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右房室弁の形態学的検索

その所属腱索および乳頭筋について

島田博

日本医科大学雑誌
1981年 48 巻 6 号 779-789
発行日: 1981/12/15
公開日: 2010/10/14

DOI https://doi.org/10.1272/jnms1923.48.779

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Although there have been numerous articles concerning the anatomy of the atrioventricular valve in man, only a few publications have recorded the relationship between the chordae tendineae and the papillary muscles. The purpose of this paper is to study the relationship among the shape and size of the atrioventricular valve, the chordae tendineae and the papillary muscles. 50 subjects, as listed in Table 1, were analyzed by the Taniya-Hashimoto Method.
The results obtained were as follows:
1) The right atrioventricular valve was classified into two types: 33 cases (66%) of three irregularly shaped cusps, i.
e
. type I, and 17 cases (34%) of four or five cusps, i.
e
. type II.
2
) The average circumference of the right atrioventricular orifice (ostium atrioventriculare dextrum) was 11.
96
cm (
9
.63.15.06cm) in type I and 12.19cm (
9
.52.15.
22
cm) in type H. There existed no significant difference in the circumference of the atrioventricular orifice between type I and II.
3) The average length of the cusp-fundus (the length of the fixed margin of the cusp) was as follows:
type I: anterior cusp…………4.13cm (
2
.03-6.
96
cm)
posterior cusp…………3.62cm (1.21-
5
.44cm)
septalcusp……………4.21cm (3.11-6.08cm)
type II: anterior cusp…………4.10cm (
2
.68-
5
.42cm)
posterior cusp…………3.67cm (0.
94
-
5
.70cm)
septal cusp……………4.43cm (
2
.
96
-6.53cm)
4) The average width of the cusp (the maximum distance between the apex and the fundus of the cusp) was as follows:
type I: anterior cusp…………1.86cm (1.26-
2
.29cm)
posterior cusp…………1.62cm (0.62-
2
.
94
cm)
septal cusp……………1.76cm (1.15-
2
.72 cm)
type II: anterior cusp…………1.92cm (1.40-
2
.34cm)
posterior cusp…………1.72cm (0.
94
-
2
.42cm)
septal cusp……………1.84cm (1.14-
2
.53cm)
The length or width of the cusp in type I was similar to that in type II.
5
) The papillary muscles consisted of five groups, which were named the anterior, postlateral, postmedial, postseptal and septal muscles. The average number of the papillary muscles per right ventricle was
5
.
7
(
2
.0.
9
.0). The chordae tendineae from the anterior papillarymuscles were attached to the anterior and posterior cusps and those from the postlateral and postmedial muscles were attached to the posterior and septal cusps. The chordae tendineae from the postseptal muscles were linked only to the septal cusp and those from the septal muscles were connected to the septal and anterior cusps.
6) The average number of the stems of the chordae tendineae from the papillary muscles were as follows:
From the anterior papillary muscles………
7
.
2
(
2
.0-14.0)
the postlateral papillary muscles……3.
5
(1.0-
8
.0)
the postmedial papillary muscles……4.0 (1.0-
8
.0) the postseptal papillary muscles……4.
5
(1.0-13.0) the septal papillary muscles………
5
.
7
(
2
.0-12.0)
The average n umber of the stems of the chordae tendineae per right ventricle was 24.4 (16.0-35.0).
7
) The tip of the chordae tendineae are attached to the fixed margin of the valve cusp, i.
e
. type A, to the ventricular surface, i.
e
. type B and to the free margin, i.
e
. type C. The average number of them were 23.4 (14.0-32.0) in type A, 19.
2
(4.0-37.0) in type B and 68.1 (31.0-105.0) in type C. The average number of the apexes of the chordae tendineae per right ventricle was 110.
7
(53.0-166.0).
8
) The average number of the chordae tendineae for the anterior cusp was 34.
9
(12.0-64.0), for the posterior cusp 30.
5
(
5
.0-65.0) and for the septal cusp 45.3 (23.0-68.0).
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Angiographic Determination of Left and Right Ventricular Volumes and Left Ventricular Mass in Normal Infants and Children

TOMOHARU AKIBA, MITSURU NAKASATO, SATOSHI SATO, ATSUKO KIKAI

The Tohoku Journal of Experimental Medicine
1995年 177 巻 2 号 153-160
発行日: 1995年
公開日: 2006/08/31

