Fundamental Toxicological Sciences
Online ISSN : 2189-115X
ISSN-L : 2189-115X
Toxicomics Report
Knockdown of deubiquitinating enzyme Usp34 confers resistance to methylmercury in HEK293 cells
Jong-Mu KimJin-Yong LeeMin-Seok KimSawako ShindoTakeshi KumagaiAkira NaganumaGi-Wook Hwang
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2021 年 8 巻 5 号 p. 157-160

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We have previously reported that the ubiquitin–proteasome system, which is a selective proteolytic system, plays an important role in determining sensitivity to methylmercury in various cultured cells. Deubiquitinating enzyme is a negative regulator of protein degradation through the ubiquitin–proteasome system. In the present study, we searched for deubiquitinating enzymes that affect sensitivity to methylmercury by RNA interference, and identified ubiquitin-specific protease 34 (Usp34) as a deubiquitinating enzyme that confers methylmercury resistance to HEK293 cells by suppressing gene expression.

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