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The Properties of 2112 keV Level in ¹¹⁶Sn

Yukichi Yamaguchi, Jian-zhi Runan(Gen), Teruaki Nagahara

Journal of the Physical Society of Japan
1975年 38 巻 4 号 911-916
発行日: 1975/04/15
公開日: 2007/06/01

DOI https://doi.org/10.1143/JPSJ.38.911

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The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the ^116mIn activity. Directional correlations are also measured for 818–1293 and 1097–1293 keV cascades. The M1-
E
2 mixing ratio δ, and the
E
0-
E
2 mixing ratio μ_k are obtained for 818.
7
keV
2₂
+→2₁⁺ transition to be δ=1.52_{−0.22
+0.26, and μ_k≤6.1×10^{−4
respectively. The E
2 branching ratio B
(E
2; 2₂
+}→0_g⁺): B
(E
2; 2₂
+→2₁⁺): B
(E
2; 2₂
+→0₁⁺) is determined to be 0.0158:1.0:5.86.
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EFFECTS OF SOIL PLUG ON BEHAVIOUR OF DRIVEN PIPE PILES

松本樹典, 武井正孝

土質工学会論文報告集
1991年 31 巻 2 号 14-34
発行日: 1991/06/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.31.2_14

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Stress wave theory is applied to open-ended pipe piles to clarify the effects of soil plug on the behaviour of piles during driving and static loading. Measured field data and various numerical models are reviewed ; methods are presented to calculate wave propagation in both the pile and the soil plug ; modelling is presented which takes into account the interaction between the soil plug and the pile ; also presented is simplified method to estimate the loadsettlement relation of the pipe pile in static loading. By correlating observed and calculated values in two analytical cases, the authors demonstrate that incorporation of the soil plug (modelled as a series of masses and springs) is required to correctly predict pile behaviour during driving and static loading.
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Interaction of Glycophorin with Lipid Bilayer Studied by Calorimetry, Densitometry, Static Light Scattering, and Electron Microscopy

Sen-fang Sui, Erich Sackmann

The Journal of Biochemistry
1992年 111 巻 1 号 129-138
発行日: 1992年
公開日: 2008/11/18

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In the first part of the present work the interaction of glycophorin with dimyristoylphosphatidylcholine (DMPC) is studied by freeze fracture electron microscopy, densitometry, calorimetry, and 90° static light scattering. An exothermic lipid/protein interaction energy of W_P=190 kJ•mol^-1 was found by application of the well known Van Laar relation for the displacement of the freezing point and the Gibbs-Duhem relationship. Secondly, the effects of Ca²⁺ on the lipid/protein interaction were studied. Following Ca²⁺ addition a remarkable decoupling of the interaction of the glycophorin head group with the bilayer surface was revealed by densitometry and gold-labeling electron microscopy. It is estimated that about 80% of lipid once disturbed by the adsorption of glycophorin head groups is decoupled after addition of Ca²⁺. Thirdly, the selective interaction of glycophorin with binary lipid mixtures was studied, including the mixtures of DMPC with dimyristoylphosphatidylserine (DMPS) and dilauroylphosphatidylcholine (DLPC), and the mixture of dipalmitoylphosphatidylcholine (DPPC) with DLPC.
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高脂血症の赤血球膜Vitamin
E
について

石岡達司, 樋口好美, 宮原潔, 出宮通孝, 三島康男, 深田耕史, 木畑正義

動脈硬化
1984年 12 巻 5 号 1103-1106
発行日: 1984/12/01
公開日: 2011/09/21

DOI https://doi.org/10.5551/jat1973.12.5_1103

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Some studies on Vitamin-
E
contents in red blood cells (RBC) have been reported by Kayden and others since 1972. But its clinical meanings are still unequivocal. The auther tried to detect the correlationship between serum lipids and RBC-Vitamin-
E
in hyperlipidemic patients. Vitamin-
E
in RBC were measured by micromethods using high pressure liquid chromatography (HPLC) with amperometric detector which was modified from Mino's methods. Result were as follows. RBC-Vitamin-
E
; 17.
91
±2.28 (ng/10 RBC) in control group.
22
.
8
±5.
8
in type. 21.
7
±
4
.
4
in type. 21.3±
4
.
4
in type. As above described, Vitamin-
E
in hyperlipidemic RBC is higher than controls and furthermore Vitamin-
E
in RBC were generally correlated positively to HDL-Cholesterol and to HDL-Vitamin-
E
. On the other hand, the statistical negative correlationship between RBC-Vitamin-
E
and atherogenic index (LDL-C/HDL-C) was revealed.
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熱力学諸量の測定とその結果を用いた化学熱力学計算によるNi-Mo-
B
およびNi-W-
B
3成分系状態図の決定

