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  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • M. L. GHOSH
    Journal of Physics of the Earth
    1972年 20 巻 2 号 165-186
    発行日: 1972年
    公開日: 2009/04/30
    ジャーナル フリー
    The possibility of attenuation of microseismic waves due to the presence of an upward folding of the ocean bottom into the liquid is discussed in this paper. The upward folding of the ocean bottom has been idealized by means of an irregularity in the form of a rectangle intruding into the liquid and the evaluation of the displacement component at any point of the solid medium has been carried out in two stages. First, the change in the incident mode of the surface wave due to the presence of the rectangular irregularity has been determined, and second, the subsequent change of the resulting displacement components due to the termination of the liquid layer and the step change in elevation of the solid medium at the continental margin has been discovered. Finally, numerical calculation has been made to determine the attenuation of the microseismic waves of different periods due to the presence of the rectangular irregularity at the ocean bottom.
  • Philippe Biane
    Publications of the Research Institute for Mathematical Sciences
    1995年 31 巻 1 号 63-79
    発行日: 1995年
    公開日: 2009/04/24
    ジャーナル フリー
  • I.
    F
    . Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • 鹿野 美弘, 櫻井 徹朗, 小松 健一, 山田 浩之, 斉藤 謙一
    Chemical and Pharmaceutical Bulletin
    1990年 38 巻 4 号 1082-1083
    発行日: 1990/04/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new polyacetylene compounds (
    4
    E
    ,
    6
    E
    , 12
    E
    )-1-acetoxy-
    3
    -isovaleryloxytetradeca-
    4
    ,
    6
    , 12-trien-
    8
    , 10-diyn-14-ol (
    B
    ), and (
    4
    E
    ,
    6
    E
    , 12
    E
    )-1-acetoxy-
    3
    -(
    2
    -methylbutyryloxy)tetradeca-
    4
    ,
    6
    , 12-trien-
    8
    , 10-diyn-14-ol (C) have been isolated along with (
    4
    E
    ,
    6
    E
    , 12
    E
    )-1-acetoxy-
    3
    -senecioyloxytetradeca-
    4
    ,
    6
    , 12-trien-
    8
    , 10-diyn-14-ol (A) from Atractylodes Rhizome (Karabyakujutu). The structures of these compounds were determined on the basis of their spectral data.
  • 増大する資源
    E
    .
    F
    . Boswell
    紙パ技協誌
    1998年 52 巻 7 号 885-889
    発行日: 1998/07/01
    公開日: 2009/11/19
    ジャーナル フリー
    The world is in the midst of a huge fundamental shift in fibre supply, demand balances, and policy changes. Governments around the world are introducing policy changes which influence the supply demand balance as the politicians' thoughts are uttered. Government agencies and their bureaucrats are imposing changes on industry even before the legislation is passed by the government in question.
    This ad hoc change process will continue for a time to come until the countries in question show a tough-mindedness with regard to their land use policies. Policies affecting forest areas such as protection areas, Native land claims, the protection of biodiversity and a true goal of sustainable development ; which addresses the combined issues of cultural, environmental, social and economic matters.
    Eventually all of these difficult issues will reach essential closure. Then there will be great new opportunities for investment to meet the growing demand for forest products ; leading to a strengthening competitive position in the more traditional producing areas such as Canada.
  • Daria Kurguzova, Svetlana Serebrova, Alexey Prokofiev, Ludmila Krasnykh, Galina Vasilenko, Marina Zhuravleva, Elena Smolyarchuk, Anton Barkov
    日本薬理学会年会要旨集
    2018年 WCP2018 巻 WCP2018_PO3-5-27
    発行日: 2018年
    公開日: 2020/09/10
    会議録・要旨集 オープンアクセス

    Background

    The differences in conditions of enteric-coated acid-labile drug release and absorption between healthy subjects in bioequivalence studies and gastrointestinal patients in clinical practice can lead to significant differences in gastric stability of original PPIs and generics. Thus, pathologic duodenogastric reflux (PDGR) and the pH increasing within PPIs administration still remain unaccounted for.