DOI https://doi.org/10.1620/tjem.177.153

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AKIBA, T., NAKASATO, M., SATO, S. and KIKAI, A. Angiographic Determination of Left and Right Ventricular Volumes and Left Ventricular Mass in Normal Infants and Children. Tohoku J. Exp. Med., 1995, 177 (
2
), 153-160-Left and right ventricular (LV and RV) volumes and LV mass were assessed by angiography in 63 infants and children without major cardiovascular abnormalities. LV and RV end-diastolic volumes (EDV) were excellently expressed as a function of body surface area (BSA) with an exponential equation: LVEDV=83.
7
(BSA)^1.29ml (r=0.
96
, p<0.001), RVEDV=87.
9
(BSA)^1.29ml (r=0.
94
, p<0.001). LV ejection fraction (
E

F
) averaged 64±6 ( mean±standard deviation) %, and RVEF 56±
5
%, each of which was independent of BSA. LV mass was well expressed as a function of BSA with an exponential equation: LV mass=75.4 (BSA)^{1.22g
(r=0.86, p< 0.001). LV mass/LVEDV was constant, and averaged 0.96
±0.22g/ml. Thus, the values of LVEDV, RVEDV, and LV mass in infants and children with various heart diseases may be estimated with reasonable accuracy as a percentage of normal values predicted from their BSA by using the above-proposed exponential equations. The normal values of LVEF, RVEF and LV mass/LVEDV themselves can be compared with these parameters in pediatric patients with heart diseases because of their independence of BSA.-ventricular volumes; ejection fraction; left ventricular mass; angiography; normal infants and children
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市販鶏肉におけるカンピロバクターの定量検査と分離菌株の血清型

小野一晃, 斎藤志保子, 川森文彦, 後藤公吉, 重茂克彦, 品川邦汎

日本獣医師会雑誌
2004年 57 巻 9 号 595-598
発行日: 2004/09/20
公開日: 2011/06/17

DOI https://doi.org/10.12935/jvma1951.57.595

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2000年
7
月から
9
月にかけて, 4県 (静岡, 埼玉, 秋田および新潟) で採集した市販鶏肉 (むね肉, もも肉および手羽先) 計128検体におけるカンピロバクター (Campylobacter jejnni/coli) の汚染率は75.0%(
96
/128) であり, 汚染菌数 (MPN法) は陽性
96
検体中92検体 (95.
8
%) において10³cfu/100g以下であった.また, 分離されたカンピロバクター-192株はC.jejuni (182株,
94
.
8
%) およびC.coli (10株
5
.
2
%) に同定され, Penner法による血清型刷では, B群
22
株 (11.
5
%),
F
群16株 (
8
.3%), C群15株 (
7
.
8
%) などで, 型別不能株は47株 (24.
5
%) であった.
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23pSM-6 Isoscalar and Isotensor π-π Scattering Lengths from K^+_<π3> Decays

T BAKER, C. RANGACHARYULU

日本物理学会講演概要集
1999年 54.2.1 巻 23pSM-6
発行日: 1999/09/13
公開日: 2018/03/04

DOI https://doi.org/10.11316/jpsgaiyo.54.2.1.0_16_3

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Potassic-ferropargasite, a new member of the amphibole group, from Kabutoichiba, Mie Prefecture, central Japan

Yasuyuki BANNO, Ritsuro MIYAWAKI, Satoshi MATSUBARA, Eriko SATO, Izumi NAKAI, Gen-ichiro MATSUO, Shigeo YAMADA

Journal of Mineralogical and Petrological Sciences
2009年 104 巻 6 号 374-382
発行日: 2009年
公開日: 2010/01/06
[早期公開] 公開日: 2009/11/07

