Identification of (+)-Phyllocladene, (−)-Sandaracopimaradiene, and (+)-Kaurene as New Fungal Metabolites from Fusicoccin-producing Phomopsis amygdali F6

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A chemical analysis of the diterpene hydrocarbons produced by fusicoccin-producing fungus Phomopsis amygdali F6 identified five phyllocladene-related tri- and tetracyclic diterpene hydrocarbons. The presence of (+)-phyllocladene, (−)-sandaracopimaradiene, (+)-isopimara-8,15-diene, and (+)-pimara-8(14),15-diene in the fungus was demonstrated by GC-MS, ¹H-NMR, and [α]_D measurements. (+)-Kaurene was also identified by GC-MS and chiral capillary GC. The possible biosynthetic relationship of these metabolites is discussed.