で分析の可能なシステムの開発を行った。

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近年, 汎用機からパソコン及びワークステーションへのハードウェアの移行に伴い, アプリケーションソフトウェアも, グラフィカル・ユーザインタフェースをベースとしたビジュアルなイベント駆動型プログラムに変化してきた.一般にこれらのプログラミングは, 従来のテキストベースの手続き型プログラミングに比較して作成が難しいと言われている.それゆえ, そのプログラミング教育についても未だに手探りの状況が続いている.そこで, 本稿では, 短期大学等の情報処理関連学科において, 手続き型プログラミング教育が主流の状況下で, 新しいプログラミングパラダイムに対応したビジュアルなシステム環境におけるプログラミング教育方法の一案を提示するものである.

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目まぐるしく変化するパソコンのプログラミング環境に対して, 大学等の高等教育機関においては, 「何を, どのくらい, どのように」プログラミング教育するか, 明快な解答を得られないのが現状である.32ビットパソコンにおいてMicrosoft社のWindowsが標準的OSとして広く認知されるにしたがい, GUI環境の中でプログラミングするという, まったく新しいパラダイムの誕生がその大きな原因である.今後, GUI環境は無視できないので, GUIプログラミング教育はきわめて重要である.しかし, 卒業研究や演習などでは, GUIプログラミングは不要なばかりか, 数値計算などではかえって効率的な教育が行えないという問題も起こっている.本報告は, 最新のWindows環境を使って, その目的に応じたプログラミング教育の方法をGUIおよび非GUIに分けて提示したものである.同じWindows環境を使っても多様なプログラミング教育が可能であることが確認できたといえる.

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KaiC, a core protein of the cyanobacterial circadian clock, is rhythmically autophosphorylated and autodephosphorylated with a period of approximately 24 h in the presence of two other Kai proteins, KaiA and KaiB. In vitro experiments to investigate the KaiC phosphorylation cycle consume considerable time and effort. To automate the fractionation, quantification, and evaluation steps, we developed a suite consisting of an automated sampling device equipped with an 8-channel temperature controller and accompanying analysis software. Eight sample tables can be controlled independently at different temperatures within a fluctuation of ±0.01°C, enabling investigation of the temperature dependency of clock activities simultaneously in a single experiment. The suite includes an independent software that helps users intuitively conduct a densitometric analysis of gel images in a short time with improved reliability. Multiple lanes on a gel can be detected quasi-automatically through an auto-detection procedure implemented in the software, with or without correction for lane ‘smiling.’ To demonstrate the performance of the suite, robustness of the period against temperature variations was evaluated using 32 datasets of the KaiC phosphorylation cycle. By using the software, the time required for the analysis was reduced by approximately 65% relative to the conventional method, with reasonable reproducibility and quality. The suite is potentially applicable to other clock or clock-related systems in higher organisms, relieving users from having to repeat multiple manual sampling and analytical steps.

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A computational procedure and a software program were developed for three-dimensional (3D) modeling of the rice embryo and of the gene expression of the homeobox gene OSH1. To date, such samples have generally been difficult to analyze three-dimensionally by confocal laser microscopy. Therefore, we performed 3D reconstruction using serial sections. The procedure can be summarized as follows. Serial sections were subjected to in situ hybridization with subsequent digitization of resultant micrographs. Then, two-dimensional (2D) images of sections were realigned by automatic or interactive computation to restore their original 30 positions, which had been destroyed by sectioning. After realignment, data relating to all sections of the embryo and gene expression were extracted according to color differences defined by an HSL (hue, saturation, and lightness) coordinate system with subsequent noise cancellation. The sectional contours of the various regions were connected to generate 30 surfaces by triangulation. Each 3D triangulated frame was subjected to a rendering program, and finally a 3D model of the rice embryo and of expression of the gene examined by in situ hybridization was generated. The resultant 30 model clearly demonstrated down-regulation of expression during the development of the coleoptile and provascular tissue, confirming the usefulness of our 30 modeling technique.

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The analysis of systems' modelling methods, means of models' description and research of software technologies as well, all of those combined led to development of railroad automatic and control simulation models. The complexity of these simulation models is due to the inherently high-tech and multi-level system control technology of the railway stations. The models allow for research of equipment functionality and facility testing. Based on thorough evaluation of implemented algorithms, the simulation model is able to provide practical recommendations pertaining to the improvement of workplace safety. The main concept of simulation model and its artificial world design is creation of multi-layered inter-linked data structure of complex system. This structure consists of such modeling data types as landscaping (textures, altitude maps-either fictional or actual ones, obtained from Geographic Information System), railroad sectors and stations (railway lines and splines, incline maps, signals etc.), railway traffic (facilities and traffic maps), and systems of centralized traffic and dispatch controls. The AutoCAD system was chosen as the main design tool for the development of a railway segment simulation model. CAD is very user-friendly and easy to interact with as it supports OLE (object linking and embedding) and COM (Component Object Model) and contains a rich libraries of component files and prototypes. The training simulator software module uses AutoCAD graph data and creates a database for the imitation model. Other modules adapt the data to the specific systems being modeled. The automation of data structuring, along with a multi-level approach to models' composition, has allowed for more flexibility in the modelling process and eliminated routine procedures associated with data configuration. It has simplified and quickened the process of preparation and tuning the models of those particular railway sections and their tech systems, which really require to be studied and researched.

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共投断層によらない、新しい小断層解析法のためのステレオネットプログラム(Stereonet for Faul-Striation Analysis)を作成した。FDConverterで書式を整えた断層スリップデータを入力すると、データを等角投影するソフトである。断層スリップデータのプロット法は、断層面の方向を大円で表現する方法と、局をプロットして表現する方法の２通りから選択できる。投影図は、enhanced metafile として保存することができる。データから応力を推定するには、一般に複雑な計算にゆだねる必要がある。しかし単純な応力しか記録していない断層郡で、断層面の方向が非常にバリエーションが大きいなら、投影図から応力を推定することもできる。

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Job-shop Scheduling Problem (JSP) is one of the most difficult benchmark problems. GA approaches often fail searching the global optimum because of the deception UV-structure of JSPs. In this paper, we introduce a novel framework model of GA, Innately Split Model (ISM) which prevents UV-phenomenon, and discuss on its power particularly. Next we analyze the structure of JSPs with the help of the UV-structure hypothesys, and finally we show ISM's excellent performance on JSP.

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 近年の放射線治療計画における簡便な検証方法の一つとして，ソフトウェアを用いた独立検証装置が開発されて きた．従来の標準的手法として用いられるクラークソン法は複雑な照射野形状に対応しきれているとはいえないため，新たにレイトレーシング法を導入することで高精度の独立検証装置開発を試みた．照射野面積計算にレイトレーシング法を導入した独立検証ソフトウェアを新規に開発した．照射野の大きさおよび形状によってグループ分けした複数の照射野群について，照射野面積および MU値の精度を，電離箱線量計を用いた実測データとの対比を含めて検討した．
 レイトレーシング法による照射野面積の算出精度はクラークソン法による結果と比較して有意に優れていた．MU値は照射野形状によっては一部実測データと一致しなかった．その改善にはコリメータからの透過線量や被照射体の不均質補正を演算するプロセス追加が大きな役割を果たすと思われる．

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