抄録
A variety of long-chain fatty acylamino analogs of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP), such as N-(acyl)muramoyl-dipeptides (1) and N-acetyl-6-(acylamino)-6-deoxymuramoyl-dipeptides (2), were synthesized to examine their immunological activities. All the N-(acyl)muramoyl-L-alanyl-D-isoglutamines (1) were active as adjuvant on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-L-tyrosine in guinea pigs. N-(3-Hydroxy-2-tetradecyloctadecanoylamino)muramoyl-L-alanyl-D-isoglutamine (1d) and N-acetyl-6-deoxy-6-(3-hydroxy-2-docosylhexacosanoylamino)murarnoyl-L-alanyl-, -L-valyl-, and -L-seryl-D-isoglutamines (2) showed antitumor activity by suppressing tumor (Meth-A fibrosarcoma) growth in syngeneic BALB/c mice.
