Food Science and Technology Research
Online ISSN : 1881-3984
Print ISSN : 1344-6606
ISSN-L : 1344-6606
Original papers
High-dose D-glucosamine Consumption Increases Serum and Cecum Levels of Ammonia and Ethanol and Causes Bacterial Overgrowth in Rats
Dwi Eva NirmagustinaAbdelkrim KhedaraDjamila BenouchenneKarima BoubekriYongshou YangSofya SuidasariThanutchaporn KumrungseeNorihisa Kato
Author information
JOURNALS RESTRICTED ACCESS FULL-TEXT HTML

2019 Volume 25 Issue 1 Pages 107-113

Details
Abstract

D-Glucosamine (GlcN) has been widely consumed as a dietary supplement because of its health benefits. However, limited information exists on the adverse effects of high-dose GlcN treatment. In this study, we investigated the effect of dietary 4 % GlcN hydrochloride on serum and cecum parameters in rats. Growth and food intake were unaffected, but serum levels of ammonia and ethanol significantly increased by GlcN (+21 % and +12 %, respectively). No changes in serum parameters, including AST, ALT, LDH, γ-GTP (indices of liver damage), and urea, were found. The GlcN intake significantly increased the weights of cecal contents (+115 %). Furthermore, supplemental GlcN significantly elevated the levels of ammonia and ethanol (+27 % and +93 %, respectively) and the number of total bacteria (+79 %), when expressed per gram of cecal contents. Our results suggest that high-dose GlcN causes adverse effects by increasing ammonia and ethanol levels and by bacterial overgrowth.

Information related to the author
© 2019 by Japanese Society for Food Science and Technology
Previous article Next article
feedback
Top