DOI https://doi.org/10.2465/jmps.090122

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Potassic-ferropargasite, ideally
KCa₂
(Fe₄²⁺Al)
Si₆Al₂O₂₂
(OH)_{2
, is a new member of the amphibole group occurring in a schistose calcareous hornfels from Kabutoichiba, Kameyama, Mie Prefecture, central Japan. The amphibole occurs as black subhedral to anhedral crystals, up to about 700 μm long, associated with calcite, biotite, K-feldspar, plagioclase, scapolite, chlorite and titanite. Potassic-ferropargasite is optically biaxial negative with α = 1.680(2
), β = 1.690 (calc.), γ = 1.698(2
) and 2V
= 80-90°. The mineral is monoclinic, space group C2
/m, with refined unit-cell parameters a = 9
.937(5
), b = 18.108(5
), c = 5
.335(4) Å, β = 105.30(3)°, V = 926.0(9
) Å³, Z = 2
. The three strongest lines in the X-ray powder-diffraction pattern [d in Å (I) hkl] are 2
.72 (100) 151, 8
.48 (81) 110 and 2
.61 (59) 061. Electron-microprobe gave SiO₂
38.08, TiO₂
1.92, Al₂O₃
15.12, Cr₂O₃
0.44, FeO 19.96
, MnO 0.22
, MgO 6.22
, CaO 11.73, Na₂O
1.57, K₂O
2
.74, F
0.13, Cl not detected, O = F
+ Cl -0.05, total 98.08 wt%, corresponding to (K_0.54Na_0.42)_{Σ0.96
(Ca_1.95Na_0.05)_{Σ2.00
(Fe²
+_{2.59Mg_1.44Al_0.67Ti_0.22Cr_0.05Mn_0.03
)_{Σ5.00
(Si_5.91Al_2.09
)_{Σ8.00O₂₂
(OH_1.94F_0.06
)_{Σ2.00
on the basis of O = 23, assuming OH + F
+ Cl = 2
. The crystal structure of the clinoamphibole type was refined to an R of 6.5%.
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抗生物質の生体内動態に関する基礎的研究

第1編血清蛋白との結合について

橋本孝夫

CHEMOTHERAPY
1973年 21 巻 1 号 38-44
発行日: 1973/01/25
公開日: 2011/03/08

DOI https://doi.org/10.11250/chemotherapy1953.21.38

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The binding of penicillin G and other 29 antibiotics to the bovine plasma proteins, a part of the pharmacokinetics of antibiotics, was investigated by the ultrafiltrating technique at 4°C.
As the rates of the binding, inactivation, recovery and binding activity, following values were obtained in order : 64.
9
to 82.
7
%, 11.
96
to 56. 85%,
7
. 77 to 25. 75% and
8
.
9
to 34. 11% in penicillin antibiotics; 0 to 61. 4%, 0 to 10. 66%, 0. 49 to 12.
8
% and 14. 91 to 41. 72% in glycoside antibiotics; 91. 0 to 99.
9
%, 16. 0 to 46. 19%, 44. 98 to 71. 01% and 4. 33 to 21. 06% in tetracycline antibiotics; 55.
22
to
94
. 1%,
5
. 37 to 57. 36%, 1. 32 to 31.
5
% and
9
. 66 to 40. 65% in macrolide antibiotics; and 72. 6 to 95. 68%, 14. 34 to 51. 85%,
8
. 19 to 30. 12%, and 17. 28 to 41. 54% in chloramphenicol antibiotics, respectively.
Optimum pH of the binding of antibiotics to the plasma proteins was in the range
5
. 0 to
8
. 0, i.
e
.
8
. 0 in penicillin antibiotics,
5
. 0 in glycoside antibiotics,
7
. 0 to
8
. 0 in tetracycline antibiotics, 6. 0 to
7
. 0 in macrolide antibiotics, and
7
. 0 to
8
. 0 in chloramphenicol antibiotics, respectively.
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Formation by impact of some porphyritic rocks on the asteroid 4 Vesta

