Antimicrobiological Activity of Lignan: Effect of Benzylic Oxygen and Stereochemistry of 2,3-Dibenzyl-4-butanolide and 3,4-Dibenzyltetrahydrofuran Lignans on Activity

Koichi AKIYAMA; Masafumi MARUYAMA; Satoshi YAMAUCHI; Yuki NAKASHIMA; Tomofumi NAKATO; Ryosuke TAGO; Takuya SUGAHARA; Taro KISHIDA; Yojiro KOBA

doi:10.1271/bbb.70168

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Antimicrobiological Activity of Lignan: Effect of Benzylic Oxygen and Stereochemistry of 2,3-Dibenzyl-4-butanolide and 3,4-Dibenzyltetrahydrofuran Lignans on Activity

Koichi AKIYAMA, Masafumi MARUYAMA, Satoshi YAMAUCHI, Yuki NAKASHIMA, Tomofumi NAKATO, Ryosuke TAGO, Takuya SUGAHARA, Taro KISHIDA, Yojiro KOBA

著者情報

キーワード: antimicrobiological activity, γ-butyrolactone lignan, tetrahydrofuran lignan

ジャーナルフリー早期公開

論文ID: 70168

DOI https://doi.org/10.1271/bbb.70168

この記事には本公開記事があります。

The final version of this article is now available: Vol. 71 (2007) , No. 7 p.1745

詳細

抄録

The effect of oxidation degree at the benzylic position of 2,3-dibenzyl-4-butanolide and 3,4-dibenzyltetrahydrofuran lignans on the antimicrobiological activity was examined. The highest oxidation degree at the benzylic position of 2,3-dibenzyl-4-butanolide gave the greatest activity, and 3,4-dibenzoyltetrahydrofuran showed the highest antifungal activity. The relationship between stereochemistry and activity was also examined. Both enantiomers of cis-matairesinol were synthesized for the first time, one of the cis-matairesinols showing antibacterial activity.

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