Inhibitory Effects of Whisky Congeners on Melanogenesis in Mouse B16 Melanoma Cells

Kenji OHGUCHI; Minako KOIKE; Yoshihide SUWA; Seiichi KOSHIMIZU; Yuki MIZUTANI; Yoshinori NOZAWA; Yukihiro AKAO

doi:10.1271/bbb.70734

Food & Nutrition Science Notes

Inhibitory Effects of Whisky Congeners on Melanogenesis in Mouse B16 Melanoma Cells

Kenji OHGUCHI, Minako KOIKE, Yoshihide SUWA, Seiichi KOSHIMIZU, Yuki MIZUTANI, Yoshinori NOZAWA, Yukihiro AKAO

著者情報

キーワード: whisky congeners, melanin, melanogenesis, tyrosinase

ジャーナルフリー

2008 年 72 巻 4 号 p. 1107-1110

DOI https://doi.org/10.1271/bbb.70734

View "Advance Publication" version (April 7, 2008).

詳細

抄録

We examined the effect of whisky congeners, substances other than ethanol in whisky, on melanogenesis in mouse B16 melanoma cells. Treatment with whisky congeners significantly blocked melanogenesis. Our results indicate that the inhibitory effects of whisky congeners on melanogenesis is due to direct inhibition of tyrosinase activity and to suppression of tyrosinase protein levels.

責任著者(Corresponding author)

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