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  • George W. Lee
    燃料協会誌
    1973年 52 巻 3 号 171-177
    発行日: 1973/03/20
    公開日: 2010/06/28
    ジャーナル フリー
  • Grover Loening
    日本航空学会誌
    1963年 11 巻 119 号 373-380
    発行日: 1963年
    公開日: 2009/05/25
    ジャーナル フリー
  • Cbesseredes HORTS
    Journal of Human Ergology
    1982年 11 巻 Supplement 号 429-440
    発行日: 1982/12/15
    公開日: 2011/02/23
    ジャーナル フリー
  • I.
    F
    . Davies
    Journal of Light & Visual Environment
    1984年 8 巻 1 号 1_9-1_20
    発行日: 1984年
    公開日: 2011/05/20
    ジャーナル フリー
  • 財満 鎮雄, 竹内 洋一郎, 入交 裕
    軽金属
    1975年 25 巻 8 号 310-313
    発行日: 1975/08/30
    公開日: 2008/07/23
    ジャーナル フリー
    The modulns of longitudinal elasticity and their temperature dependence in commercial aluminum cast alloys were measured in the temperature range from room temperature (20°
    C
    ) to 250°
    C
    by the resonant frequency method. The results obtained are as follows:
    The modulus of longitudinal elasticity tended to decrease weakly and linearly (the tangent of its decrease, m = (-2.
    4
    --
    3
    .
    3
    ) × 102kg/cm2
    C
    ) with the rise of temperature. Within the range of the experiments, aluminum cast alloys were divided into
    3
    groups, the lst group materials having large moduli of elasticity
    E0
    at room temperature (i.
    e
    .,
    E0
    = (
    7
    .15-
    7
    .25) × 105kg/cm2) were
    AC
    2A-T
    6
    ,
    AC
    3
    A-
    F
    ,
    AC
    4
    A-
    F
    ,
    AC
    4
    A-T
    4
    ,
    AC
    4
    B
    -
    F
    ,
    AC
    4
    B
    -T
    4
    ,
    AC
    8
    A-
    F
    ,
    AC
    8
    A-T
    4
    , etc., the 2nd group materials having intermediate moduli (i.
    e
    .,
    E0
    = (
    6
    .85-
    6
    .98) × 105kg/cm2) were
    AC
    4
    C
    -
    F
    ,
    AC
    4
    C
    -T
    5
    ,
    AC
    4
    C
    -T
    6
    ,
    AC
    4
    D-
    F
    ,
    AC
    4
    D-T
    6
    ,
    AC
    7
    A-
    F
    , etc. and the
    3
    rd group materials showing considerably smaller moduli (i.
    e
    .,
    E0
    = (
    6
    .58-
    6
    .65) × 105kg/cm2) were
    AC
    1A-
    F
    ,
    AC
    1A-T
    6
    ,
    AC
    2A-
    F
    , etc. However, there were some differences between the moduli in this experiments and the moduli in the other data books, and these were considered due to the difference of the measurement principles and of hypotheses or assumptions involved in these principles, so it is suggested that the moduli of elasticity should be reported with indication of the measuring method.
