Food Science and Technology Research
Online ISSN : 1881-3984
Print ISSN : 1344-6606
ISSN-L : 1344-6606
Original papers
Hepatoprotective Effects of Triterpenoid Isolated from Schizandra chinensis against Acute Alcohol-Induced Liver Injury in Mice
Lijie ZHUBin LIXiuying LIUXianjun MENG
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2013 Volume 19 Issue 6 Pages 1003-1009

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Abstract

Schizandra chinensis (Turcz.) Baill (SC) is useful for the regulation of various pathological conditions in Northeast Asia and is known to possess antioxidant activity. Here, triterpenoid of SC (TSC) was isolated from ethanol-water extracts of SC by using an octadecylsilyl column and shown to be one of the major active constituents of SC. The hepatoprotective effects of TSC in a mouse model of acute alcohol-induced liver injury (AALI) were evaluated based on serum biochemical indicators and antioxidative capacity. Severe liver damage caused by alcohol intake with increasing activation of hepatic markers was decreased in the group of mice fed TSC, and the results were confirmed through hematoxylin and eosin staining. Serum biochemical indicators and antioxidative capacity were decreased by alcohol but recovered by TSC. Furthermore, TSC increased the activity of antioxidant enzymes and reduced inflammatory reactions. The experimental results indicate that TSC has preventive and therapeutic effects against AALI.

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© 2013 by Japanese Society for Food Science and Technology
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