Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
A Novel Drug Delivery System of Oral Curcumin Markedly Improves Efficacy of Treatment for Heart Failure after Myocardial Infarction in Rats
Yoichi SunagawaHiromichi WadaHidetoshi SuzukiHiroki SasakiAtsushi ImaizumiHiroyuki FukudaTadashi HashimotoYasufumi KatanasakaAkira ShimatsuTakeshi KimuraHideaki KakeyaMasatoshi FujitaKoji HasegawaTatsuya Morimoto
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2012 年 35 巻 2 号 p. 139-144

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Curcumin is an inhibitor of p300 histone acetyltransferase activity, which is associated with the deterioration of heart failure. We reported that native curcumin, at a dosage of 50 mg/kg, prevented deterioration of the systolic function in rat models of heart failure. To achieve more efficient oral pharmacological therapy against heart failure by curcumin, we have developed a novel drug delivery system (DDS) which markedly increases plasma curcumin levels. At the dosage of 0.5 mg/kg, DDS curcumin but not native curcumin restored left ventricular fractional shortening in post-myocardial infarction rats. Thus, our DDS strategy will be applicable to the clinical setting in humans.

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© 2012 The Pharmaceutical Society of Japan
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