香山滉一郎, 森下政夫, 張国鋒

粉体および粉末冶金
2006年 53 巻 5 号 419-429
発行日: 2006年
公開日: 2006/12/19

DOI https://doi.org/10.2497/jjspm.53.419

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The phase diagrams of the Ni-Mo-
B
and Ni-W-
B
ternary systems in the region of less than 50mol%
B
were constructed by thermodynamic calculation, based on the data obtained by thermodynamic measurement of the related materials. We found three ternary eutectic points and three or two ternary peritecto-eutectic points as follows:
E₁
:L (1365K, 71.5mol%Ni-6.0mol%Mo-
22
.5mol%
B
)=(Ni)+
Ni₃B
+
NiMo₂B₂

E₂
:L (1355K, 62.5mol%Ni-2.5mol%Mo-30.5mol%
B
)=
Ni₃B
+
Ni₂B
+
NiMo₂B₂

E₃
:L (1445K, 42.0mol%Ni-30.6mol%Mo-10.3mol%
B
)=(Ni)+NiMo+
NiMo₂B₂

P₁:L (1812K, 34.9mol%Ni-42.3mol%Mo-
22
.
8
mol%
B
)+MoB=
Mo₂B
+
NiMo₂B₂

P₂:L (1633K, 42.3mol%Ni-40.
4
mol%Mo-17.3mol%
B
)+Mo=
Mo₂B
+
NiMo₂B₂

P₃:L (1812K, 53.5mol%Ni-33.
7
mol%Mo-12.
8
mol%
B
)+Mo=NiMo+
NiMo₂B₂

E₁
:L (1622K, 51.0mol%Ni-31.6mol%W-17.
4
mol%
B
)=(Ni)+W+
NiW₂B₂

E₂
:L (1260K, 71.0mol%Ni-
7
.0mol%W-
22
.0mol%
B
)=(Ni)+
Ni₃B
+
NiW₂B₂

E₃
:L (1291K, 65.
4
mol%Ni-
4
.
8
mol%W-29.
8
mol%
B
)=
Ni₂B
+
Ni₃B
+
NiW₂B₂

P₁:L (2115K, 23.
8
mol%Ni-43.1mol%W-33.1mol%
B
)+WB=
W₂B
+
NiW₂B₂

P₂:L (1657K, 48.9mol%Ni-33.1mol%W-18.0mol%
B
)+
W₂B
=W+
NiW₂B₂

The calculated phase diagrams are expected to be useful for the development of new Ni-based heat-, corrosion- or wear-resistance alloys.
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Cloning of Six Full-Length cDNAs Encoding Pig Cytochrome P450 Enzymes and Gene Expression of these Enzymes in the Liver and Kidney

Misaki Kojima, Takeya Morozumi

Journal of Health Science
2004年 50 巻 5 号 518-529
発行日: 2004年
公開日: 2004/10/01

DOI https://doi.org/10.1248/jhs.50.518

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Six full-length cDNAs encoding pig cytochrome P450 (CYP) enzymes, CYP1A1, CYP2A19, CYP2
B
22
, CYP2C33v
4
, CYP2C49, and CYP2
E
1, were isolated and sequenced. The cDNA sequences of pig CYP1A1, CYP2A19, CYP2
B
22
, CYP2C49, and CYP2
E
1 showed high similarity to human CYP1A1 (85.
4
%), CYP2A13 (88.6%),
CYP2B6
(
81
.1%), CYP2C18 (85.3%), and
CYP2E1
(82.5%), respectively, and pig
CYP2C33v4
cDNA showed high similarity to rat CYP2C23 (79.2%). Reverse transcription-polymerase chain reaction (RT-PCR) assays revealed hepatic gene expression of all these pig CYP enzymes: the order of expression was
CYP2C33v4
and
CYP2E1
> CYP2C49 > CYP1A1 and CYP2A19 >
CYP2B22
. In the kidney, the
CYP2C33v4
gene was expressed at the same level as in the liver, but the CYP1A1, CYP2A19, and
CYP2B22
genes were expressed at lower levels than in the liver. Little renal gene expression of CYP2C49 and CYP2
E
1 was observed. We revealed for the first time the full-length cDNA sequences encoding pig CYP1A1 and five CYP enzymes belonging to the CYP2 gene family, thus making it possible to examine the gene expression levels of these CYP enzymes in pig tissues by RT-PCR.

