抄録
Immunohistochemical expression of interleukin 2 receptor (IL2R) is examined by an APAAP method in the peripheral blood mononuclear cells (PBMC) in asymptomatic HBsAg carriers (AsC) and in normal individuals. It is found that the percentage of IL2R-positive cells is significantly lower in PBMC induced by HBsAg or ConA in AsC, but not so by PHA, than that in normal individuals (P<0.01). Moreover, it is found that IL2R-positive cell is surrounded by many IL2R-negative mononuclear cells following induction by HBsAg. This phenomenon is temporarily termed IL2R-positive cell “rosette”. Typical rosette formation of IL2R-positive cells is not observed in induction by ConA and PHA. Besides, when the percentage of IL2R-positive cell rosette is counted, the results show that the prevalence of rosette formation is much higher in normal individuals than that in AsC (P<0.01). This new phenomenon of immune response to HBsAg may be of important significance in immunoregulation. The results suggest that the abnormal IL-2R expression and immunoregulation of IL2R-positive cell may be an important mechanism of poor immune response to hepatitis B virus (HBV) in AsC.