*Buchanan Paul

日本鉱物学会年会講演要旨集
2003年 2003 巻 C-41
発行日: 2003年
公開日: 2004/07/26

DOI https://doi.org/10.14824/kobutsu.2003.0.155.0

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Clast Q from the polymict eucrite EET 87509 is a fragment of porphyritic rock containing euhedral, skeletal pyroxene phenocrysts (0.
2
-1.
5
mm in size) in a fine-grained mesostasis predominantly composed of pyroxene, plagioclase, and a silica mineral. Phenocrysts have magnesian cores (
Wo₂En₇₂
), which are zoned to more Fe- and Ca-rich margins (Wo₁₄En₅₄) and rimmed by a narrow overgrowth of augite (Wo₃₂En₃₉). Pyroxene and feldspar laths in the mesostasis are small (up to 3x100 μm in size) and form sub-parallel aggregates, which radiate from phenocryst edges. Texture of this clast is strikingly similar to clast rho from the howardite Kapoeta [1].
　Bulk composition of clast Q was determined by INAA and modal recombination. Abundances of
Al₂O₃
for clasts Q (
9
.
94
wt. %) and rho (
9
.88 wt. %) [1] are significantly lower than those of the main group eucrites (
e
.g., Juvinas; 13.1 wt. %) [
2
], but are more similar to those of the howardites Malvern (
9
.
96
wt. %) [3] and EET 87513 (
8
.4 wt. %) [4]. Abundances of Ni (260 ppm) and Co (55.4 ppm) for clast Q [see also
5
] are much higher than those of Juvinas (4 ppm and 4.
7
ppm, respectively) [
2
], but are comparable to those of the howardites Malvern (274 ppm) [3] and EET 87513 (273 ppm) [4].
　Dymek et al. [1] interpreted clast rho as a magnesian volcanic rock. However, the
Al₂O₃
contents of clasts Q and rho are more similar to those of howardites compared to those of main group eucrites. Abundances of Ni and Co for clast Q also are more similar to those of some howardites that may contain components of other types of meteorites [
e
.g., 4]. Recently, Koizumi et al. [6] experimentally produced a similar porphyritic texture by linear cooling of
0.5^oC
/hr of a basaltic liquid. These data suggest that clast Q (and, perhaps, clast rho) may represent impact melt that formed from a howardite regolith with a small component of material derived from an impactor and experienced a moderate rate of cooling.
References: [1] Dymek R.
F
. et al. (1976) GCA 40, 1115-1130. [
2
] Kitts K. and Lodders K. (1998) Meteor. Planet. Sci. 33, A197-A213. [3] McCarthy T. S. et al. (1972) EPSL 15, 86-93. [4] Buchanan P. C. and Mittlefehldt D. W. (2003) AMR 16, 128-151. [
5
] Mittlefehldt D. and Lindstrom M. (1991) LPSC
22
, 901-902. [6] Koizumi
E
. et al. (2003) abstracts, Meteoritical Soc., #5175.
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VALLET, G. et VILLARD,
F
., Megara Hyblaea, 4. Le Temple du IV^
e
Siecle,
2
vols, Texte pp.76, Planches
96
, Paris,
E
. de Boccard, 1966

村田数之亮

西洋古典学研究
1968年 16 巻 140-143
発行日: 1968/03/30
公開日: 2017/05/23

DOI https://doi.org/10.20578/jclst.16.0_140

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(
22E
, 24S)
5α
-Stigmasta-3,
22
-dien-6-one: An Intermediate of the Isomerization of (
22E
, 24S)-3α,
5
-Cyclo-
5α
-stigmast-
22
-en-6-one into (
22E
, 24S)-
5α
-Stigmasta-
2
,
22
-dien-6-one

Suguru TAKATSUTO, Kiyomi KOBAYASHI, Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE

Agricultural and Biological Chemistry
1988年 52 巻 12 号 3217-3218
発行日: 1988年
公開日: 2006/04/05

DOI https://doi.org/10.1271/bbb1961.52.3217

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Sterol Constituents from the Fruit Bodies of Grifola frondosa (FR.) S.
F
. Gray

Takaaki ISHIZUKA, Yasunori YAOITA, Masao KIKUCHI

Chemical and Pharmaceutical Bulletin
1997年 45 巻 11 号 1756-1760
発行日: 1997/11/15
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.45.1756

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Four new sterols,
5α
, 6α-epoxy-(
22
E
, 24R)-ergosta-
8
(14),
22
-diene-3β,
7β
-diol (1), (
22
E
, 24R)-ergosta-
8
,
22
-diene-3β,
5α
, 6β,
7α
-tetrol (
2
), (
22
E
, 24R)-ergosta-
7
,
9
(11),
22
-triene-3β,
5α
, 6β-triol (3) and 3β,
5α
, 6β-trihydroxy-(
22
E
, 24R)-ergost-
22
-en-
7
-one (4), have been isolated from the fruit bodies of Grifola frondosa (FR.) S.
F
. GRAY (Polyporaceae)together with fourteen known ones (
5
-18), of which two (
5
and 6) are reported for the first time from a natural source. The structures of these compounds were elucidated on the basis of spectral data.
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Purines. L. Synthesis and Antileukemic Activity of the Antibiotic Guanine
7
-Oxide and Its
9
-Substituted Derivatives

