Synthesis of Actinomycin Analogs. I.

Abstract

In the course of investigation on the synthesis of analog of actinomycin, L-threonine, O-benzyl-L-serine, and methyl esters of glycine, DL-alanine, L-threonine, DL-threonine, and O-benzyl-L-serine were acylated with 2-nitro-3-methoxybenzoyl chloride or azide. Some of these products were catalytically hydrogenated to 2-amino-3-methoxybenzoyl compounds. N-(2-Nitro-3-methoxybenzoyl)-glycyl-DL-valine methyl ester was synthesized from N-(2-nitro-3-methoxybenzoyl)-glycyl azide.