α-Lipoic Acid Inhibits Melanogenesis in Three-dimensional Human Skin Model

Tomonori UNNO; Fumihiro ITO; Yuko M. SAGESAKA

doi:10.3136/fstr.15.537

Food Science and Technology Research

Online ISSN : 1881-3984
Print ISSN : 1344-6606
ISSN-L : 1344-6606

Notes

α-Lipoic Acid Inhibits Melanogenesis in Three-dimensional Human Skin Model

Tomonori UNNO, Fumihiro ITO, Yuko M. SAGESAKA

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Keywords: α-lipoic acid, melanin, tyrosinase, three-dimensional human skin model

JOURNAL FREE ACCESS

2009 Volume 15 Issue 5 Pages 537-540

DOI https://doi.org/10.3136/fstr.15.537

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Abstract

The overproduction of pigmentary melanin in the skin causes an undesirable cosmetic appearance. The present study was undertaken to evaluate the inhibitory effect of α-lipoic acid (LA) on melanogenesis using a three-dimensional human skin model with ultraviolet (UV) irradiation. It is evident that melanin biosynthesis in human skin cells was decreased by the treatment with LA under the concentration range from 0.01 to 0.1% (w/v) in a concentration-dependent fashion, reflecting no effect on cell viability.

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