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Short-Step Synthesis of Plant Growth-Promoting Brassinosteroids

高津戸秀, 池川信夫

Chemical and Pharmaceutical Bulletin
1984年 32 巻 5 号 2001-2004
発行日: 1984/05/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.32.2001

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Brassinolide analogues, (
22
R, 23R, 24R)-2α, 3α,
22
, 23-tetrahydroxy-
B
-homo-
7
-oxa-5α-ergostan-6-one (24-epibrassinolide) (10) and (
22
S, 23S, 24R)-2α, 3α,
22
, 23-tetrahydroxy-
B
-homo-
7
-oxa-5α-ergostan-6-one (9), were synthesized from brassicasterol (3a) in five steps and with ca. 20% overall yield. The key steps are the direct formation of (
22
E
, 24R)-3α, 5-cyclo-5α-ergost-
22
-en-6-one (
4
) from brassicasterol mesylate (3
b
), the acid-catalyzed rearrangement of
4
to (
22
E
, 24R)-5α-ergosta-2,
22
-dien-6-one (6), and the Baeyer-Villiger oxidation of the tetrahydroxy 5α-ergostan-6-ones
7
and
8
.
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Deexcitation of the 931.1 keV
2₂
+-State of Cd¹⁵²

Yasuyuki Gono, Manabu Fujioka, Tamotsu Toriyama

Journal of the Physical Society of Japan
1970年 29 巻 2 号 255-258
発行日: 1970/08/05
公開日: 2007/06/01

DOI https://doi.org/10.1143/JPSJ.29.255

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The gamma-ray spectrum and the conversion-electron spectrum are measured in the decay of the Tb¹⁵² activity. The L-subshell electron lines of the 586.
7
keV
2₂
+→2₁⁺ transition are separated by the ion-free beta-ray spectrometer. The M1-
E
2 mixing ratio, δ², and the dimensionless ratio X of
E
0-
E
2 mixing of the 586.
7
keV transition are obtained to be δ²≤0.16 and 0.034≤X≤0.038, respectively. The
E
2 branching ratio
B
(
E
2;
2₂
+→0_g⁺):
B
(
E
2;
2₂
+→2₁⁺):
B
(
E
2;
2₂
+→0₁⁺) is determined to be 0.023 : 1.0 : 5.6.
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Stimulative Effects of (
22E
,24R)-Ergosta-
7
,
22
-diene-3β,5α,6β-triol from Fruiting Bodies of Tricholoma auratum, on a Mouse Osteoblastic Cell Line, MC3T3-
E
1

Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori

Biological and Pharmaceutical Bulletin
2002年 25 巻 8 号 1040-1044
発行日: 2002年
公開日: 2002/08/01

DOI https://doi.org/10.1248/bpb.25.1040

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We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC3T3-
E
1. Sixteen phosphate buffered saline (PBS),
8
boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC3T3-
E
1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
22E
,24R)-ergosta-
7
,
22
-diene-3β,5α,6β-triol (1). 1 induced ALP activities of MC3T3-
E
1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC3T3-
E
1 cells by 1, ergosterol (2), ergocalciferol (3), cholesta-3β,5α,6β-triol (
4
),
7
-dehydrocholesterol (5) and cholecalciferol (6) were tested. The enzyme activities of MC3T3-
E
1 cells were increased 3.0-fold by 10 μM 1 and 2.
4
-fold by 10 μM
4
. However, 2, 3, 5 and 6 did not induce MC3T3-
E
1 cell ALP activity at 0.1—10 μM. These results suggested that the OH groups at C-5 and/or C-6 of 1 and
4
played an important role in their differentiation-inducing activities on MC3T3-
E
1 cells. Furthermore, 1 suppressed induction of MC3T3-
E
1 cell apoptosis by serum starvation.
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Lifetime Measurements of Excited States in ⁶²Ni

