IN VITRO SUSCEPTIBILITY OF PSEUDOMONAS MALTOPHILIA TO ANTIMICROBIAL AGENTS

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We examined 91 clinically significant isolates of P. maltophilia for susceptibilities to 27 antimicrobial agents currently available; 6 penicillins, 8 cephem antiobiotics 7 aminoglycosides, 3 tetracyclines, CP, NA and PPA. MINO and DOXY were the most effective agents; almost all of the isolates were inhibited by 6.25 and all of isolates by 12.5μg or less per ml, respectively. A large number of the isolates tested were highly resistant to β-lactam antibiotics except to LMOX. LMOX was fairly active, and 74% of the isolates were inhibited by 25μg or less per ml. Aminoglycosides tested had a wide distribution of MIC that 83-93% of the isolates were not inhibited at 6.25μg or less per ml. TC, CP, NA and PPA were less active. Yearly changes of the activities of the antimicrobial agents tested against P. maltophilia were not significant with the exception of TC to which a 3-fold increase of resistance have been shown.