  • 小田切 孝人, 田代 眞人
    ウイルス
    2013年 63 巻 2 号 233-240
    発行日: 2013/12/25
    公開日: 2014/10/31
    ジャーナル フリー
  • 小林 優, 家坂 貴子, 中野 江身子, 平山 耕一郎
    天然有機化合物討論会講演要旨集
    1989年 31 巻 71/P2-1
    発行日: 1989/09/17
    公開日: 2017/08/18
    会議録・要旨集 フリー
    Six new cembranoids sarcophytol P (
    3
    ), R (
    4
    ), S (
    5
    ), K (
    8
    ),
    F
    (11), and T (13) were isolated from the soft coral Sarcophyton glaucum. Sarcophytol P (
    3
    ) was shown to be the 20-hydroxy derivative of the major component sarcophytol A (1), and afforded the cyclization product
    6
    in CHCl_
    3
    at room temperature, in a same way as in 1. Sarcophytols R (
    4
    ) and S (
    5
    ) were correlated to 1, by conversion of its
    7
    R,
    8
    R and
    7
    S,
    8
    S epoxide derivatives. Sarcophytol K(
    8
    ) was a 13, 14-dihydroxycembranoid having a 1
    E
    ,
    3
    Z-diene moiety. The absolute configuration of
    8
    and its 1Z,
    3
    E
    - and 1Z,
    3
    Z-isomers sarcophytol
    B
    (2) and J (10) were determined by circular dichroism study of their bis-p-dimethylaminobenzoate derivatives. Sarcophytols
    F
    (11) and T (13) were 1
    E
    - and 1
    E
    ,
    3
    Z-isomers of 1. Compound 11 showed characteristic broadening of the ^1H-NMR chemical shifts, due to the restricted conformational interconversion. Using the three cembranoids sarcophytols
    F
    (11, 1
    E
    ,
    3
    E
    ), N (15, 1Z,
    3
    Z) and T (13,1
    E
    ,
    3
    Z), spontaneous autoxidation-cyclization, in CHCl_
    3
    ,was examined, in order to compare the stereochemical course of the reaction with that of 1 (1Z,
    3
    E
    ), which affords trans-fused bicyclo[
    9
    .
    3
    .0]tetradecene systems. The 1
    E
    ,
    3
    Z-isomer 13 gave the same cyclization product 18, as in the reaction of 1, even though it is isomeric at
    C
    -1,
    3
    . The 1Z,
    3
    Z isomer 15 gave 19, in consequence of the reversed geometry at
    C
    -
    3
    of 15. The 1
    E
    ,
    3
    E
    -isomer (11) gave the bicyclic product
    22
    , having an antipodal fusion as compared with 19. This was confirmed by PCC oxidation of 19 and
    22
    , giving enantiomeric ketones 23 and 24 respectively. The 1(14)-epoxide 26 was shown to be the immediate precursor of
    22
    , and acounted for the inversion of the geometry at
    C
    -1 of the cyclization product. Compound 26 is isomeric with the epoxide 17 derived from 1. The epoxide 17 is the postulated precursor in the conversion of 13 to 18. It is noteworthy that the mode of antipodal fusion of the cyclopentane rings, in 18 and
    22
    , was controlled by the chirality of the epoxy rings. The
    C
    -14 hydroxyl group participates in the transannular cyclization, but was found not to be the requisite functional group for the reaction. Similar treatment of cembrene
    C
    (30), the parent hydrocarbon of 1, also reacted in CHCl_
    3
    giving the bicyclic product 32.
  • 黒川 美貴雄, 吉田 耕治, 永井 保嵩, 宇野 準
    Chemical and Pharmaceutical Bulletin
    1983年 31 巻 12 号 4312-4318
    発行日: 1983/12/25
    公開日: 2008/03/31
    ジャーナル フリー
    Two new partially saturated tricyclic ring systems,
    6
    ,
    6
    a,
    7
    ,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenz [
    b
    ,
    e
    ] oxepins (
    3
    a and
    3
    b
    ), and -thiepins (
    4
    a and
    4
    b
    ) were synthesized. Compounds
    4
    a and
    4
    b
    were desulfurized to give a pair of isomeric 2-methylbenzoylcyclohexanes (10a and 10
    b
    ). Deuterated
    4
    a and
    4
    b
    (11a and 11
    b
    ) were prepared starting from butadiene-
    d6
    (12). The stereochemical features of
    3
    a (trans),
    3
    b
    (cis),
    4
    a (trans) and
    4
    b
    (cis) are compared with those of 10a, 10
    b
    , 11a and 11
    b
    on the basis of proton nuclear magnetic resonance data.
