Food Science and Technology Research
Online ISSN : 1881-3984
Print ISSN : 1344-6606
ISSN-L : 1344-6606
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α-Glucosidase Inhibitory Profile of Nigerian Medicinal Plants in Immobilized Assay System
Isiaka Ajani OGUNWANDEToshiro MATSUITomoko FUJISEKiyoshi MATSUMOTO
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2007 Volume 13 Issue 2 Pages 169-172

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Abstract

Four Nigerian medicinal plants used for the treatment of various ailments in traditional ethnomedicine were evaluated for their anti-diabetic potential. The plants Irvingia gabonensis (O'Rorke) Bail, Eucalyptus torreliana F.v. Muell, Securidata longependuculata Fers and Murraya paniculata (L.) Jack were used in the study. Only the aqueous extract of I. gabonensis exhibited a potent maltase-inhibitory activity with an IC50 of 0.10mg/mL, as well as a sucrase-inhibitory activity (IC50 of 0.11mg/mL), whereas α-amylase inhibitory activity was quite poor (IC50 of 0.53mg/mL). A significant lowering of the blood glycemic response to maltose ingestion in 8-week old Sprague-Dawley rats was observed at a dose of 300mg/kg, in response to significant reduction in postprandial insulin response level.

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© 2007 by Japanese Society for Food Science and Technology
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