Whey Protein-hydrolyzed Peptides Diminish Hepatic Lipid Levels in Rats Consuming High-sucrose Diets

Daigo Yokoyama; Hiroyuki Sakakibara; Hajime Fukuno; Keisuke Kimura; Amane Hori; Takayuki Nara; Ken Kato; Masanobu Sakono

doi:10.3136/fstr.22.631

Original papers

Whey Protein-hydrolyzed Peptides Diminish Hepatic Lipid Levels in Rats Consuming High-sucrose Diets

Daigo Yokoyama, Hiroyuki Sakakibara, Hajime Fukuno, Keisuke Kimura, Amane Hori, Takayuki Nara, Ken Kato, Masanobu Sakono

Author information

Daigo Yokoyama
Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki
Hiroyuki Sakakibara
Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki
Faculty of Agriculture, University of Miyazaki
Hajime Fukuno
Faculty of Agriculture, University of Miyazaki
Keisuke Kimura
Faculty of Agriculture, University of Miyazaki
Amane Hori
Faculty of Agriculture, University of Miyazaki
Takayuki Nara
Megmilk Snow Brand Co., Ltd., Milk Science Institute
Ken Kato
Megmilk Snow Brand Co., Ltd., Milk Science Institute
Masanobu Sakono Corresponding author
Interdisciplinary Graduate School of Agriculture and Engineering, University of Miyazaki
Faculty of Agriculture, University of Miyazaki

Keywords: cholesterol, dyslipidemia, fatty acid synthase, triglyceride, whey protein-hydrolyzed peptides

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2016 Volume 22 Issue 5 Pages 631-638

DOI https://doi.org/10.3136/fstr.22.631

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Abstract

Whey protein consumption is reported to reduce serum lipids, however the responses to derived peptides have not yet been fully characterized. In this study, we evaluated the effects of whey protein-hydrolyzed peptides (WPP) on serum and hepatic lipid levels, as well as hepatic lipogenic gene expression in SD rats consuming a high-sucrose AIN-76 based diet. After a 14-day ad libitum consumption of diet containing WPP, serum and hepatic triglycerides, and total cholesterol levels were significantly decreased when compared with the control group. A similar trend was observed in the time-restricted feeding groups, in which food was provided for 2 h at the beginning and the end of the dark period cycle during the 14-day treatment period. Additionally, hepatic gene expression linked to triglyceride and cholesterol biosynthesis, and their enzymatic activities were downregulated in the WPP group. In conclusion, daily consumption of WPP appears to decrease lipid levels in the blood and liver, and potentially protect against dyslipidemia.

Corresponding author

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