The effect of Zn
2+ to β
2-adrenergic receptor (β
2AR) is experimented in the solution containing Bronchodilator. From the immunohistochemical detection of β
2AR, the result shows the influence of Zn
2+ on drug-receptor interaction in the Zn
2+ containing solution on the human bronchial-epithelial cells. G protein-coupled receptors (GPCRs) are the membrane proteins which transmit extracellular signals into intercellular domain by binding of ligands. Artificial ligands are used as drugs and about 50% of current drugs targets GPCRs. Therefore, it is important to investigate the agents which are bound by GPCRs and the influence by the change of conditions on the binding. The effective ligands of GPCRs for the drugs are indicated less side effect. β
2AR is a kind of GPCRs, which has close relationship with the treatment of asthma. The bronchodilators are the ligands of β
2AR, which activate β
2AR and open the bronchi. However, one of disadvantages of the bronchodilators is that the bronchodilators act on the other receptor, β
1-adrenergic receptor, and can cause the serious heart troubles. Various factors have an influence on the interaction of β
2AR with drugs. Therefore, the experiments under the condition that drugs act on more selectively and effectively is valuable for the safe treatment.
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