CTAの行政上の取り扱い、歴史、投資戦略等をまず簡単に説明する。CTAとは金融先物、オプション、スワップを対象とした取り引きに関する投資のアドバイスやサービスを個人、ファンドに提供する個人、または組織に対する金融行政上の用語で、正式名はCommodity trading advisorである。CTAという用語は投資信託、ETFを含むヘッジファンド、プライベートファンドへの投資アドバイスにも適応される。CTAs は米国連邦政府による規制対象であり Commodity Futures Trading Commission (CFTC) への登録と National Futures Association (NFA) のメンバーになることが義務付けられている。また、CTAはヘッジファンドの投資スタイルのひとつ (Global Macro) でもある。

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DiGeorge syndrome (DGA), velocardiofacial syndrome (VCFS), and conotruncal anomaly face syndrome (CTAF) are frequently associated with q11. deletion syndrome. We report two cases of q11. deletion syndrome. Two patients had cleft palate, and facial dysmorphism. Fluorescence in situ hybridization (FISH) was used to show deletion of chromosome q11.. Palatoplasty was performed at about two years of age with the patients under general anesthesia. The postoperative course was uneventful in both patients.

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帯状疱疹に対するRo-8181の有効性, 安全性および有用性を検討するため, ヒト血清アルブミンを対照薬として, 二重盲検比較試験を行つた。皮膚症状の観察項目別の改善率では, 水疱·膿疱において投与開始後5日目でRo-8181群70%, placebo群50%で, 両群間に差(p<0.05)が認められた。皮膚症状改善度の推移を著明改善以上の症例についてみると, 投与開始後4日目の著明改善率はRo-8181群8%, placebo群0%であり, Fisherの直接計算法で両群間に差(p<0.05)が認められた。また, 投与開始後5日目の著明改善率はRo-8181群15%, placebo群3%であり, 検定で両群間に差(p<0.05)が認められた。主治医による有効性の判定ではU検定でRo-8181群が優れている傾向が認められた。主治医による安全性の判定では副作用発現率がRo-8181群83%, placebo群14%であり, U検定で両群間に差(p<0.001)が認められた。主治医による有用性の判定ではU検定で両群間に差は認められなかつた。以上の結果より, 帯状疱疹に対し, Ro-8181は皮疹のうち水疱·膿疱に対して有効であり, 主治医判定でも有効性が認められたが, 安全性については本薬剤の耐薬性が示されたものの副作用の発現率が高かつたため, 有用性は高くないと考えられた。

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The Japan Society for Occupational Health (JSOH) recommends the Occupational Exposure Limits (OELs) as reference values for preventing adverse health effects on workers caused by occupational exposure to chemical substances, continuous or intermittent noise, impulsive or impact noise, heat stress, cold stress, whole-body vibration, hand-arm vibration and time-varying electric, magnetic and electromagnetic fields and ultraviolet and ionizing radiation.

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Intracerebral injection of vegetative myxamoebae of strains of Polysphondylium pallidum caused 80 to 100% mortality in mice, whereas a 30 to 50% mortality occurred with strains of Dictyostelium giganteum and D. mucoroides. Death is attributable to an unidentified toxic factor. Histopathologically a giant cell formation was seen in the spleen of mice. This cell was different from Langerhan's or foreign body giant cell. Rats injected intracerebrally behaved similarly. Intranasal instillation of myxamoebae in guinea pigs caused transient pneumonia. Myxamoebae do not multiply in the brain tissues of mice or rats, or in the lungs of guinea pigs.
Intranasal instillation of vegetative myxamoebae is less pathogenic than free living amoebae like Hartmanella culbertsoni, H. rhysodes, Naegleria sp. (Culbertson strain HB-1), or Naegleria aerobia.

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We report three cases of q11. deletion syndrome (CATCH; cardiac defects, abnormal faces, thymic hypoplasia, cleft palate and hypocalcemia with chromosome q11. deletion) with various complications including hearing loss and nasopharyngeal problems. All three cases we report here had congenital cardiac defects. Two of the three cases had cleft palate, one overt and the other submucoals. Although one of the three cases had a normal hearing level, the other two were almost deaf, one with and the other without inner ear anomalies. The former case was prescribed a hearing aid, and for the latter case, cochlear implantation operation was conducted at the age of three years and seven months. Both of these patients have successfully developed communication skills.
CATCH shows a variety of phenotypes, including hearing loss and nasopharyngeal malformations, either of which may disturb speech ability and thus, furthermore, mental development of the child. However, this condition may be improved by early and adequate intervention. Thus, otolaryngologists should be familiarized with the typical facial abnormality and most frequent manifestations of this syndrome, and be ready to treat patients with q11 deletion, providing them with intensive and individualized prescription at their early stages.

