Cellular Effects Of Tamari Soy Sauce-derived 1-[5-(Hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic Acid (Flazin)

Masahiro NISHIO; Kanako YUASA; Koji OKIMURA; Mika OGAMO; Kunio IMAI; Hirotaka KATSUZAKI; Masayoshi MATSUNAGA; Hayato UMEKAWA

doi:10.3136/fstr.18.919

Note

Cellular Effects Of Tamari Soy Sauce-derived 1-[5-(Hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic Acid (Flazin)

Masahiro NISHIO, Kanako YUASA, Koji OKIMURA, Mika OGAMO, Kunio IMAI, Hirotaka KATSUZAKI, Masayoshi MATSUNAGA, Hayato UMEKAWA

Author information

Masahiro NISHIO
Department of Sustainable Resource Science, Graduate School of Bioresources, Mie University
Kanako YUASA
Department of Sustainable Resource Science, Graduate School of Bioresources, Mie University
Koji OKIMURA
Department of Sustainable Resource Science, Graduate School of Bioresources, Mie University
Mika OGAMO
Department of Sustainable Resource Science, Graduate School of Bioresources, Mie University
Kunio IMAI
Department of Life Science, Graduate School of Bioresources, Mie University
Hirotaka KATSUZAKI
Department of Life Science, Graduate School of Bioresources, Mie University
Masayoshi MATSUNAGA
Sanjirushi Corp.
Hayato UMEKAWA
Department of Sustainable Resource Science, Graduate School of Bioresources, Mie University

Keywords: Flazin, soy sauce, HL-60, DNA fragmentation, TUNEL

JOURNAL OPEN ACCESS

2012 Volume 18 Issue 6 Pages 919-922

DOI https://doi.org/10.3136/fstr.18.919

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Abstract

The cellular effects of 1-[5-(Hydroxymethyl)furan-2-yl]-9H-pyrido[3,4-b]indole-3-carboxylic acid (Flazin) were examined. The Flazin content of Koikuchi and Tamari soy sauce was 65.1 μg/mL and 232.0 μg/mL, respectively. Flazin strongly inhibited the proliferation of HL-60 cells (IC₅₀ = 20.0 μg/mL; 64.9 μM), although it only weakly inhibited HeLa and VSMC cells. DNA fragmentation results from a TUNEL assay suggest that apoptotic activity induced by Flazin is involved in the inhibition of HL-60 cell proliferation.

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