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BINDING OF TOBRAMYCIN TO ESCHERICHIA COLI RIBOSOMES: CHARACTERISTICS AND EQUILIBRIUM OF THE REACTION

FRANÇOIS LE GOFFIC, FRÉDÉRIC TANGY, BERNARD MOREAU

The Journal of Antibiotics
1979年 32 巻 12 号 1288-1292
発行日: 1979年
公開日: 2006/04/12

DOI https://doi.org/10.7164/antibiotics.32.1288

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A sample of [^{3H
] tobrarnycin (5
, 000 Ci/Mole) has been synthetized and incubated with
the bacterial ribosome and its subunits. The results obtained show that this antibiotic has
two types of binding sites. The primary one is probably responsible for the inhibition of
protein synthesis whereas the secondary one is probably related to the misreading and reading
tiirough of the messenger RNA.
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CONTINUOUS SHIFTWORKING IN PROCESS INDUSTRIES: DOES FIRM EFFICIENCY IMPLY HIGH HUMAN COSTS?

Cbesseredes HORTS

Journal of Human Ergology
1982年 11 巻 Supplement 号 429-440
発行日: 1982/12/15
公開日: 2011/02/23

DOI https://doi.org/10.11183/jhe1972.11.Supplement_429

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英国における過去半世紀 (1922～1972) 間の冶金用コークスの研究

George W. Lee

燃料協会誌
1973年 52 巻 3 号 171-177
発行日: 1973/03/20
公開日: 2010/06/28

DOI https://doi.org/10.3775/jie.52.171

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HAVE DEOXYSTREPTAMINE AMINOGLYCOSIDE ANTIBIOTICS THE SAME BINDING SITE ON BACTERIAL RIBOSOMES?

FRANÇOIS LE GOFFIC, MARIE-LOUISE CAPMAU, ERÉDÉRIC TANGY, ELIANE CAMINADE

The Journal of Antibiotics
1980年 33 巻 8 号 895-899
発行日: 1980年
公開日: 2006/04/12

DOI https://doi.org/10.7164/antibiotics.33.895

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(^{3H) Tobramycin was used as a probe to determine the relationship between the structure of aminoglycoside antibiotics and their ability to remove this drug from its higher affinity binding site on the ribosome. The dissacharide moieties (neamine, tobramine, gentamine) appeared to have a common binding site, whereas the kanosamine, garosamine and ribose moieties determined the specificity of this binding. Amikacin and butikacin behaved in an anomalous manner in spite of their close structural relationship to tobramycin.
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EFFECTS OF N-ALKYLATION AND N-ACYLATION ON TOBRAMYCIN ACTIVITY

S. SICSIC, J. F. LE BIGOT,
C
. VINCENT,
C
. CERCEAU, F. LE GOFFIC

The Journal of Antibiotics
1982年 35 巻 5 号 574-579
発行日: 1982年
公開日: 2006/04/12

DOI https://doi.org/10.7164/antibiotics.35.574

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The activities of tobramycin derivatives acetylated and ethylated on the 6'-N, 2'-N and
3
-N positions were examined. The MICs of these derivatives against tobramycin sensitive strains indicated that 2'-N-ethylated and 6'-N-ethylated derivatives have a fairly good activity, and confirmed that the
3
-N position is the most important one for antibiotic activity since
3
-N derivatives were less active. The MICs of these derivatives against tobramycin resistant strains, and their inactivation by tobramycin modifying enzymes were examined. These results showed that 2'-N or 6'-N ethylation protects the drug against inactivation by AAC(2') or AAC(6'), respectively, and 2'-N-ethyltobramycin and 6'-N-ethyltobramycin were active against strains containing these modifying enzymes. On the other hand,
3
-N ethylation protects the drug against inactivation by AAC(
3
) but
3
-N-ethyl tobramycin does not inhibit strains containing this enzyme.
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より実用的な飛行機への探求