Hajime Ohnuma, Jirohta Kasagi, Yuichi Iritani, Norio Kishida

Journal of the Physical Society of Japan
1978年 45 巻 4 号 1092-1098
発行日: 1978/10/15
公開日: 2007/05/29

DOI https://doi.org/10.1143/JPSJ.45.1092

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Gamma rays from the ⁵⁹Co(α, pγ)⁶²Ni reaction were observed in coincidence with protons at E_α=
8
MeV. Lifetimes of excited states in ⁶²Ni were determined by the Doppler-shift attenuation method. The
B
(
E
2) values obtained for the 2₁⁺ and
2₂
+ states are in good agreement with the shell-model calculations with e_eff=1.
7
, while
B
(
E
2, 4₁⁺→2₁⁺) is much larger and
B
(
E
2, 4₂⁺→2₁⁺) much smaller than the shell model values. Decay scheme of the states in ⁶²Ni up to
4
.16 MeV are also discussed.
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Role of Vitamins C and
E
in Regulating Antioxidant and Pro-Oxidant Markers in Preeclampsia

Mohd Suhail, Mohd Faizul Suhail, Hina Khan

Journal of Clinical Biochemistry and Nutrition
2008年 43 巻 3 号 210-220
発行日: 2008年
公開日: 2008/10/31

DOI https://doi.org/10.3164/jcbn.2008067

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We compared three groups of pregnant women: placebo with normotensive women, group A which included preeclamptics, and group
B
which comprised preeclamptics who were supplemented their diets with vitamins C and
E
. MDA increased from 6.
22
± 2.
8
(placebo) to
8
.48 ± 1.2 (A) and
8
.02 ± 1.
8
nmol/gHb (
B
). NO concentrations were enhanced from 19.3 ±
4
.2 (P) to 23.
8
± 6.
4
(A) and 24.1 ± 5.
4
μmol/L (
B
). GSH contents were decreased from 10.42 ± 2.
81
(P) to
8
.02 ± 2.92 (A) and 9.39 ± 1.02 μmol/g Hb (
B
), whereas GSSG concentrations increased from 0.98 ± 0.28 (P) to 1.24 ± 0.29 (A) and 1.08 ± 0.12 μmol/g Hb (
B
). SOD activity decreased 23% in A and 14% in
B
; GRx decreased 27% in A and 5.5% in
B
; GPx decreased 12% in A and 9.6% in
B
. Catalase activity, however, increased 27% in A and 29% in
B
as compared to control. Thus, we conclude that the use of vitamins C and
E
should be considered for the control of certain important biochemical indices during the development of preeclampsia; however, further studies are needed to develop methods for the prevention of preeclampsia in women at high risk.

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Prevalence and molecular characterization of extended-spectrum β-lactamase (ESBL) and plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli in dogs

Özkan ASLANTAŞ, Ebru Şebnem YILMAZ

Journal of Veterinary Medical Science
2017年 79 巻 6 号 1024-1030
発行日: 2017年
公開日: 2017/06/16
[早期公開] 公開日: 2017/04/27

DOI https://doi.org/10.1292/jvms.16-0432

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This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs for virulence genes and phylogenetic groups were also performed. Cefotaxime resistant
E
. coli isolates were detected in 95 (
22
.2%) of the swab samples. Sequencing analysis results showed occurrence of various β-lactamase genes: bla_CTX-M-15 (62), bla_{TEM-1b
(42), bla_CMY-2 (22
), bla_CTX-M-3 (16), bla_CTX-M-1 (15), bla_OXA-1 (9) and bla_SHV-12 (3) alone or in combination. The most frequently encountered phylogenetic group was group A₁ (35.8
%), followed by group D₂ (22
.1%), B
1 (15.8
%), D₁ (9.5%), A₀ (7
.4
%), B2₂
(5.3%) and B2₃
(4
.2%), respectively. PMQR genes, aac(6’)-Ib-cr, qnrS1 and qnrB10 were detected in 25.3, 10.5 and 1.1% of the isolates, respectively. While all isolates were susceptible to imipenem and amikacin, resistance rates to non-β-lactam antibiotics ranged from 20.0% for tobramycin to 56.8
% for tetracycline. The virulence genes were only detected in 34 (36.2%) of the isolates and this isolates carried single or various combination of virulence genes of iucD, papC, papE, f17a-A and eaeA. Four isolates were identified as human virulent pandemic CTX-M-15 producing E
. coli clone O25b
:ST131/B
2. To the best of our knowledge, this is the first study to show fecal carriage of ESBL/pAmpC type β-lactamase producing E
. coli isolates among dogs in Turkey.
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The effect of extended aging on the optical properties of different zirconia materials

