Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
Food & Nutrition Science Notes
Physiological Effects and Tissue Distribution from Large Doses of Tocotrienol in Rats
Akira SHIBATAKiyotaka NAKAGAWAHitoshi SHIRAKAWATeiko KOBAYASHIYuki KAWAKAMIRie TAKASHIMAAi OHASHIShoko SATOYusuke OHSAKIFumiko KIMURAToshiyuki KIMURATsuyoshi TSUDUKIMichio KOMAITeruo MIYAZAWA
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2012 年 76 巻 9 号 p. 1805-1808

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Supplementation to an AIN93G-based diet of tocotrienol (T3) for 13 weeks administered to Fischer 344/slc rats showed a safety profile with no side effects. Dose-dependent T3 levels were detected in many tissues. Under the present experimental conditions, a continuous intake of the T3 concentrate would be safe in the rats as long as the T3 content was less than 0.20% of the dietary intake.
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© 2012 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
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