Grover Loening

日本航空学会誌
1963年 11 巻 119 号 373-380
発行日: 1963年
公開日: 2009/05/25

DOI https://doi.org/10.2322/jjsass1953.11.373

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REPETITIVE LIQUEFACTION AT A GRAVELLY SITE AND LIQUEFACTION IN OVERCONSOLIDATED SANDS

LIVIO SIROVICH

地盤工学会論文報告集
1996年 36 巻 4 号 23-34
発行日: 1996/12/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf.36.4_23

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Repetitive liquefactions in angular and subangular gravels from an alluvial fan, in the case of two earthquakes with accelerations lower than that of a former which had caused liquefaction some months before, are described. The liquefaction took place from the surface, down to a depth of approximately 10 m. Water laden with sediments spouted out for some tens of minutes after the strong motion ceased. Knowledge of the grain size distribution of the sediments inside the body of the alluvial fan roughly defines the areas of the fan prone to future liquefaction. Non-repetitive liquefaction in overconsolidated fine fluvio-lacustrine sand of glacial origin at the unusual depth of 14 m to 16 m is also described. From the observation of sand lifted up for 10 m inside a large diameter well, and of that which spouted out from several microvents, it was estimated that extra-pore pressure was close to lithostatic conditions. Nevertheless, modeling of intrinsic pore pressure buildup on the DESRA2 programme gives lower values than the experimental one. Geotechnical characteristics of the 12 m-thick sandy stratum indicate that the upper part is unusually soft, either due to water circulation or past repetitive liquefactions which prevented reconsolidation. It is suggested that excess pore pressure generated by the earthquake was also due to redistribution of pressure from adjacent sediments.
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Circuit Techniques to Enhance Linearity and Intrinsic Gain to Realize a 1.2V, 200MHz, +10.
3
dBm IIP
3
and 7th-Order LPF in a 65nm CMOS

Yasuhiro SUGIMOTO, Kazuma SAKATOH

IEICE Transactions on Electronics
2013年 E96.C 巻 6 号 867-874
発行日: 2013/06/01
公開日: 2013/06/01

DOI https://doi.org/10.1587/transele.E96.C.867

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Circuit techniques to enhance the linearity of input-voltage-to-current (V/I) conversion and to increase the output impedance of a current source by compensating for the low intrinsic gain of a transistor were introduced to realize a high-frequency operational transconductance amplifier (OTA) for a low supply voltage using sub-100-nm CMOS processes. Applying these techniques, a MOS 7th-order Gm-
C
linear-phase low-pass filter (LPF) was realized using a 65nm CMOS process. A simplified biquad LPF that can serve as a component of a 7th-order LPF was newly developed by replacing OTAs with resistors. As a result, the -
3
dB frequency bandwidth, group delay ripple,
3
rd-order distortion, and
3
rd-order input intercept point (IIP
3
) were 200MHz, 2.2%, ≤ -55dB with a 100MHz input, and +10.
3
dBm, respectively, all with a ±
0
.1Vp-p input signal at each input terminal in the pseudodifferential configuration. The LPF including an output buffer dissipated 60mW in the case of a 1.2V supply. Wide spurious-free dynamic range (SFDR) characteristics were confirmed up to high frequencies.
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MICROSEISM BARRIERS

M. L. GHOSH

Journal of Physics of the Earth
1972年 20 巻 2 号 165-186
発行日: 1972年
公開日: 2009/04/30

DOI https://doi.org/10.4294/jpe1952.20.165

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The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
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虚血性心臟病におけるコレステロール負荷時の血清リポ蛋白変動(第2報)

―特にアポ蛋白Eの変化について―

本間康彦, 三神美和, 佐藤美智子, 石原仁一, 吉川広, 木下栄治, 田川隆介, 星合充基, 古屋秀夫, 井出満, 田辺晃久, 玉地寛光, 兼本成斌, 友田春夫, 中谷矩章, 五島雄一郎