    Methods

    Two-stage modified comparative dissolution testing of original omeprazole (OO) and four generics (G1;

    2
    ;
    3
    ;
    4
    ) was performed. At first, we moved drugs from solution with pH 1.
    2
    (1.
    2
    ±0.05) to pH 7.0 (7.0±0.05) and measure concentration of omeprazole in solution by high-performance liquid chromatography. According to our self-developed formula, pH 7 exposure time of resistance to PDGR for omeprazole is
    4
    minutes, i.
    e
    . the active substance should not be released within
    4
    minutes at pH 7. The exposure at the second stage was conducted with pH
    4
    (
    4
    .0±0.05), that imitated gastric pH after PPI administration. And then we also moved drugs to pH 7 with the subsequent measurement of omeprazole concentration.

    Results

    Omeprazole concentrations after

    4
    , 10, 15, 20, 30, 45, 60 minutes in pH 7 solution at the first stage were different for OO and generics. For OO, these values were
    4
    ,7±0,7%; 41,
    4
    ±
    3
    ,0%; 62,
    8
    ±
    4
    ,0%; 79,5±
    2
    ,
    9
    %;
    83
    ,5±
    2
    ,
    9
    %; 81,
    6
    ±
    2
    ,
    9
    %; 80,
    6
    ±
    4
    ,
    4
    %; for Generic1 - 0; 49,
    3
    ±
    9
    ,
    9
    %; 88,
    8
    ±
    2
    ,
    8
    %; 90,
    4
    ±
    3
    ,7%; 88,
    2
    ±
    2
    ,
    2
    %; 87,
    3
    ±
    2
    ,0%;
    85
    ,
    9
    ±1,1%; for Generic
    2
    - 0; 30,
    6
    ±
    6
    ,
    3
    %; 66,7±
    8
    ,
    2
    %; 76,
    4
    ±7,
    4
    %;
    82
    ,
    8
    ±5,
    3
    %; 86,0±
    3
    ,7%; 84,
    6
    ±
    3
    ,
    3
    %: for Generic
    3
    - 80,
    8
    ±
    3
    ,
    6
    %;
    83
    ,5±1,
    9
    %;
    83
    ,
    8
    ±
    3
    ,
    2
    %;
    83
    ,
    3
    ±
    2
    ,7%; 81,
    9
    ±
    2
    ,1%;
    82
    ,1±
    2
    ,0%;
    82
    ,0±
    2
    ,
    4
    %; for Generic
    4
    -
    82
    ,5±1,7%; 84,
    4
    ±0,
    8
    %; 84,
    2
    ±1,
    2
    %;
    82
    ,
    9
    ±0,
    9
    %;
    82
    ,
    9
    ±0,
    9
    %;
    82
    ,
    9
    ±0,
    9
    %;
    82
    ,
    8
    ±1,1%, respectively.

    An analysis of the omeprazole concentration in pH 7 solution at the second stage revealed the following parameters after the same time: for OO -

    4
    ,
    4
    ±0,
    6
    %; 40, 5±
    3
    ,0%; 62,
    8
    ±
    2
    ,0%; 80,0±
    3
    ,1%;
    85
    ,
    4
    ±
    2
    ,
    9
    %;
    82
    ,
    8
    ±
    3
    ,
    4
    %; 80,
    9
    ±
    3
    ,5%; for Generic1 - 0; 67,0±7,
    8
    %; 89,7±
    2
    ,
    3
    %; 91,
    9
    ±
    4
    ,
    3
    %; 89,1±1,
    6
    %; 88,
    3
    ±1,
    4
    %; 87,
    8
    ±1,
    2
    %; for Generic
    2
    - 0; 42,
    2
    ±5,
    6
    %; 75,1±7,
    3
    %; 81,0±
    6
    ,0%; 88,
    4
    ±
    3
    ,
    2
    %; 88,
    6
    ±1,
    3
    %; 87,
    9
    ±1,0%; for Generic
    4
    -
    85
    ,5±0,5%;
    85
    ,
    6
    ±0,5%; 84,7±0,
    9
    %;
    82
    ,7±
    3
    ,0%; 84,
    4
    ±0,
    3
    %; 84,
    4
    ±0,
    3
    %; 84,
    3
    ±0,
    4
    %, respectively. Generic
    3
    release and degradation were completely realized at pH
    4
    .