小川和男, 西井正廣, 稲垣甚一郎, 野原富士夫, 斎藤徹, 板谷泰助, 藤井澄三

Chemical and Pharmaceutical Bulletin
1992年 40 巻 2 号 343-350
発行日: 1992/02/25
公開日: 2008/03/31

DOI https://doi.org/10.1248/cpb.40.343

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A full account is given of the first chemical synthesis of the antitumor antibiotic guanine
7
-oxide (
5
) and its
9
-substituted derivatives (24a-k and 26). Coupling of appropriate primary amines (17a-
e
, g-k) with phanecyl bromide (16) produced, after treatment with HCl, the corresponding N-substituted phenacylamine hydrochlorides (18a-
e
, g-k). A similar phenacylation of 4-amino-1-butanol (21) failed to give the desired compound 18
f
, so that 21 was heated with
2
-bromomethyl-
2
-phenyl-1, 3-dioxolane (20) at 150-155°C for 3h to furnish, after treatment with HCl, the amino ketal hydrochloride
22
in 40% yield. Deketalization of
22
with hot
2
N aqueous HCl afforded 18
f
in
96
% yield. Condensations of the free bases, generated in situ from the hydrochlorides 18a-l and 1N aqueous NaOH, with the chloropyrimidinone 6 were effected in aqueous EtOH at the boiling point for 20 min or at 25-30°C for 3-24h, giving the 6-phenacylamino-4-pyrimidinones 19a-l in 54-90% yields. On treatment with
2
N aqueous NaOH at room temperature for 10-60 min, the nitropyrimidinones 19a-k cyclized to provide the
9
-substituted guanine
7
-oxides 24a-k in 61-98% yields. A similar alkali-treatment of 19l failed to yield guanine
7
-oxide (
5
). However, removal of the
9
-(arylmethyl) group from 24i-k was effected with conc,
H₂SO₄
at room temperature for 1-3h in the presence of toluene, producing the target N-oxide
5
in 56-89% yields. In the in vitro bioassay of antileukemic activity against murine L5178Y cells, none of the
9
-substituted guanine
7
-oxides (24a-k and 26) was more effective than the parent, natural N-oxide
5
. Within this series, however, the benzyl analogues 24g-k with or without alkoxy functions were more cytotoxic, with IC₅₀'s of 13.0-48.0μg/ml, than the alkyl analogues 24a-
f
.
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学会員の喫煙状況と受動喫煙対策に関するアンケート調査 (第
2
報)

長尾徹, 河奈裕正, 柴原孝彦, 依田哲也, 嶋田淳, 楠川仁悟, 石垣佳希, 石橋美樹, 上田整

日本口腔外科学会雑誌
2019年 65 巻 10 号 651-660
発行日: 2019/10/20
公開日: 2019/12/20

DOI https://doi.org/10.5794/jjoms.65.651

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The Committee for Tobacco-Free Society of the Public Interest Incorporated Association for the Japanese Society of Oral and Maxillofacial Surgeons (JSOMS) performed a web questionnaire survey on smoking habits as well as tobacco-free policies among 7189 eligible members who had registered their
e
-mail addresses with the society in September 2018.
　Among all eligible members, 1877 provided valid responses (26.1%; male 78%, female
22
%). The prevalence of current smokers, ex-smokers, and never smokers was
7
.
2
% (male
8
.
5
%, female
2
.
2
%), 33.3% (male 40.0%, female
9
.3%), and 59.
5
% (male 51.
5
%, female 88.
5
%), respectively. The smoking rate was the highest in the 40s (
8
.6%) age group, followed by the 30s (
7
.
8
%), 20s (
7
.1%), and 50s (6.0%) age groups. The smoking rate was the highest among members who worked in private clinics (
9
.3%), followed by those who worked in dental teaching hospitals (
8
.1%), general hospitals (6.
7
%), and medical teaching hospitals (4.3%). The rate of asking patients about their smoking status regularly was the highest among members who worked in medical teaching hospitals (70%), followed by those who worked in private clinics (63%), dental teaching hospitals (62%), and general hospitals (56%). As for passive smoking measures,
96
% of members responded that there should be a smoke-free policy in their hospitals/clinics.
　Overall, the smoking rate of JSOMS members has declined by 3.3% points since the last survey in 2007 (10.
5
%). The tobacco-free policy should be further strengthened for all society members with respect to tobacco secession advice and passive smoking measures.