動脈硬化
1984年 12 巻 3 号 599-603
発行日: 1984/08/01
公開日: 2011/09/21

DOI https://doi.org/10.5551/jat1973.12.3_599

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Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL₂ and
HDL₃
were estimated on the
0
th, 7th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
B
,
C
-II,
E
levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL₂ and
HDL₃
were 15.
9
±7.
5
mg/dl (mean±SD), 150.
9
±58.1mg/dl 43.
8
±
9
.6mg/dl, 16.
4
±
5
.
8
mg/dl and 24.
9
±6.
3
mg/dl respectively. Plasma apoprotein A-I, A-II,
B
,
C
-II and
E
levels were 81.7±
22
.
0
mg/dl, 15.1±
5
.
4
mg/dl, 93.7±36.
0
mg/dl,
3
.
83
±1.00mg/dl and
4
.29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-
C
(r=
0
.348), HDL₂-
C
(r=
0
.612) and
HDL₃
(r=
0
.569). Apoprotein
B
correlated with total cholesterol (TC) (r=
0
.610), VLDL-
C
(r=
0
.341), LDL-
C
(r=
0
.726), HDL-
C
(r=
0
.432) and HDL₂-
C
(r=
0
.465). Apoprotein
C
-II correlated with TC (r=
0
.765), TG (r=
0
.679), VLDL-
C
(r=
0
.651), LDL-
C
(r=
0
.461) and HDL₂-
C
(r=
0
.326). Apoprotein
E
correlated with TC (r=
0
.580), TG (r=
0
.575) and VLDL-
C
(r=
0
.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=
0
.468). Apoprotein
B
correlated with apoprotein
C
-II (r=
0
.393). Apoprotein
C
-II correlated with apoprotein
B
(r=
0
.393) and
E
(r=
0
.549). Apoprotein
E
only correlated with apoprotein
C
-II (r=
0
.549).
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Alcaloides de Caryomene olivascens. : Nouvelles Structures Bisbenzylisoquinoleiques

MARIE LAVAULT, ALAIN FOURNET, HELENE GUINAUDEAU, JEAN BRUNETON

Chemical and Pharmaceutical Bulletin
1986年 34 巻 3 号 1148-1152
発行日: 1986/03/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.34.1148

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Nine isoquinoline alkaloids belonging to the protoberberine, proaporphine and bisbenzyl-isoquinoline series were isolated from Caryomene olivascens (Menispermaceae). Four compounds are new : (-)-2-norlimacine (
4
), (-)-caryolivine (6), (+)-1, 2-dehydro-2-norlimacusine (
9
) and N-formylstepharine (
3
). The last one is the first N-formyl derivative to be reported in the proaporphine group. Its biogenetic origin is discussed. Structures were established on the basis of 360 MHz (FT) nuclear magnetic resonance measurements and also by chemical correlation in the case of
3
.
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Ergonomic Issues in the USA

Thomas J. Albin

人間工学
1999年 35 巻 1Supplement 号 31
発行日: 1999/05/01
公開日: 2010/03/12

DOI https://doi.org/10.5100/jje.35.1Supplement_31

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カナダにおける製紙原料供給の現状

増大する資源

E
. F. Boswell

紙パ技協誌
1998年 52 巻 7 号 885-889
発行日: 1998/07/01
公開日: 2009/11/19

DOI https://doi.org/10.2524/jtappij.52.885

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The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
This
ad
hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
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Role of Vitamins
C
and
E
in Regulating Antioxidant and Pro-Oxidant Markers in Preeclampsia

Mohd Suhail, Mohd Faizul Suhail, Hina Khan

Journal of Clinical Biochemistry and Nutrition
2008年 43 巻 3 号 210-220
発行日: 2008年
公開日: 2008/10/31

