Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Antiinflammatory Activity of Astilbic Acid from Astilbe chinensis
Tae Chul MoonChang Xiu LinJoo Sang LeeDong Seon KimKiHwan BaeKun Ho SonHyun Pyo KimSam Sik KangJong Keun SonHyeun Wook Chang
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2005 年 28 巻 1 号 p. 24-26


This study examined the effect of astilbic acid (3β,6β-dihydroxyolean-12-en-27-oic acid), which is a herbal medicine isolated from Astilbe chinensis. Astilbic acid inhibited 5-lipoxygenase (5-LOX)-dependent leukotriene C4 (LTC4) generation in bone marrow-derived mast cells in a concentration-dependent manner with an IC50 value of 2.1 μM. In addition, astilbic acid was tested in a rat passive cutaneous anaphylaxis (PCA) reaction assay by administering 10 to 50 mg/kg i.p. Astilbic acid dose dependently inhibited the PCA reaction, which was activated by anti-dinitrophenyl (DNP) IgE. Furthermore, this compound inhibited mouse acetic acid-induced writhing (47—62% inhibition at 0.4—50 mg/kg) after being administered orally, while aspirin (200 mg/kg) showed 62% inhibition. These results suggest that astilbic acid may be beneficial in regulating various inflammatory processes.

© 2005 The Pharmaceutical Society of Japan
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