2004 年 31 巻 4 号 p. 582-585
It is not yet clear whether both high sensitivity C-reactive protein (hs-CRP) and homeostasis model assessment for insulin resistance index (HOMA-IR), reflect the pathology of cardiovascular diseases in the same way. The relation between conventional cardiovascular risk factors accumulation and hs-CRP and HOMA-IR, as well as the correlation between hs-CRP and HOMA-IR was examined in a cross-sectional study with 334 subjects under screening examination.
Risk factors combinations of obesity, hypertension, glucose intolerance, hyperlipidemia, low HDL cholesterol, and smoking were considered with hs-CRP value, and HOMA-IR. Moreover a simple linear regression analysis was performed between hs-CRP and HOMA-IR.
Although HOMA index values increased along the accumulation of risk factors, no such relationship was found with hs-CRP values. Moreover there was no correlation between hs-CRP and HOMA-IR. Therefore this study showed hs-CRP and HOMA-IR to be different factors and independent cardiovascular risk factors.