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A New Short-Lived Isomer in ¹¹⁴Sb

Carmen Gil, Kusuo Nishiyama, Toru Nomura, Toshimitsu Yamazaki, Kazumasa Miyano

Journal of the Physical Society of Japan
1973年 34 巻 4 号 874-879
発行日: 1973/04/05
公開日: 2007/06/01

DOI https://doi.org/10.1143/JPSJ.34.874

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A new short-lived isomer in ¹¹⁴Sb was found by using the technique of the in-beam gamma spectroscopy. Two new gamma rays at energies of
96
keV and 326 keV, decaying with a half-life of 275±20 μ sec, were found. A ratio of the intensities of the 326 keV gamma ray to that of the
96
keV gamma ray was obtained to be 1.0:0.34. The character of the 326 keV gamma ray was deduced to be an
E
3 transition and was found to be enhanced 6.
9
times than the single particle estimate. The
96
keV transition was concluded to be an
E
2
transition. A decay sequence of
8
−−326 keV (
E
3)→
5
+−
96
keV (
E
2
)→3⁺ (ground state of ¹¹⁴Sb) may be proposed. The observed enhancement of the
E
3 transition is explained in terms of a mixture of the
E
3 core polarization.
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北海道中部・南東部におけるアオジとクロジの繁殖期の生息状況

藤巻裕蔵

森林野生動物研究会誌
2011年 36 巻 9-14
発行日: 2011/03/30
公開日: 2017/10/03

DOI https://doi.org/10.18987/jjwrs.36.0_9

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1976〜2010年の4月下旬〜6月下旬(高標高地では
7
月下旬)に北海道中部・南東部の844区画(4.
5
km×
5
km),調査路952か所でアオジEmberiza spodocephalaとクロジ
E
.variabilisの生息状況を調べた.アオジが出現したのはそれぞれ811区画(
96
%),898か所(
94
%),クロジが出現したのは58区画(
7
%),118か所(12%)であった.アオジの生息環境別の出現率はハイマツ林で46%,常緑針葉樹林で100%,針広混交林で95%,落葉広葉樹林で98%,カラマツ人工林で100%,農耕地・林で99%,農耕地で
96
%,住宅地で35%であった.クロジの出現率はそれぞれの生息環境で
9
,20,59,12,0,0,0,0%であった.標高別の出現率は,アオジでは200m以下と201〜400mで
94
%,401〜600mで97%,601〜800mで
96
%,801m以上で69%,クロジではそれぞれの生息環境で
8
,21,17,48,31%であった.調査路
2
km当たりの平均観察個体数は,アオジではハイマツ林で0.
5
±1.0(平均値±標準偏差),常緑針葉樹林で
5
.
5
±
2
.6,針広混交林で
5
.3±3.3,落葉広葉樹林で6.3±4.
9
,カラマツ人工林で10.
2
±3.
9
,農耕地・林6.
9
±
5
.
2
,農耕地4.
8
±4.
5
,住宅地0.6±1.3.クロジではハイマツ林で0.1±1.0,常緑針葉樹林と針広混交林で0.3±0.
7
,落葉広葉樹林で0.3±0.
7
であった.
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An Efficient Preparation of (
22E
, 24S)-
5α
-Stigmasta-
2
,
22
-dien-6-one from (
22E
, 24S)-3α,
5
-Cyclo-
5α
-stigmast-
22
-en-6-one

Tsuyoshi WATANABE, Hiroki KURIYAMA, Tokuo FURUSE, Kiyomi KOBAYASHI, Suguru TAKATSUTO

Agricultural and Biological Chemistry
1988年 52 巻 8 号 2117-2118
発行日: 1988年
公開日: 2006/04/05

