Dietary Proteins during Late Pregnancy Affect Hyaluronan Levels, and Modulate Hyaluronan synthase 2 and KIAA1199 mRNA Expression in the Skin of Newborn Mice

Abstract

In this study, we investigated the effects of dietary protein types during late pregnancy on hyaluronan metabolism in the skin of newborn mice. Levels of hyaluronan and hyaluronan synthase (Has)2 mRNA expression increased in the skin of newborn mice from dams fed the gluten diet during pregnancy (Gluten group) when compared with those of newborn mice from dams fed the soy protein diet during late pregnancy (Soy group). In contrast, skin mRNA expression of KIAA1199, which plays a primary role in hyaluronan degradation in the dermis, decreased in the Gluten group. These results show that a maternal low-quality protein diet increases hyaluronan levels, modulates Has2 and KIAA1199 mRNA expression in the skin of newborn mice.