    Conclusion

    Decreased gastric stability of Generic

    3
    and Generic
    4
    makes PDGR and inhibited gastric acid secretion due to PPIs administration the potential causes of decreased enteric-coated acid-labile drugs stability.

  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with 7 kinds of factors, as follows ; A^^〜=
    B
    +C+D+K+aE+
    bF
    +cG. A^^〜=estimated values of the readership score. 1)
    B
    , C, D, K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into 7 categories. C=pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys.
    2
    )
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into
    6
    kinds of area (
    2
    .5,
    3
    .5, 5, 7, 10, 15) and 15 column means a whole page, about
    2
    ,000cm^
    2
    .
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design.
    3
    ) a,
    b
    , c : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+
    bF
    =A-(
    B
    +C+D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was
    3
    ,541,
    2
    ,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table
    2
    ^* shows the contribution indexes of each factor by
    3
    kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (
    2
    ) Standard deviations of the category values, (
    3
    ) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table
    2
    in the thesis in Japanese. [
    2
    ] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _
    2
    +
    E
    _
    3
    +
    E
    _
    4
    . design elements [table]
    E
    _1,
    E
    _
    2
    ,
    E
    _
    3
    ,
    E
    _
    4
    , these values have the 5 grades, as 0, 1,
    2
    ,
    3
    ,
    4
    and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of
    F
    have also 5 grades, 0 to
    4
    . The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula. c) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table 5-
    4
    , and 5-5 in the thesis in Japanese.
  • C.W. SHOPPEE, R.
    E
    . Lack
    International Symposium on the Chemistry of Natural Products
    1964年 1964 巻 E-9-3
    発行日: 1964/04/12
    公開日: 2017/08/18
    会議録・要旨集 フリー
  • JAN FAJKOS, Jiri Joska, Frantisek Sorm
    International Symposium on the Chemistry of Natural Products
    1964年 1964 巻 E-10-3
    発行日: 1964/04/12
    公開日: 2017/08/18
    会議録・要旨集 フリー
  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • 高木 徹, 林 賢治, 板橋 豊
    日本水産学会誌
    1984年 50 巻 8 号 1413-1418
    発行日: 1984/08/25
    公開日: 2008/02/29
    ジャーナル フリー
    The acetone extracts from three samples of the hepatopancreas of the poisonous scallops obtained on the Okhotsk Coast of Hokkaido Island were fractionated into two parts, hexane soluble fraction (fraction H) and
    85
    % aqueous ethanol soluble fraction (fraction
    E
    ) by partition to two layers. The majortoxic components in the mouse assay of “diarrheic shellfish toxin” by intra-peritoneal injection were found to be free unsaturated fatty acids showed the following toxicity in MU per g, 18:1 n-
    9
    35, 18:
    2
    n-
    6
    83
    , 18:
    3
    n-
    3
    167, 18:
    4
    n-
    3
    83
    , 20:5 n-
    3
    167, and
    22
    :
    6
    n-
    3
    83
    , respectively. Toxicity of the fraction Hin MUper g was much lower than that of the fraction
    E
    . However, the toxicity of the fraction H per 1 g of the hepatopancreas was about twice that of the fraction
    E
    , since the fraction Hwas much more abundant than the fraction