DOI https://doi.org/10.1271/bbb1961.52.2117

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小児患者の咬合力に関する研究

(1) 健全歯と充填処置歯の比較

土屋友幸, 高橋淳, 渡辺直彦, 鬼頭秀明, 井上三枝, 磯村文質, 黒須一夫

小児歯科学雑誌
1996年 34 巻 5 号 1157-1163
発行日: 1996/12/25
公開日: 2013/01/18

DOI https://doi.org/10.11411/jspd1963.34.5_1157

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本研究は,齲蝕に罹患していない小児と,軽度の齲蝕に罹患した小児の咬合力を比較検討するとともに,齲蝕に罹患した群の歯冠修復後の咬合力を検索することを目的として行った。被験者は,3歳から6歳の健全群の男児20名,女児18名の計38名と充填処置群の男児30名,女児28名の計58名,総計
96
名である。咬合力の測定は,咬合力計(日本光電社製:MPM-3000)を使用した。結果を要約すると,以下のようであった。健全群の咬合力は,右側第二乳臼歯で20.l±1.
9
kg,左側第二乳臼歯で19.
5
±
2
.4kg,右側第一乳臼歯で18.
9
±
2
.4kg,左側第一乳臼歯で18.3±
2
.
8
kgであり,第二乳臼歯部の方がやや高い値を示した。充填群の咬合力は,右側第二乳臼歯で処置前14.6±3.
7
kg,処置後18.
8
±
2
.
5
kgであった。左側第二乳臼歯は処置前14.
7
±35kg,処置後18.4±
2
.6kgであった。右側第一乳臼歯は処置前13.
9
±
2
.
7
kg,処置後17.
8
±
2
.3kg,左側第一乳臼歯は処置前14.
2
±3.1kg,処置後17.3±
2
.
7
kgであった。各部位の処置前と処置後の咬合力の平均値の差の検定では,いずれの部位においても有意差が認められ,処置後の方が明らかに高い値を示した(p<0.01)。
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Stimulative Effects of (
22E
,24R)-Ergosta-
7
,
22
-diene-3β,
5α
,6β-triol from Fruiting Bodies of Tricholoma auratum, on a Mouse Osteoblastic Cell Line, MC3T3-
E
1

Keishi Hata, Fuyuki Sugawara, Naganori Ohisa, Saori Takahashi, Kazuyuki Hori

Biological and Pharmaceutical Bulletin
2002年 25 巻 8 号 1040-1044
発行日: 2002年
公開日: 2002/08/01

DOI https://doi.org/10.1248/bpb.25.1040

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We screened the differentiation-inducing activities of 39 mushroom extracts from Akita prefecture, Japan, on the mouse osteoblastic cell line, MC3T3-
E
1. Sixteen phosphate buffered saline (PBS),
8
boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC3T3-
E
1 cell differentiation. The enzyme activities were markedly induced by extracts of Tricholoma auratum, and we isolated the active compound from methanol extracts of this mushroom. Physical data for the isolated active compound were identical to those for (
22E
,24R)-ergosta-
7
,
22
-diene-3β,
5α
,6β-triol (1). 1 induced ALP activities of MC3T3-
E
1 cells and promoted cell proliferation. To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC3T3-
E
1 cells by 1, ergosterol (
2
), ergocalciferol (3), cholesta-3β,
5α
,6β-triol (4),
7
-dehydrocholesterol (
5
) and cholecalciferol (6) were tested. The enzyme activities of MC3T3-
E
1 cells were increased 3.0-fold by 10 μM 1 and
2
.4-fold by 10 μM 4. However,
2
, 3,
5
and 6 did not induce MC3T3-
E
1 cell ALP activity at 0.1—10 μM. These results suggested that the OH groups at C-
5
and/or C-6 of 1 and 4 played an important role in their differentiation-inducing activities on MC3T3-
E
1 cells. Furthermore, 1 suppressed induction of MC3T3-
E
1 cell apoptosis by serum starvation.
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英国における過去半世紀 (1922～1972) 間の冶金用コークスの研究

George W. Lee

燃料協会誌
1973年 52 巻 3 号 171-177
発行日: 1973/03/20
公開日: 2010/06/28

DOI https://doi.org/10.3775/jie.52.171

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牛におけるProstaglandin
F_2αcv
とEstradiol bonzoateの同時筋肉注射による発情同期化

