Intracoronary Injection of Granulocyte Colony-Stimulating Factor Ameliorates the Progression of Left Ventricular Remodeling After Myocardial Ischemia/Reperfusion in Rabbits

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Background Although granulocyte colony-stimulating factor (G-CSF) is known to prevent left ventricular (LV) remodeling after acute myocardial infarction (AMI), the best method of administration is unknown. Methods and Results A rabbit ischemia/reperfusion model was created and G-CSF was administered into the coronary artery immediately after reperfusion. The LV size and contraction were determined by echocardiography, and the extent of infarcted myocardium was measured by Masson-Trichrome staining. The benefits of intracoronary injection of G-CSF on LV remodeling were similar to subcutaneous injection. Conclusions Direct intracoronary G-CSF injection may become a new therapy for AMI with lower adverse effects. (Circ J 2006; 70: 942 - 944)