    E
    in the hepatopancreas. The method for the assay of the diarrhetic shellfish toxin must be reexamined by considering the toxic effect of the free unsaturated fatty acids.
  • CHING-CHUAN HUANG
    SOILS AND FOUNDATIONS
    2009年 49 巻 2 号 249-258
    発行日: 2009年
    公開日: 2011/01/27
    ジャーナル フリー
    The correction factor (ηie) for the ultimate bearing capacity of a footing placed adjacent to a slope, taking into account the combined effect of horizontal and vertical seismic loads, represented by horizontal and vertical seismic coefficients, kh and kv, respectively, was derived using a modified Janbu's slice method. The influence of slope angles ‘α’ on the values of ‘ηie’ are studied here. It was found that the values of ηie can be expressed as an exponential function of ‘kh/(1-kv)’ and ‘α’, with a measurable interdependency between ‘α’ and ‘ηie’. The influence of ‘α’ on the value of ‘ηie’ increases as the input value of ‘kh/(1-kv)’ increases. Equations derived based on the analytical results are proposed to account for this effect. Based on the analyses of 11 near-fault seismographers obtained in the 1999 Chi-Chi earthquake in Taiwan, a ratio between the vertical and the horizontal seismic coefficients, λ, of between ±0.25 is suggested for including the combined effect of vertical and horizontal seismic forces in evaluating the seismic bearing capacity of footings located in near-fault areas.
  • CHING-CHUAN HUANG, WEN-WEI KANG
    SOILS AND FOUNDATIONS
    2008年 48 巻 5 号 641-651
    発行日: 2008年
    公開日: 2011/01/27
    ジャーナル フリー
    At present, analytical or empirical formula for seismic bearing capacity of footings adjacent to slopes is not available. This study uses a pseudo-static-based approach in conjunction with rigorous Janbu's slice method to derive analytical values of seismic bearing capacity factors (Nγ) and correction factors for the effects of inertia of soil mass and load inclinations for a rigid footing adjacent to cohesionless slopes. It is shown that both the bearing capacity factors (Nγ) and the correction factors for the seismic bearing capacity of footings placed on level ground derived herein are comparable with those reported in the literature. Empirical equations regarding the effects of slope angles and load inclinations, expressed using generalized forms of those proposed in the literature, are also derived. It is also found that the empirical equations derived in the present study provide values of correction factors in good agreements with the analytical ones, indicating the validity of using these empirical equations for assessing the bearing capacity of rigid footings situated on the slope subjected to pseudo-static seismic loading.
  • Cbesseredes HORTS
    Journal of Human Ergology
    1982年 11 巻 Supplement 号 429-440
    発行日: 1982/12/15
    公開日: 2011/02/23
    ジャーナル フリー
  • 布施川 雄一, 多田 博己, 小熊 利明, 椎名 豊, 玉地 寛光, 半田 俊之介
    動脈硬化
    1996年 23 巻 9 号 545-551
    発行日: 1996/04/10
    公開日: 2011/09/21
    ジャーナル フリー
    The association between apolipoprotein
    E
    (Apo-
    E
    ) polymorphism and the response of plasma cholesterol to dietary therapy (cholesterol intake of less than 300mg/day) was investigated for about
    8
    weeks in 208 nonfamilial hypercholesterolemia patients (
    E
    3
    /
    3
    161,
    E
    4
    /
    3
    47). The baseline lipoprotein concentration and the intake of energy and lipids were not significantly different between subjects with
    E