DOI https://doi.org/10.3164/jcbn.2008067

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We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
B
which comprised preeclamptics who were supplemented their diets with vitamins
C
and
E
. MDA increased from 6.
22
± 2.
8
(placebo) to
8
.48 ± 1.2 (A) and
8
.02 ± 1.
8
nmol/gHb (
B
). NO concentrations were enhanced from 19.
3
±
4
.2 (P) to 23.
8
± 6.
4
(A) and 24.1 ±
5
.
4
μmol/L (
B
). GSH contents were decreased from 10.42 ± 2.81 (P) to
8
.02 ± 2.
92
(A) and
9
.39 ± 1.02 μmol/g Hb (
B
), whereas GSSG concentrations increased from
0
.98 ±
0
.28 (P) to 1.24 ±
0
.29 (A) and 1.08 ±
0
.12 μmol/g Hb (
B
). SOD activity decreased 23% in A and 14% in
B
; GRx decreased 27% in A and
5
.
5
% in
B
; GPx decreased 12% in A and
9
.6% in
B
. Catalase activity, however, increased 27% in A and 29% in
B
as compared to control. Thus, we conclude that the use of vitamins
C
and
E
should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.

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GEOTECHNICAL RECONNAISSANCE STUDY ON DAMAGE CAUSED BY 2001 GUJARAT EARTHQUAKE, INDIA

東畑郁生, PRASAD S.K., 本多剛, CHANDRADHARA G.P.

地盤工学会論文報告集
2002年 42 巻 4 号 77-88
発行日: 2002/08/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf.42.4_77

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The Gujarat earthquake in India occurred in January, 2001, and caused significant damage in the province of Gujarat. The Japanese Geotechnical Society sent a small reconnaissance team to the damaged region after the quake. The present text presents the report from this activity. The major attention of the team was focused on geotechnical aspects of the damage which were related to earthfill dams and harbor land fills. It was found that a significant portion of damage was concentrated in fills resting on soft natural soils. Swedish weight soundings which were conducted at two places demonstrated the existence of such a soft subsoil. From this, it was concluded that amplification of earthquake shaking as well as the permanent deformation in the soft foundation soil induced such kinds of damage as subsidence, cracking, and lateral spreading in overlying artificial fills. For the better seismic resistance of those affected fills during future earthquakes, the improvement of soft subsoil seems essential.
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DYNAMIC RESPONSES OF FLEXIBLE RECTANGULAR FOUNDATIONS EMBEDDED INTO A VISCOELASTIC HALF-SPACE TO OBLIQUELY INCIDENT WAVES

蒋通, 栗林栄一

土質工学会論文報告集
1988年 28 巻 1 号 56-64
発行日: 1988/03/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.28.56

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The boundary element method expanded in frequency domains is presented to analyze the dynamic interaction between an embedded flexible rectangular foundation and soil with consideration of the obliquely incident waves. Numerical results describing the influence of the flexibility of the foundation on the dynamic responses of the foundation due to obliquely incident waves indicate that the flexibility of actual foundations can diminish the reduction of translation responses and increase the rotational responses in the high frequency range. These phenomena are more conspicuous as the embedment ratio is larger and the value of the wave velocity ratio of the soil and the foundation approaches to unity. When the high frequency components of the input ground motion are important and the basement has higher flexibility (for example ₂v_s/₁v_s >
0
.
4
), the analysis method which considers the basement as a rigid foundation may lead to unsafety estimations and the estimation of the flexibility of the foundation is necessary as analysing the effective input motion with consideration of the incident waves.
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地盤構造の急変する地域での表面波の振幅異常

山田善一, 野田茂

土質工学会論文報告集
1988年 28 巻 1 号 143-152
発行日: 1988/03/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.28.143

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電子タバコ用リキッドに含有される
Δ⁹
-および
Δ⁸
-テトラヒドロカンナビノールアセテートの保存時における安定性（第1報）

東坂諒哉, 城克己, 林侑加子, 津村ゆかり

日本法科学技術学会誌
2023年 28 巻 2 号 197-203
発行日: 2023年
公開日: 2023/07/31
[早期公開] 公開日: 2023/04/20