金田義宏, 加茂前秀夫, 百目鬼郁男, 尹漢武, 中原達夫

家畜繁殖学雑誌
1978年 24 巻 4 号 169-173
発行日: 1978/12/05
公開日: 2008/05/15

DOI https://doi.org/10.1262/jrd1977.24.169

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放牧牛において,prostaglandin
F_2α
(
PGF_2α
)とestradiol benzoate(
E₂B
)の同時筋肉注射による発情同期化効果及び同期化された発情期における受胎性にっいて検討し,次の成績を得た。
1.放牧牛31頭(ホルスタイン種未経産牛)において,黄体期に
PGF_2α15mg
を筋肉注射(A群15頭)あるいはこれと同時に
E₂BO
.
5
mgを筋肉注射(B群16頭)した結果,処置後31~
96
時間に発情が発現したものはA群では13頭(86.
7
%),B群では15頭(93.
8
%)であり,両群の間には大差がなかった。しかし,発情はA群では処置後37~84時間に13頭 (86.
7
%),B群では31~60時間に14頭(87.
5
%)に集中して発現し,
E₂B
の併用によって発情発現までの時間は短縮した。
2
.排卵は,A群では処置後73~120時間に13頭(86.
7
%),B群では61~
96
時間に14頭(87.
5
%)に起こり,
E₂B
の併用によって排卵の時期は処置後早期に,かつ短い時間帯に集中した。
3.同期化された発情期に授精したA群の13頭中
7
頭(53.
9
%),B群の16頭中
9
頭(56.3%)がそれぞれ受胎し,受胎率において両群の間に差異はなかった。
4.以上の成績から,
PGF_2α
と
E₂B
を同時に併用筋肉注射することは,発情及び排卵の同期化に効果的であることを認めたが,この処置によって同期化された発情期の受胎性については,さらに多数例について検討する必要がある。
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71(P
2
-1) 軟サンゴ、オオウミキノコからの新センブラン型ジテルペン類の構造と分子内閉環反応(ポスター発表の部)

小林優, 家坂貴子, 中野江身子, 平山耕一郎

天然有機化合物討論会講演要旨集
1989年 31 巻 71/P2-1
発行日: 1989/09/17
公開日: 2017/08/18

DOI https://doi.org/10.24496/tennenyuki.31.0_540

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Six new cembranoids sarcophytol P (3), R (4), S (
5
), K (
8
),
F
(11), and T (13) were isolated from the soft coral Sarcophyton glaucum. Sarcophytol P (3) was shown to be the 20-hydroxy derivative of the major component sarcophytol A (1), and afforded the cyclization product 6 in CHCl_3 at room temperature, in a same way as in 1. Sarcophytols R (4) and S (
5
) were correlated to 1, by conversion of its
7
R,
8
R and
7
S,
8
S epoxide derivatives. Sarcophytol K(
8
) was a 13, 14-dihydroxycembranoid having a 1
E
,3Z-diene moiety. The absolute configuration of
8
and its 1Z,3
E
- and 1Z,3Z-isomers sarcophytol B (
2
) and J (10) were determined by circular dichroism study of their bis-p-dimethylaminobenzoate derivatives. Sarcophytols
F
(11) and T (13) were 1
E
- and 1
E
,3Z-isomers of 1. Compound 11 showed characteristic broadening of the ^1H-NMR chemical shifts, due to the restricted conformational interconversion. Using the three cembranoids sarcophytols
F
(11, 1
E
,3
E
), N (15, 1Z,3Z) and T (13,1
E
,3Z), spontaneous autoxidation-cyclization, in CHCl_3,was examined, in order to compare the stereochemical course of the reaction with that of 1 (1Z,3
E
), which affords trans-fused bicyclo[
9
.3.0]tetradecene systems. The 1
E
,3Z-isomer 13 gave the same cyclization product 18, as in the reaction of 1, even though it is isomeric at C-1,3. The 1Z,3Z isomer 15 gave 19, in consequence of the reversed geometry at C-3 of 15. The 1
E
,3
E
-isomer (11) gave the bicyclic product
22
, having an antipodal fusion as compared with 19. This was confirmed by PCC oxidation of 19 and
22
, giving enantiomeric ketones 23 and 24 respectively. The 1(14)-epoxide 26 was shown to be the immediate precursor of
22
, and acounted for the inversion of the geometry at C-1 of the cyclization product. Compound 26 is isomeric with the epoxide 17 derived from 1. The epoxide 17 is the postulated precursor in the conversion of 13 to 18. It is noteworthy that the mode of antipodal fusion of the cyclopentane rings, in 18 and
22
, was controlled by the chirality of the epoxy rings. The C-14 hydroxyl group participates in the transannular cyclization, but was found not to be the requisite functional group for the reaction. Similar treatment of cembrene C (30), the parent hydrocarbon of 1, also reacted in CHCl_3 giving the bicyclic product 32.
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