    3
    /
    3
    and those with
    E
    4
    /
    3
    phenotypes. After the dietary therapy plasma total cholesterol and low density lipoprotein cholesterol were significantly decreased in both phenotype groups (p<0.05). The patients with
    E
    4
    /
    3
    had significantly smaller reductions of LDL-C than the patients with
    E
    3
    /
    3
    . The changes of LDL-C showed a significant difference between the patients with
    E
    3
    /
    3
    and
    E
    4
    /
    3
    by the Kruskal Wallis test (p=0.041). The presence of
    E
    4
    /
    3
    predicted the degree of cholesterol reduction following dietary therapy.
  • MATTHIAS KRONEN, PETER KLEINWÄCHTER, BRIGITTE SCHLEGEL, ALBERT HÄRTL, UDO GRÄFE
    The Journal of Antibiotics
    2001年 54 巻 2 号 175-178
    発行日: 2001/02/25
    公開日: 2008/09/19
    ジャーナル フリー
  • 早野 清治, 白濱 晴久
    日本化学会誌(化学と工業化学)
    1995年 1995 巻 4 号 291-294
    発行日: 1995/04/10
    公開日: 2011/05/30
    ジャーナル フリー
    (
    6
    E
    ,
    9
    E
    )-
    2
    ,
    3
    -エポキシ-
    3
    ,7,11,11-テトラメチルシクロウンデカ-
    6
    ,
    9
    -ジエン(
    2
    )をフムレン1((
    2
    E
    ,
    6
    E
    ,
    9
    E
    )-
    3
    ,7,11,11-テトラメチルシクロウンデカ-
    2
    ,
    6
    ,
    9
    -トリエン)より合成する既知の合成法は実際に牧率が低く合成的に問題がある.さらに,
    2
    の合成はその反応性や物性の研究のために簡単に高牧率で行われることが望まれる.今回,
    2
    の新たな合成法と簡便な精製法を見いだし,
    2
    を高牧率で1から合成することができたので報告する.1のジエポキシ化,続く再結晶により得られたジエポキシド(
    8
    )は二価のチタンにより還元されて,1(273%)と
    8
    (25%)と少量の
    3
    を含む
    2
    を主生成物(42.7%)として与えた.1と
    3
    は原料として再利用できる.
    2
    の精製は1と同様硝酸銀(
    AgNO3
    )錯体の結晶で行い,純粋な
    2
    は1から通算牧率32.0%で得られた.
    2
    の既知方法による合成は
    4
    段階の反応と数回のカラム分離及び10%
    AgNO3
    含浸シリカゲルカラム分離を必要とし牧率が極端に低い.今回,新しい
    2
    の合成法は
    2
    段階の反応で1回のカラム分離と再結晶により高い通算牧率を示す.
  • Misaki Kojima, Takeya Morozumi
    Journal of Health Science
    2004年 50 巻 5 号 518-529
    発行日: 2004年
    公開日: 2004/10/01
    ジャーナル フリー
    Six full-length cDNAs encoding pig cytochrome P450 (CYP) enzymes, CYP1A1, CYP
    2
    A19, CYP
    2
    B
    22
    , CYP
    2
    C33v
    4
    , CYP
    2
    C49, and CYP
    2
    E
    1, were isolated and sequenced. The cDNA sequences of pig CYP1A1, CYP
    2
    A19, CYP
    2
    B
    22
    , CYP
    2
    C49, and CYP
    2
    E
    1 showed high similarity to human CYP1A1 (
    85
    .
    4
    %),
    CYP2A13
    (88.
    6
    %),
    CYP2B6
    (81.1%),
    CYP2C18
    (
    85
    .
    3
    %), and
    CYP2E1
    (
    82
    .5%), respectively, and pig
    CYP2C33v4
    cDNA showed high similarity to rat
    CYP2C23
    (79.
    2
    %). Reverse transcription-polymerase chain reaction (RT-PCR) assays revealed hepatic gene expression of all these pig CYP enzymes: the order of expression was
    CYP2C33v4
    and
    CYP2E1
    >
    CYP2C49
    > CYP1A1 and
    CYP2A19
    >
    CYP2B22
    . In the kidney, the
    CYP2C33v4
    gene was expressed at the same level as in the liver, but the CYP1A1,
    CYP2A19
    , and
    CYP2B22
    genes were expressed at lower levels than in the liver. Little renal gene expression of CYP
    2
    C49 and CYP
    2
    E
    1 was observed. We revealed for the first time the full-length cDNA sequences encoding pig CYP1A1 and five CYP enzymes belonging to the
    CYP2
    gene family, thus making it possible to examine the gene expression levels of these CYP enzymes in pig tissues by RT-PCR.
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