  • Yasuhiro SUGIMOTO, Kazuma SAKATOH
    IEICE Transactions on Electronics
    2013年 E96.C 巻 6 号 867-874
    発行日: 2013/06/01
    公開日: 2013/06/01
    ジャーナル 認証あり
    Circuit techniques to enhance the linearity of input-voltage-to-current (V/I) conversion and to increase the output impedance of a current source by compensating for the low intrinsic gain of a transistor were introduced to realize a high-frequency operational transconductance amplifier (OTA) for a low supply voltage using sub-100-nm CMOS processes. Applying these techniques, a MOS
    7
    th-order Gm-
    C
    linear-phase low-pass filter (LPF) was realized using a 65nm CMOS process. A simplified biquad LPF that can serve as a component of a
    7
    th-order LPF was newly developed by replacing OTAs with resistors. As a result, the -
    3
    dB frequency bandwidth, group delay ripple,
    3
    rd-order distortion, and
    3
    rd-order input intercept point (IIP
    3
    ) were 200MHz, 2.2%, ≤ -55dB with a 100MHz input, and +10.
    3
    dBm, respectively, all with a ±0.1Vp-p input signal at each input terminal in the pseudodifferential configuration. The LPF including an output buffer dissipated 60mW in the case of a 1.2V supply. Wide spurious-free dynamic range (SFDR) characteristics were confirmed up to high frequencies.
  • 山本 雅史, Abkenar Asad Asadi, 松本 亮司, 根角 博久, 吉田 俊雄, 國賀 武, 久保 達也, 冨永 茂人
    園芸学会雑誌
    2007年 76 巻 1 号 36-40
    発行日: 2007年
    公開日: 2007/03/06
    ジャーナル フリー
    カンキツ主要12種を用いて染色体のクロモマイシン
    A3
    (CMA) 染色を行った.染色体は CMA(+) バンドの有無および位置から
    7
    種類に区分できた.すなわち,CMA(+) を A: 両端および動原体近傍に有する,
    B
    : 一方の端部と動原体近傍に有する,
    C
    : 両端に有する,D: 一方の端部に有する,
    E
    : CMA(+) がない,
    F
    : 動原体近傍に有する,Dst: 付随染色体を有する D 型,である.各種はこれらのうち 2~
    6
    種類の染色体を有し,独自の CMA バンドパターンを示した.
    C
    . medica
    では 2
    B
    +
    8
    D +
    8
    E
    C
    . limon
    では 1
    B
    + 1
    C
    +
    8
    D +
    8
    E
    C
    . aurantifolia
    では 2
    B
    +
    9
    D +
    7
    E
    C
    . aurantium
    では 1A + 1
    B
    + 1
    C
    +
    7
    D +
    8
    E
    C
    . sinensis
    では 2
    B
    + 2
    C
    +
    7
    D +
    7
    E
    C
    . maxima
    では
    3
    A +
    3
    C
    +
    4
    D +
    8
    E
    C
    . paradisi
    では 2A +
    3
    C
    +
    6
    D +
    7
    E
    C
    . ichangensis
    では 2
    B
    + 2
    C
    + 12D + 2
    E
    C
    . latipes
    では 2A +
    5
    C
    +
    8
    D +
    3
    E
    C
    . micrantha
    では 1
    B
    + 11D +
    4
    E
    + 2Dst,
    C
    . macroptera
    では 2
    B
    + 1
    C
    + 11D +
    3
    E
    + 1
    F
    C
    . hystrix
    では
    3
    B
    + 1
    C
    +
    8
    D +
    3
    E
    + 2
    F
    + 1Dst であった.