Tariq F. Alghazzawi

Journal of Prosthodontic Research
2017年 61 巻 3 号 305-314
発行日: 2017年
公開日: 2017/09/12

DOI https://doi.org/10.1016/j.jpor.2016.11.002

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Purpose: The purpose of this study was to determine if the optical properties of zirconia and glass–ceramic (
e
.max) were affected by low-temperature degradation (aging).
Methods: Experiment samples were fabricated with seven zirconia brands (n=10): Zenostar, Zirlux, Katana, Bruxzir, DD-BioZX², DD-cubeX², NexxZr; and
e
.max were used as a control. This resulted in a total of 80 samples in the experiment. The L*, a* and
b
* were measured for each sample, and then the optical properties including translucency parameter (TP), contrast ratio (CR), and opalescence parameter (OP) were calculated. The samples were aged (20, 40, 60, 80, 100h), and the optical properties were calculated after each interval.
Results: Most zirconia brands had lower L*, higher a*, higher
b
* with increased aging, which visually corresponds to darker, redder, and more yellow. Aging also increased CR, lowered TP, and lowered OP.
e
.max was also affected by aging but still had the highest TP (23.9±2.
8
), L* (
81
.
7
±3.
4
), and lowest CR (0.41±0.05) compared to any zirconia. The Zenostar had the closest TP (24.1±0.
4
), and L* (90.2±0.5) values to
e
.max before aging. However, after 100h of aging, the DD-cubeX² was least effected and had the highest TP (
22
.2±0.6) and lowest CR (0.43±0.01) compared with other zirconia samples and highest OP (11.3±0.2) of all ceramic samples.
Conclusions: The optical properties of zirconia and
e
.max materials were affected by aging with the effects increasing with time. The magnitude of change was affected by seven brands of dental zirconia.

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GEOTECHNICAL RECONNAISSANCE STUDY ON DAMAGE CAUSED BY 2001 GUJARAT EARTHQUAKE, INDIA

東畑郁生, PRASAD S.K., 本多剛, CHANDRADHARA G.P.

地盤工学会論文報告集
2002年 42 巻 4 号 77-88
発行日: 2002/08/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf.42.4_77

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The Gujarat earthquake in India occurred in January, 2001, and caused significant damage in the province of Gujarat. The Japanese Geotechnical Society sent a small reconnaissance team to the damaged region after the quake. The present text presents the report from this activity. The major attention of the team was focused on geotechnical aspects of the damage which were related to earthfill dams and harbor land fills. It was found that a significant portion of damage was concentrated in fills resting on soft natural soils. Swedish weight soundings which were conducted at two places demonstrated the existence of such a soft subsoil. From this, it was concluded that amplification of earthquake shaking as well as the permanent deformation in the soft foundation soil induced such kinds of damage as subsidence, cracking, and lateral spreading in overlying artificial fills. For the better seismic resistance of those affected fills during future earthquakes, the improvement of soft subsoil seems essential.
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DYNAMIC RESPONSES OF FLEXIBLE RECTANGULAR FOUNDATIONS EMBEDDED INTO A VISCOELASTIC HALF-SPACE TO OBLIQUELY INCIDENT WAVES

蒋通, 栗林栄一

土質工学会論文報告集
1988年 28 巻 1 号 56-64
発行日: 1988/03/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.28.56

