In this study, the preventive effects of Lactobacillus plantarum CQPC07 (LP) on dextran sodium sulfate (DSS)-induced male C57BL/6J mice colitis were investigated. The results showed that LP can increase the colon length and decrease the ratio of colon weight/colon length in DSS-induced colitis mice. Analyses of the sera of mice showed that LP can reduce the level of serum endothelin (ET), substance P (SP), and interleukin-10 (IL-10), enhance the activity of somatostatin (SS) and vasoactive intestinal peptide (VIP), and increase the levels of IL-2. Biochemical analyses of colonic tissues from mice showed that LP can increase the levels of glutathione (GSH), superoxide dismutase (SOD), and decrease the level of myeloperoxidase (MPO), malondialdehyde (MDA). A pathological tissue evaluation showed that LP can inhibit colon tissue damage in DSS-treated mice. Furthermore, LP can also increase neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), c-Kit, stem cell factor (SCF) mRNA expression and decrease inducible nitric oxide synthase (iNOS), IL-8, and C-X-C motif chemokine receptor 2 (CXCR2) mRNA levels in the colon tissues of colitis mice. Thus, LP has a colitis inhibitory effect, the higher the concentration, the better the effect, and the effect of high concentration of LP is close to the drug of sulfasalazine.