  • Charles-Henri de NOVION, Paul COSTA
    Journal of Nuclear Science and Technology
    1971年 8 巻 10 号 600-601
    発行日: 1971/10/25
    公開日: 2008/12/19
    ジャーナル フリー
  • Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE
    Agricultural and Biological Chemistry
    1988年 52 巻 12 号 3217-3218
    発行日: 1988年
    公開日: 2006/04/05
    ジャーナル フリー
  • Thomas J. Albin
    人間工学
    1999年 35 巻 1Supplement 号 31
    発行日: 1999/05/01
    公開日: 2010/03/12
    ジャーナル フリー
  • 黒川 美貴雄, 糸川 彰, 松本 純一, 福本 吉久, 月原 冨武
    Chemical and Pharmaceutical Bulletin
    1992年 40 巻 9 号 2270-2274
    発行日: 1992/09/25
    公開日: 2008/03/31
    ジャーナル フリー
    11-Amino-
    6
    ,
    6
    a,
    7
    ,
    8
    ,
    9
    , 10, 10a, 11-octahydrodibebenzo[
    b
    ,
    e
    ]thiepines (
    6
    a-d) and -oxepines (
    7
    a-d) were synthesized by the Leuckart reaction of
    6
    ,
    6
    a,
    7
    ,
    8
    ,
    9
    , 10, 10a, 11-octahydro-11-oxodibenzo[
    b
    ,
    e
    ]thiepines (1a,
    b
    )and -oxepines (2a,
    b
    ) followed by hydrolysis of the reaction products
    4
    a-d and
    5
    a-d, respectively. The four diastereomers, cis(
    6
    a-H, 10a-H)-cis(10a-H, 11-H)
    6
    a and
    7
    a, cis(
    6
    a-H, 10a-H)-trans(10a-H, 11-H)
    6
    b
    and
    7
    b
    , trans(
    6
    a-H, 10a-H)-trans(10a-H, 11a-H)
    6
    c
    and
    7
    c
    , and trans(
    6
    a-H, 10a-H)-cis(10a-H, 11-H)
    6
    d and
    7
    d, were isolated and their configurations and conformations were elucidated by chemical methods together with 1H-nuclear magnetic resonance spectroscopic and X-ray crystallographic analyses.
  • Özkan ASLANTAŞ, Ebru Şebnem YILMAZ
    Journal of Veterinary Medical Science
    2017年 79 巻 6 号 1024-1030
    発行日: 2017年
    公開日: 2017/06/16
    [早期公開] 公開日: 2017/04/27
    ジャーナル フリー

    This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant

    E
    . coli isolates were detected in 95 (
    22
    .2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: blaCTX-M-15 (62), blaTEM-
    1b
    (42), blaCMY-2 (
    22
    ), blaCTX-M-
    3
    (16), blaCTX-M-1 (15), blaOXA-1 (
    9
    ) and blaSHV-12 (
    3
    ) alone or in combination. The most frequently encountered phylogenetic group was group A1 (35.
    8
    %), followed by group D2 (
    22
    .1%),
    B
    1 (15.
    8
    %), D1 (
    9
    .
    5
    %), A0 (
    7
    .
    4
    %),
    B22
    (
    5
    .
    3
    %) and
    B23
    (
    4
    .2%), respectively. PMQR genes, aac(
    6
    ’)-Ib-cr, qnr
    S1 and qnrB10 were detected in 25.
    3
    , 10.
    5
    and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.
    8
    % for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE,
    f17a
    -A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing
    E
    . coli
    clone O25
    b
    :ST131/
    B
    2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing
    E
    . coli
    isolates among dogs in Turkey.

  • 佐藤 敬之輔
    デザイン学研究
    1970年 1970 巻 11 号 45-55
    発行日: 1970/03/30
    公開日: 2017/07/25
    ジャーナル フリー
    [1] The purpose of this reserch is to make clear what type of design can give good effects to win the high readership score. At the begining I had to know what factors decide the readership score, and how to change the quality of the desing into numerical value. I have used the method of multi-dimentional analysis with the help of a computer, and got the estimation formula, with
    7
    kinds of factors, as follows ; A^^〜=
    B
    +
    C
    +D+K+aE+bF+cG. A^^〜=estimated values of the readership score. 1)
    B
    ,
    C
    , D, K : these four factors are given as category values (so we call them); each factor is classified into several categories.
    B
    =week day, classified into
    7
    categories.
    C
    =pages of a newspaper, which are characterized by the kinds of articles, news, and the other reading matters, classified into
    22
    categories. D=kinds of goods and trades of the advertizement, classified into 14 catedories. K=constants, given to each 13 surveys. 2)
    E
    ,
    F
    , G : these factors are given as numerical values. G=area of advertizement, measured by the unit of column in the whole page length, being classified into
    6
    kinds of area (2.
