Inhibition of lipid digestion by β-glucanase-treated Candida utilis

Abstract

β-Glucanase-treated Candida utilis (GT) has the potential to prevent cardiovascular disease by suppressing elevated postprandial serum triglyceride levels. To clarify the mechanism, in this study, we investigated the effects of GT on lipid digestion. To evaluate the inhibitory activity of pancreatic lipase and the binding ability of bile acid, various yeast samples were prepared with or without β-glucanase treatment, by two-step in vitro digestion, and by water-soluble/insoluble fractionation. The insoluble fraction of GT displayed lipase inhibition and bile acid-binding effects after in vitro digestion, and insoluble fibers and resistant proteins or peptides were thought to be the components involved. The soluble fraction of GT showed slight effects.