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The boundary element method expanded in frequency domains is presented to analyze the dynamic interaction between an embedded flexible rectangular foundation and soil with consideration of the obliquely incident waves. Numerical results describing the influence of the flexibility of the foundation on the dynamic responses of the foundation due to obliquely incident waves indicate that the flexibility of actual foundations can diminish the reduction of translation responses and increase the rotational responses in the high frequency range. These phenomena are more conspicuous as the embedment ratio is larger and the value of the wave velocity ratio of the soil and the foundation approaches to unity. When the high frequency components of the input ground motion are important and the basement has higher flexibility (for example ₂v_s/₁v_s >0.
4
), the analysis method which considers the basement as a rigid foundation may lead to unsafety estimations and the estimation of the flexibility of the foundation is necessary as analysing the effective input motion with consideration of the incident waves.
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地盤構造の急変する地域での表面波の振幅異常

山田善一, 野田茂

土質工学会論文報告集
1988年 28 巻 1 号 143-152
発行日: 1988/03/15
公開日: 2008/02/29

DOI https://doi.org/10.3208/sandf1972.28.143

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40 五味子の新dibenzocyclooctadiene型リグナンの構造と反応

田口平八郎, 池谷幸信, 吉岡一郎

天然有機化合物討論会講演要旨集
1979年 22 巻 40
発行日: 1979/09/20
公開日: 2017/08/18

DOI https://doi.org/10.24496/tennenyuki.22.0_299

会議録・要旨集フリー

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Three new dibenzocyclooctadiene lignans, epigomisin O(1), gomisin
E
(
7
) and angeloylgomisin Q(26), were isolated from the fruits of Schizandra chinensis BAILL.(Schizandraceae), which are used as an antitussive and a tonic under the names of "Hoku-gomisi" in Japan and "Wu-wei-zi" in China. 1) The structure of epigomisin O(1) was elucidated by correlation with known lignans, gomisins O(2) and N(
4
). 2) Oxidation of
4
with KMnO_
4
in a mixture of 2% NaOH and pyridine gave compounds 3 and 5. Further oxidation of 3 with KMnO_
4
gave 5. Reduction of 5 with NaBH_
4
afforded deangeloylgomisin
B
(6). The structure of gomisin
E
(
7
) was elucidated by the same reaction to correlate with a known lignan, gomisin D(
8
). 3) The cleavage of the methylenedioxy group on the aromatic ring with Pb(OAc)_
4
in dry benzene into diphenol was studied(19-
22
→19
b
-
22
b
). The structure of angeloylgomisin Q(26) was elucidated by the use of the above reaction to correlate with 6.
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虚血性心臟病におけるコレステロール負荷時の血清リポ蛋白変動(第2報)

―特にアポ蛋白Eの変化について―

本間康彦, 三神美和, 佐藤美智子, 石原仁一, 吉川広, 木下栄治, 田川隆介, 星合充基, 古屋秀夫, 井出満, 田辺晃久, 玉地寛光, 兼本成斌, 友田春夫, 中谷矩章, 五島雄一郎

動脈硬化
1984年 12 巻 3 号 599-603
発行日: 1984/08/01
公開日: 2011/09/21

DOI https://doi.org/10.5551/jat1973.12.3_599

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Seven hundred fifty mg of cholesterol were fed daily to 32 patients of the ischemic heart disease (IHD) for 2 weeks. Cholesterol amounts in VLDL, LDL, HDL, HDL₂ and HDL₃ were estimated on the 0th,
7
th and 14th days of cholesterol load. Plasma apoprotein A-I, A-II,
B
, C-II,
E
levels were also measured in 16 from 32 IHD subjects. Apoprotein levels were estimated by a method of single radial immunodiffusion (SRID). Before cholesterol administration, cholesterol amounts in VLDL, LDL, HDL, HDL₂ and HDL₃ were 15.9±
7
.5mg/dl (mean±SD), 150.9±58.1mg/dl 43.
8
±9.6mg/dl, 16.
4
±5.
8
mg/dl and 24.9±6.3mg/dl respectively. Plasma apoprotein A-I, A-II,
B
, C-II and
E
levels were
81
.
7
±
22
.0 mg/dl, 15.1±5.
4
mg/dl, 93.
7
±36.0mg/dl, 3.83±1.00mg/dl and
4
.29±1.36mg/dl respectively. After 2 weeks' cholesterol feeding, all plasma lipoprotein cholesterol and apoprotein levels did not change significantly. Correlation coefficients between plasma apoprotein and lipoprotein cholesterol levels were calculated. Apoprotein A-I and A-II correlated with HDL-C (r=0.348), HDL₂-C (r=0.612) and HDL₃ (r=0.569). Apoprotein
B
correlated with total cholesterol (TC) (r=0.610), VLDL-C (r=0.341), LDL-C (r=0.726), HDL-C (r=0.432) and HDL₂-C (r=0.465). Apoprotein C-II correlated with TC (r=0.765), TG (r=0.679), VLDL-C (r=0.651), LDL-C (r=0.461) and HDL₂-C (r=0.326). Apoprotein
E
correlated with TC (r=0.580), TG (r=0.575) and VLDL-C (r=0.666). Interapoprotein's correlations were also calculated. Apoprotein A-I correlated with apoprotein A-II (r=0.468). Apoprotein
B
correlated with apoprotein C-II (r=0.393). Apoprotein C-II correlated with apoprotein
B
(r=0.393) and
E
(r=0.549). Apoprotein
E
only correlated with apoprotein C-II (r=0.549).
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Photochemical Reaction of Ergosta-
4
, 6,
8
(14),
22
-tetraen-3-one