    5
    ,
    3
    .
    5
    ,
    5
    ,
    7
    , 10, 15) and 15 column means a whole page, about 2,000cm^2.
    E
    ,
    F
    are the marks obtained in the design of advertizements.
    E
    =sum of the marks obtained in each design element on the advertizement.
    F
    =the marks obtained on the whole effect of the design.
    3
    ) a,
    b
    ,
    c
    : coefficients Using the above formula with the category values and the coefficients, we can obtain the naked design effect from the actual value A of readership score: aE+bF=A-(
    B
    +
    C
    +D+K+cG). In this research, I used 1,829 data of readership score from 1960 to 1968, being obtained by 13 survevs, spring and autumn twice a year. The sample of size each survey was
    3
    ,541, 2,251, or 200 in the other 11 surveys. Multiple correlation coefficient between the estimated value A^^〜 and the actual value A is 0.951. The table 2^* shows the contribution indexes of each factor by
    3
    kinds of expression-(1) Range : the absolute difference between the maximum and the minimum category values, (2) Standard deviations of the category values, (
    3
    ) Partial correlation coefficient : the relationship between the actual values A and each factors. *see the table 2 in the thesis in Japanese. [2] The important point was in the determination of the values of
    E
    ,
    F
    .
    E
    is the sum of the marks obtained in each design element, classified into four kinds :
    E
    =
    E
    _1+
    E
    _2+
    E
    _
    3
    +
    E
    _
    4
    . design elements [table]
    E
    _1,
    E
    _2,
    E
    _
    3
    ,
    E
    _
    4
    , these values have the
    5
    grades, as 0, 1, 2,
    3
    ,
    4
    and 0 is given to the design that has no attractive effect or no applicable element. And
    E
    obtain the marks of 0 to
    9
    grades as the sum of them. The values of
    F
    have also
    5
    grades, 0 to
    4
    . The principles to determine the values of
    E
    ,
    F
    are as follows : a) The marks obtained of
    E
    ,
    F
    must be the relative values among the each survey, and at the same time, they must have constancy within the same survey-the same elements of design must win the same marks obtained.
    b
    ) They must be determined as to win the highest multiple correlation coefficient, when they are put into the estimation formula.
    c
    ) They must be reasonable. In order to justify them, we must carry many researches on the actual condition. The frequency of accurence of each grade of
    E
    ,
    F
    values, as the table
    5
    -
    4
    , and
    5
    -
    5
    in the thesis in Japanese.
  • ―各成分の組織化学的観察と定量―
    長谷川 元治, 荒井 親雄, 斉藤 光代, 竹内 光吉, 安部 信行, 遠藤 みどり, 高山 吉隆, 駒沢 勉, 森下 健
    動脈硬化
    1984年 12 巻 3 号 703-711
    発行日: 1984/08/01
    公開日: 2011/09/21
    ジャーナル フリー
    1) Nine male rabbits 38 months old were concurrently loaded with
    3
    different treatments i.
    e
    ., N2 gas inhalation, norepinephrine in injection and cholesterol oral administration, and left coronary anterior descending branch (LCA
    5
    ) was observed histochemically and determined for smooth muscle cell, elastin, collagen, acid mucopolysaccharides and glycoproteien in comparison with
    8
    healthy normal rabbits of the same age.
    2) The histology of the indurative group presented obivious histo-lesional findings such as atrophy and necrosis of the smooth muscle cells (SMC), swelling and stratified rupture of the inner elastic membrane, loses in content of medial elastin (EL) and collagen (CL) and their transfer from the tunica externa, and compensatory increases in content of acid mucopolysaccharides (AMPS) and glycoprotein (GP).
    3
    ) The results of the determination made of these
    5
    constituents revealed that the healthy normal group and the indurative group showed 65.
    4
    ±
    7
    .
    9
    and 46.
    7
    ±
    7
    .
    5
    (p<0.001) of SMC,
    9
    .
    6
    ±0.
    88
    and 12.2±2.78 (p<0.05) of EL 25.