DOI https://doi.org/10.3408/jafst.849

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The stability of
Δ⁹
‒tetrahydrocannabinol acetate (
Δ⁹
‒THC‒OAc) and
Δ⁸
‒tetrahydrocannabinol acetate (
Δ⁸
‒THC‒OAc) in
e
-liquid during storage was investigated.
Δ⁹
‒THC‒OAc liquids in cartridges were stored at 80℃ or 30℃ for 28 days. The relative concentrations of cannabinoids in the liquids were measured by gas chromatography with flame ionization detection.
Δ⁹
‒THC‒OAc decreased during storage at either temperature.
Δ⁹
‒THC, a minor impurity, also decreased.
Δ⁸
‒THC‒OAc liquid in a cartridge was stored at 80℃ for 57 days. The concentration of
Δ⁸
‒THC‒OAc and
Δ⁸
‒THC, a minor impurity, did not change during that time. Cannabinol acetate increased in all liquids, and unknown products were also detected by gas chromatography/mass spectrometry (GC/MS). The
Δ⁹
‒THC‒OAc and
Δ⁸
‒THC‒OAc liquids were subjected to GC/MS to detect representative diluents, glycerol, propylene glycol, and polyethylene glycol 400, but none of these were detected.

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Lighting Hardware

I. F. Davies

Journal of Light & Visual Environment
1984年 8 巻 1 号 1_9-1_20
発行日: 1984年
公開日: 2011/05/20

DOI https://doi.org/10.2150/jlve.8.1_9

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熱力学諸量の測定とその結果を用いた化学熱力学計算によるNi-Mo-
B
およびNi-W-
B

3
成分系状態図の決定

香山滉一郎, 森下政夫, 張国鋒

粉体および粉末冶金
2006年 53 巻 5 号 419-429
発行日: 2006年
公開日: 2006/12/19

DOI https://doi.org/10.2497/jjspm.53.419

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The phase diagrams of the Ni-Mo-
B
and Ni-W-
B
ternary systems in the region of less than 50mol%
B
were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
E₁
:L (1365K, 71.
5
mol%Ni-6.
0
mol%Mo-
22
.
5
mol%
B
)=(Ni)+
Ni₃B
+
NiMo₂B₂

E₂
:L (1355K, 62.
5
mol%Ni-2.
5
mol%Mo-30.
5
mol%
B
)=
Ni₃B
+
Ni₂B
+
NiMo₂B₂

E₃
:L (1445K, 42.
0
mol%Ni-30.6mol%Mo-10.
3
mol%
B
)=(Ni)+NiMo+
NiMo₂B₂

P₁:L (1812K, 34.
9
mol%Ni-42.
3
mol%Mo-
22
.
8
mol%
B
)+MoB=
Mo₂B
+
NiMo₂B₂

P₂:L (1633K, 42.
3
mol%Ni-40.
4
mol%Mo-17.
3
mol%
B
)+Mo=
Mo₂B
+
NiMo₂B₂

P₃
:L (1812K, 53.
5
mol%Ni-33.7mol%Mo-12.
8
mol%
B
)+Mo=NiMo+
NiMo₂B₂

E₁
:L (1622K, 51.
0
mol%Ni-31.6mol%W-17.
4
mol%
B
)=(Ni)+W+
NiW₂B₂

E₂
:L (1260K, 71.
0
mol%Ni-7.
0
mol%W-
22
.
0
mol%
B
)=(Ni)+
Ni₃B
+
NiW₂B₂

E₃
:L (1291K, 65.
4
mol%Ni-
4
.
8
mol%W-29.
8
mol%
B
)=
Ni₂B
+
Ni₃B
+
NiW₂B₂

P₁:L (2115K, 23.
8
mol%Ni-43.1mol%W-33.1mol%
B
)+WB=
W₂B
+
NiW₂B₂

P₂:L (1657K, 48.
9
mol%Ni-33.1mol%W-18.
0
mol%
B
)+
W₂B
=W+
NiW₂B₂

The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
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