Angiotensin I-Converting Enzyme Inhibitory Peptides from Pepsin Digest of Maitake (Gnfola frondosa)

Abstract

Three peptides which inhibit angiotensin I-converting enzyme were isolated from maitake (Grifola frondosa) water extract digested by pepsin. Among them, Lys-Tyr-Thr-Phe-Ala-Val-Thr-Thr-Val-Lys-Thr-Trp-Val had the strongest angiotensin I-converting enzyme inhibitory activity with an IC₅₀ value of 2.6 μM, and the others Gly-Pro-Ser-Gly-Pro-Ser-Gly, and Tyr-Pro-Ser also showed inhibitory activity with IC₅₀ values of 2160 and 570 μM, respectively.