    7
    ±
    4
    .02 and 35.
    6
    ±
    3
    .
    86
    (p<0.001) of CL, 14.
    4
    ±1.
    7
    and 20.2±2.85 (p<0.001) of AMPS and
    22
    .
    8
    ±
    5
    .
    9
    and 31.
    6
    ±
    7
    .
    5
    %
    E
    of GP, respectively, the indurative group showed significantly less content of SMC and significantly more contents of EL, CL, AMPS and GP than the healthy normal group.
  • Takaaki ISHIZUKA, Yasunori YAOITA, Masao KIKUCHI
    Chemical and Pharmaceutical Bulletin
    1997年 45 巻 11 号 1756-1760
    発行日: 1997/11/15
    公開日: 2008/03/31
    ジャーナル フリー
    Four new sterols,
    ,
    -epoxy-(
    22
    E
    , 24R)-ergosta-
    8
    (14),
    22
    -diene-
    ,
    -diol (1), (
    22
    E
    , 24R)-ergosta-
    8
    ,
    22
    -diene-
    ,
    ,
    ,
    -tetrol (2), (
    22
    E
    , 24R)-ergosta-
    7
    ,
    9
    (11),
    22
    -triene-
    ,
    ,
    -triol (
    3
    ) and
    ,
    ,
    -trihydroxy-(
    22
    E
    , 24R)-ergost-
    22
    -en-
    7
    -one (
    4
    ), have been isolated from the fruit bodies of Grifola frondosa (FR.) S.
    F
    . GRAY (Polyporaceae)together with fourteen known ones (
    5
    -18), of which two (
    5
    and
    6
    ) are reported for the first time from a natural source. The structures of these compounds were elucidated on the basis of spectral data.
  • A.M. BRITTO,
    C
    . SAVVIDOU, M.J. GUNN, J.R. BOOKER
    土質工学会論文報告集
    1992年 32 巻 1 号 13-25
    発行日: 1992/03/15
    公開日: 2008/02/29
    ジャーナル フリー
    One method currently being considered for the disposal of high level radio-active waste is burial in the seabed. When a hot object is buried in soil, the temperature of the soil adjacent to the object is raised and there is transient heat flow away from the object. The rise in the temperature of the soil causes excess pore pressures to be generated and transient pore water diffusion also takes place. A finite element formulation of the coupled heat flow and consolidation problem is presented. The computer implementation of this formulation is found to compare favourably with analytical solutions based on the same physical principles.
  • Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori
    Biological and Pharmaceutical Bulletin
    2002年 25 巻 8 号 1040-1044
    発行日: 2002年
    公開日: 2002/08/01
    ジャーナル フリー
    We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC
    3
    T
    3
    -
    E
    1. Sixteen phosphate buffered saline (PBS),
    8
    boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC
    3
    T
    3
    -
    E
    1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
    22E
    ,24R)-ergosta-
    7
    ,
    22
    -diene-
    ,
    ,
    -triol (1). 1 induced ALP activities of MC
    3
    T
    3
    -
    E
    1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC
    3
    T
    3
    -
    E
    1 cells by 1, ergosterol (2), ergocalciferol (
    3
    ), cholesta-
    ,
    ,
    -triol (
    4
    ),
    7
    -dehydrocholesterol (
    5
    ) and cholecalciferol (
    6
    ) were tested. The enzyme activities of MC
    3
    T
    3
    -
    E
    1 cells were increased
    3
    .0-fold by 10 μM 1 and 2.
    4
    -fold by 10 μM
    4
    . However, 2,
    3
    ,
    5
    and
    6
    did not induce MC
    3
    T
    3
    -
    E
    1 cell ALP activity at 0.1—10 μM. These results suggested that the OH groups at
    C
    -
    5
    and/or
    C
    -
    6
    of 1 and
    4
    played an important role in their differentiation-inducing activities on MC
    3
    T
    3
    -
    E
    1 cells. Furthermore, 1 suppressed induction of MC
    3
    T
    3
    -
    E
    1 cell apoptosis by serum starvation.
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