Studies were made on the influence of B
1 and related compounds thiamine propyldisulfide (TPD) and thiamine allyldisulfide (
TAD
) on nicotine hydrops as well as on B1 metabolism. Stated in the following are the results obtained thereof:
1. B
1 has an extremely weak inhibitory influence on the development of nicotine hydrops after 12th day of incubation, while TPD shows no such influence. The inhibitory influence of
TAD
is between the two.
2. Excretion of B
1 into the allantoic fluid is markedly reduced by the administration of nicotine 3.0 mg.
3. When B
1 was loaded under reduced B
1 excretion, the excretion of B
1 showed an increase in all stages of incubation in contrast to that of the loading of nicotine alone, but there was no comparison with the amount of excretion when B
1 was loaded alone. Similar tendency was also observed with TPD. While, in the case of
TAD
, the total quantity of B
1 excretion on the 15 th day and 18 th day of incubation in the eggs received combined administration was much larger than that of the control.
4. On loading nicotine, the B
1 content of liver showed a remarkable reduce, while the total B
1 content of liver was markedly large on administration of B
1, TPD or
TAD
alone and this ten-dency was stronger in the case of the administration of TPD or
TAD
than that of B
1.
5. Reduce in the B
1 content of liver by the administration of nicotine was alleviated better by the administration of TPD or
TAD
, especially by TPD, than by the administration of B
1.
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