Abstract
Uridine, a pyrimidine nucleoside present in many foods, is a modulator in the central nervous system. Uridine behaves as an anticonvulsant in a number of seizure models and also promotes sleep. In this study, we exposed mice to social isolation stress for 4 weeks and then investigated the effects of uridine on the changes induced by stress. Social isolation stress increased locomotor activity in an open field. This increase in locomotor activity was suppressed by uridine. Moreover, uridine prevented social isolation stress-induced aggressive behavior. To investigate how uridine administration modifies neurotransmitters, we estimated the concentration and release of neurotransmitters in the prefrontal cortex. Uridine modulated serotonin release. Our results suggest that uridine attenuates the behavioral changes due to social isolation stress in mice.
