Journal of Applied Glycoscience
Online ISSN : 1880-7291
Print ISSN : 1344-7882
ISSN-L : 1344-7882
An α2,3-Linked Sialylglycopolymer as a Multivalent Glycoligand Against Avian and Human Influenza Viruses
Tomonari TanakaYiting ZhouChihiro TamotoYuuki KurebayashiTadanobu TakahashiTakashi Suzuki
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JOURNALS FREE ACCESS Advance online publication

Article ID: jag.JAG-2017_003

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Abstract

A glycopolymer bearing α2,3-linked sialyltrisaccharides was synthesized by living radical polymerization using a glycomonomer prepared by a protecting-group-free process, direct azidation of the free sialyllactose, and subsequent azide-alkyne cycloaddition. The prepared glycopolymer with pendant 3´-sialyllactose moieties strongly interacted with both avian and human influenza viruses analyzed by the hemagglutination inhibition assay and the quartz crystal microbalance method.

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© 2017, by The Japanese Society of Applied Glycoscience
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