抄録
The Schiff bases, N-(S-guaiazulen-3-ylmethylene)cyclohexylamine (II), N-(S-guaiazulen-3-ylmethylene)benzylamine (III), and N-(S-guaiazulen-3-ylmethylene)-1, 1-dimethyl-2-hydroxyethylamine (IV) were prepared in excellent yields by condensation of S-guaiazulene-3-carboxaldehyde (I) with corresponding primary amines. These bases were easily converted into secondary amino derivatives of S-guaiazulene, i.e. 3-cyclohexylaminomethyl-S-guaiazulene hydrochloride (VIII), 3-benzylaminomethyl-S-guaiazulene hydrochloride (IX), and 3-(1, 1-dimethyl-2-hydroxyethylaminomethyl)-S-guaiazulene hydrochloride (X), by catalytic hydrogenation and salt formation with hydrochloric acid
