2012 Volume 18 Issue 6 Pages 919-922
The cellular effects of 1-[5-(Hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic acid (Flazin) were examined. The Flazin content of Koikuchi and Tamari soy sauce was 65.1 μg/mL and 232.0 μg/mL, respectively. Flazin strongly inhibited the proliferation of HL-60 cells (IC50 = 20.0 μg/mL; 64.9 μM), although it only weakly inhibited HeLa and VSMC cells. DNA fragmentation results from a TUNEL assay suggest that apoptotic activity induced by Flazin is involved in the inhibition of HL-60 cell proliferation.