Nobutoshi TANAKA, Ken-ichi HOSOI, Daizo TANAKA, Mimei TAKAHASHI

Chemical and Pharmaceutical Bulletin
1996年 44 巻 4 号 843-846
発行日: 1996/04/15
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.44.843

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Chemical properties of ergosta-
4
, 6,
8
(14),
22
-tetraen-3-one (1) were investigated. Though 1 is rather stable to acids or bases, it reacts easily with two moleculres of oxygen on irradiation with UV light to give 6α, 9α-epidioxy-14α-hydroperoxyergosta-
4
,
7
,
22
-trien-3-one (2), which is transformed successively to 6α,
7α
;
8α
, 9α-diepoxy-14α-hydroperoxyergosta-
4
,
22
-dien-3-one (3) and 14α-hydroperoxy-9α-hydroxyergosta-
4
,
7
,
22
-triene-3, 6-dione (
4
) under these reaction conditions.
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Prolonged T-peak to T-end Interval Predicts Implantable Cardioverter Defibrillator Therapy in Patients With Cardiac Sarcoidosis

Shohei Kataoka, Daigo Yagishita, Kyoichiro Yazaki, Miwa Kanai, Shun Hasegawa, Morio Shoda, Junichi Yamaguchi

Circulation Journal
2023年 87 巻 8 号 1058-1067
発行日: 2023/07/25
公開日: 2023/07/25
[早期公開] 公開日: 2023/06/21

DOI https://doi.org/10.1253/circj.CJ-23-0058

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Background: The association between the T-peak to T-end interval (Tp-
e
) and ventricular arrhythmia (VA) events in cardiac sarcoidosis (CS) is unknown. The purpose of this study was to investigate whether Tp-
e
was associated with VA events in CS patients with implantable cardioverter defibrillators (ICDs) or cardiac resynchronization therapy defibrillators (CRT-Ds).
Methods and Results: We retrospectively studied 50 patients (16 men; mean [±SD] age 56.3±10.5 years) with CS and ICD/CRT-D. The maximum Tp-
e
in the precordial leads recorded by a 12-lead electrocardiogram after ICD/CRT-D implantation was evaluated. The clinical endpoint was defined as appropriate ICD therapy. During a median follow-up period of 85.0 months,
22
patients underwent appropriate therapy and 10 patients died. Kaplan-Meier analysis revealed that the probability of the clinical endpoint was 28.3% at 2 years and 35.3% at
4
years. The optimal cut-off value of the Tp-
e
for the prediction of the clinical endpoint was
91
ms, with a sensitivity of 72.
7
% and a specificity of 87.0% (area under the curve=0.
81
). Multivariate Cox regression analysis showed that Tp-
e
≥
91
ms (hazard ratio [HR] 5.10; 95% confidence interval [CI] 1.99–13.1; P<0.001) and a histological diagnosis of CS (HR 3.84; 95% CI 1.28–11.5; P=0.016) were significantly associated with the clinical endpoint.
Conclusions: Tp-
e
≥
91
ms was a significant predictor of VA events in patients with CS and ICD/CRT-D.

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