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The nd Annual Meeting of Japan Society for Science Education (JSSE) was held on July 29-31, 1998 at Tokyo Gakugei University in western suburb of Tokyo with about 290 registrants under the main theme of "Towards Implementation of Science Curriculum for Construction of Creation and Symbiosis." Number of papers over 210 were presented in both main sessions and general presentations. There were two symposiums, one lecture, one forum, one international forum, one workshop, three sessions of themes set by the steering committee and ten sessions of themes set independently by members of JSSE in main sessions. Also, there were many other general presentations. Many papers were presented coping with the main theme. They were a lecture related to learning and creativity based on advance of brain, and many presentations related to symbiosis such as relation between in-door and out-door school activities, school based research activities such as curriculum development, and way of finding new methodology of research on classroom, consistency of curriculum through elementary to high school, pre-service teacher education, and so on. Contents of claims and discussions in every presentation in main sessions are summarized in this paper.

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A financial market is a diversified dynamical system with many constraints, and price movements are modeled in terms of the micro properties of each transactions and the macro properties of dynamical systems. These two properties must be bridged by the multiplicity. The model forcuses on the size of tick and the number of transactions with the price movement compared with the previous transctions and explains stochastic nature of short-term volatilities and persistently stable long-term volatilities as a results of unique behaviour of heterogeneous market participants.

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The phase decomposition of the β′ phase in the Zn- mass%Al and Zn- mass%Al- mass%Cu at room temperature was followed by means of the X-ray diffraction (XRD), transmission electron microscopy (TEM) and Vickers hardness (VH) measurements. Alloys were homogenized at 623 K for 432 ks and then quenched at 275 K. Immediately, they were characterized by XRD and simultaneously other samples were analyzed by hardness Vickers measurements. The XRD results showed that the β′ phase is unstable at room temperature and its decomposition finished after 1.8 and 18 ks by the following reaction, β′→α+η, for the Zn- mass%Al and Zn- mass%Al- mass%Cu alloys, respectively. The TEM analysis was carried out in the Zn- mass%Al- mass%Cu alloy, which showed a slower kinetics than the Zn- mass%Al alloy. The TEM results showed in situ that the β′ phase is in coexistence with the ε phase and its decomposition occurs by the formation of colonies composed of nanometric grains of the α and η phases. Such colonies extend to cover completely all the surface of the alloy, followed by the coarsening of grains to the micrometer scale. The Vickers hardness results showed an increase in hardness up to a maximum of 108 and 148 VH, followed by a decreasing in hardness of 50 and 80 VH, for the natural aging of the Zn- mass%Al and Zn- mass%Al- mass%Cu alloys, respectively. These results can be attributed to the presence of the nanometric and micrometric grains, respectively.

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The linkage search for susceptibility loci using SNP markers in hereditary hearing loss has proven challenging due to genetic heterogeneity. We conducted a genome-wide linkage analysis using high-density SNP markers in two Korean families (families coded SD-J and SR-167) with autosomal dominant non-syndromic hearing loss (ADNSHL). Evidence was found of linkage at 8q24.13~q24.3 and 10p11.21~q. (LOD 3.01) in the SD-J family. In the case of family SR-167, which had the most affected members, the parametric LOD score was low owing to the lack of power for linkage analysis. However, using non-parametric linkage analysis, it was possible to obtain significant evidence for linkage at 10q.1~q23.31 (LOD 1.79; NPL 6.47, P < 0.00001). There is an overlapping region with a significant LOD score between the SD-J and SR-167 families, which encompasses 4 cM at 10q.1~.. Interestingly, the characteristics of hearing loss in both families were similar, and the haplotype within overlapping region was shared in the affected individuals of the two families. We performed direct sequencing of the candidate genes that are thought to be causing the condition, but no disease-causing mutations were identified.

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To elucidate the temperature effects on the crystal growth of C₆₀ molecules at a molecular level, we performed molecular dynamics calculations for the crystal growth to the substrate and nucleation in gas-phase. We found two crystallization processes: (i) a direct crystal growth of C₆₀ molecules onto the crystal substrate, and (ii) a nucleation in the gas-phase under low temperature conditions.

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使用済みハロカーボンの無害化処理のため，および殺菌灯を用いて，光触媒分解反応実験を行った．化学物質の置換基の違いによる分解速度の解析のため，対象とする化学物質は，構造が同じで置換基が異なるHCFC-，四塩化炭素，メタンを用いた．それぞれの物質の分解反応速度解析をおこなった．主な結果として，分解率はHCFC-が最も大きく，次いでメタン，CCl₄の順であった．光触媒反応の反応次数は本実験条件範囲では一次であった．総括的反応速度定数から求めた活性化エネルギーはそれぞれHCFC-が13.7 kJ·mol⁻¹，CCl₄が66.1 kJ·mol⁻¹，メタンが16.6 kJ·mol⁻¹であった．

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本稿では，有機色材の発色性にかかわる量子化学的物性値を量子化学計算により精度良く予測する方法について示した。最もよく使われる密度汎関数法の特徴を，ほかの量子化学計算手法と比較した。精度が高い量子化学計算の計算条件（汎関数，基底，溶媒効果）を複数の色材の種類や量子化学的物性値に関して示した。ベンチマークを参照し，精度が高い計算条件を選択する方法についても示した。量子化学計算ソフトウエアを導入する際に考慮すべき注意点についても述べた。

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