Knockdown of deubiquitinating enzyme Usp34 confers resistance to methylmercury in HEK293 cells

抄録

We have previously reported that the ubiquitin–proteasome system, which is a selective proteolytic system, plays an important role in determining sensitivity to methylmercury in various cultured cells. Deubiquitinating enzyme is a negative regulator of protein degradation through the ubiquitin–proteasome system. In the present study, we searched for deubiquitinating enzymes that affect sensitivity to methylmercury by RNA interference, and identified ubiquitin-specific protease 34 (Usp34) as a deubiquitinating enzyme that confers methylmercury resistance to HEK293 cells by suppressing gene expression.