Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Efficient Synthesis of Isocarbacyclins
Mikiko SODEOKA, Yuji OGAWA, Toshiaki MASE, Masakatsu SHIBASAKI
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Keywords: isocarbacyclin, thermal ene reaction, intramolecular aldol condensation, regioselective hydrogenation, bicyclo[3.3.0]octene
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1989 Volume 37 Issue 3 Pages 586-598

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Abstract
An efficient and useful synthesis of isocarbacyclins, potent carbon analogs of Prostacyclin(PGI2), has been accomplished.Three synthetic routes to isocarbacyclins using intramolecular thermal ene reaction or intramolecular aldol condensation as a key step are described.
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© The Pharmaceutical Society of Japan
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